Dr. Searles received his B.S. in Biochemistry and Biophysics from Oregon State University and his Ph.D. from the Department of Biological Chemistry at the University of California, Los Angeles. He was a post-doctoral fellow and staff scientist in the Division of Neuroscience at the Oregon National Primate Research Center, during which time he studied the structure and expression of G protein-coupled receptors. He moved to the ONPRC Division of Pathobiology and Immunology to investigate the genomic structure of primate gamma-2 herpesviruses, after which he was recruited to begin the ONPRC Bioinformatics Group. He established the OHSU Spotted Microarray Core, which operated for eight years prior to its closing in February of 2009. Dr. Searles is currently the director of both the OHSU Illumina Microarray Core and the OHSU Massively Parallel Sequencing Shared Resource and Associate Director for Informatics for the proposed OHSU Integrated Genomics Center. He holds the positions of Senior Staff Scientist in the Division of Pathobiology and Immunology and Affiliate Assistant Scientist at the Vaccine and Gene Therapy Institute.
Dr. Searles is focused on the operation of high throughput genomic resources and their applications in the study of gene expression and genetic variability. He has collaborated on a number of projects involving novel uses of DNA microarrays and on the development of user friendly approaches to high dimensional data analysis.