Promising New Drug Blocks Mutation in Bone Marrow Cancers
12/09/08 Portland, Ore.
Findings may also help patients with rheumatoid arthritis
The oral drug, called CYT387, was tested in mice as well as in human cells. In both cases, it blocked the growth of certain bone marrow cancers called myeloproliferative disorders, also referred to as MPDs.The research will be presented Tuesday, Dec. 9, at 7 a.m. during the 50th annual American Society of Hematology conference in San Francisco.
“The drug was found to be very effective against a specific type of cancer cells, cancer cells which are driven by an enzyme mutation called JAK2-V617F. In the mouse model, the drug blocked JAK2-V617F, normalized blood counts and reduced enlarged spleens back to a normal size. It is a very promising compound,” said Thomas Bumm, M.D., Ph.D., a member of the research team.
The drug works by binding to the V617F mutation in the JAK2 enzyme. Without this drug, the mutated JAK2 enzyme leads to MPDs. The “big three” MPDs include polycythemia vera, essential thrombocythemia and primary myelofibrosis. Until now there have been no FDA-approved targeted treatments for these diseases.
"Based on the efficacy that we demonstrated in the mouse model, there is a good chance that CYT387 will enter clinical trials as early as 2009. Those in greatest need include patients with myelofibrosis, a relentless disease for which there is currently no effective therapy. It is likely that JAK2 inhibitors will change the standard of care for these patients," said Michael Deininger, M.D., Ph.D., principal investigator and Head of the Hematological Malignancies Program Ph.D.He also is an associate professor of medicine (hematology/medical oncology), OHSU School of Medicine anda Scholar of the Leukemia & Lymphoma Society.
Researchers also discovered that CYT387 effectively blocks overproduction of inflammatory cytokines. Abnormal cells carrying the JAK2-V617F mutation produce a large amount of different inflammatory cytokines that help the cancer cells to grow and repress normal cells. In mice, the drug normalized 19 different inflammatory cytokine levels in the blood. The overproduction of cytokines can also be found in inflammatory conditions such as rheumatoid arthritis. This drug’s effect on cytokines could benefit patients with inflammatory diseases, especially rheumatoid arthritis.
The next likely step will be to open clinical trials for people with MPD as soon as 2009 once formal preclinical toxicology studies are completed.
The investigational drug is made by Cytopia Research Pty Ltd, a publicly registered drug company from Australia. Cytopia sponsored this trial.
Other researchers include: Jeffrey Tyner, Ph.D.; Jutta Deininger, M.D., senior research assistant; Jonathan Van Dyke, research assistant; Marc Loriaux, M.D., Ph.D., assistant professor of pathology (anatomic pathology) and assistant professor of medicine (hematology/medical oncology); and Brian Druker, M.D., director of the OHSU Knight Cancer Institute, JELD-WEN Chair of Leukemia Research, Howard Hughes Medical Institute Investigator and a member of the National Academy of Sciences.
About the OHSU Knight Cancer Institute
The OHSU Cancer Institute is the only National Cancer Institute-designated center between Sacramento and Seattle. It comprises some 200 clinical researchers, basic scientists and population scientists who work together to translate scientific discoveries into longer and better lives for Oregon's cancer patients. In the lab, basic scientists examine cancer cells and normal cells to uncover molecular abnormalities that cause the disease. This basic science informs more than 300 clinical trials conducted at the OHSU Cancer Institute.
Oregon Health & Science University is the state’s only health and research university and Oregon’s only academic health center. OHSU is Portland's largest employer and the fourth largest in Oregon (excluding government), with 12,400 employees. OHSU's size contributes to its ability to provide many services and community support activities not found anywhere else in the state. It serves patients from every corner of the state, and is a conduit for learning for more than 3,400 students and trainees. OHSU is the source of more than 200 community outreach programs that bring health and education services to every county in the state.