Research Projects at OHSU Seek Volunteers

06/02/99    Portland, Ore.

The Oregon Stroke Center is seeking volunteers for two stroke prevention trials.

The first trial assesses whetehr reducing cholesterol in patients with normal cholesterol levels will prevent recent strokes. It has been shown that reducing cholesterol levels in patients with coronary artery disease (CAD) reduces the risk of recurrent stroke, even with normal baseline levels. This study will determine if it also is beneficial in patients without CAD. Patients who have had a stroke or transient ischemic attack (TIA) within six months without a history of CAD, and who have an LDL level between 100-190, are eligible.

The second stroke prevention trial is a vitamin intervention study that evaluates whether folic acid, B6 and B12 given to patients may lower levels of homocysteine and prevent redurrent strokes. Patients who have had a stroke within the past three months, and who have a homocysteine level greater than 10, are eligible.

The Oregon Stroke Center will work closely with each volunteer's primary care physician during these studies. All medications and care are provided at no charge to the patient.

Call 503 494-7225 for more information.

DIABETES TO BE STUDIED

New treatments that may help with the complications of diabetes are being tested in the Division o f Endocrinology, Diabetes and Clinical Nutrition. If you have Type 2 diabetes and are not using any medication or taking only oral diabetes medication, you could be eligible to take part in one of these research studies. Call 503 494-0557 for more information.

NON-SMOKERS NEEDED

Non-smokers between 18 and 34 years of age are needed for a nicotine EEG study. Study particpiants will take part in threee sessions--one 1-hour session and two 2.5 hour sessions. Participants will earn $5 an hour, plus the chance to win $75. Call 503 494-5650 for more information.

HORMONE REPLACEMENT STUDY SEEKS PARTICIPANTS
Are you a postmenopausal woman with questions about hormone replacement therapy? Are you concerned about osteoporosis and heart disease?

The Women's Health Research Unit is recruiting for several national research studies evaluating new options in hormone replacement therapy including natural progesterone and its effects on menopausal symptoms.

If you are a healthy woman between the ages of 40 and 65, you have not had a hysterectomy, and your last menstrual period was at leastsix months ago, you may be elibible to participate.

Qualifying participants will receive study medications, lab tests, a bone density screening and physical examinations at no cost. Particpants will be compensated for time and travel.

Call 503 494-3666 for more information.

PAIN MANAGEMENT CENTER TO STUDY SHINGLES
The Pain Management Center seeks people 18 years or older who have experienced shingles pain (post-herpetic neuralgia) for more than three months after healing of herpes zoster lesion. This five-week study will evaluate the efficacy and safety of an oral medication fo ruse in this condition. All study-related medication, clinic visits and testing will be provided at no cost. Call 503 494-5223 for more information.

ANTACID STUDY SUBJECTS WANTED
Is your antacid your best friend? If you are experiencing heartburn (especially after meals and while sleeping), this symptom my be due to irritation of your esophagus (the tube that connects your mouth to your stomach) by acid.

OHSU's Division of Gastroenterology is conducting a research study to investigate medications that may decrease your heartburn sypmtoms by decreasing the acid in your esophagus. THe study will involve at leaset 2,300 patients at more than 120 medical institutions throughout the United States.

Participants will receive study medication and a physical exam at no charge. Call 503 494-0368 or 503 721-1017 for more information.

DIABETES AND NUTRITION STUDY SEEKS PARTICIPANTS

Men and women with non-insulin dependent diabetes are needed for a nutrition study evaluating the effects of carbohydrates and fats on blood glucose control, hemoglobulin A-1C and cholesterol levels.

Frequent visits to the Clinical Research Center will be necessary. Participants will receive a free physical exam, laboratory tests and all food during the study. Personal results and an evaluation will be given when the study is completed. Call 503 494-6235 for more information.

PULMONARY INHALATION STUDY SEEKS SUBJECTS

The Division of Pulmonary and Critical Care seeks subjecst with chronic obstructive pulmonary disease (COPD) who are 40 years ad older for a 26-week research study investigating the safety and efficacy of powered futicasone and almeterol and a combination of the two medications administered via a diskus inhalation device.

Eligible subjects must have an established clinical history of COPD, a history of cough that produces sputum on most days for at least three months of the year, and cigarette smoking history of at least one pack a day for 20 years. You may also be eligible if you stopped smoking at least six months prior to screening.

Participants will receive $325 after completing the study. Call 503 494-6158 for more information.

SLEEP AND BIORHYTHM STUDY SEEKS PARTICIPANTS
Researchers are looking for volunteers between the ages of 65 and 90 for an experimental research study investigating the effects of the drug melatonin on human 24-hour rhythms and sleep.

Volunteers must be in good health, free of most medications and be very regular sleepers who normally go to bed at the same time each evening and awaken at the same time each morning, including weekends.

The study will involve regular admissions to the Clinical Research Center at OHSU and blood draws. Transportation will be provided if needed. Subjects will be paid for participating. Call 503 494-3402 for more information.

DIETARY STUDY SEEKS PARTICIPANTS
The Hypertension Research Clinic seeks generally healthy men and women between the ages of 22 and 70 to participate in a dietary research study. The purpose is to find out whether a diet rich in fruits, vegetables and low-fat dairy products will reduce the need for antihypertensive medication.

To qualify, you must have high blood pressure treated with one or two antihypertensive medications. Participants will receive a physical exam, laboratory studies, routine blood pressure monitoring and nutritional counseling at no cost to you. People completeing the study will receive $220 compensation for time and travel. Call 503 494-5179 for more information.

HEART DISEASE RESEARCH SEEKS PARTICIPANTS
A research study is being conducted to find out why premenopausal African-American women have more heart disease than white women.

Study coordinatorsare enrolling African-American and white women between the ages of 18 and 45 years hwo have regular menstrual periods and are in good general health. Volunteers must not have diabetes.

The research involves eating two kinds of meals--one low in fat and the other high in fat--then having the levels of triglyceride and a blood clotting factor measured for the rest of the day and the following morning. Participants will receive compensation of $100.

Call 503 494-6234 for more information.

SPERM DONORS SOUGHT
The Sperm Bank at the OHSU Andrology/Embryology Lab needs donors between the ages of 20 and 39 years. Compensation is provided. Call 503 418-3780 for more information.

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