Michael Axthelm, DVM, PhD

Murray SM, Picker LJ, Axthelm MK and Linial ML.   Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression. J Virol 80: 663-670, 2006.

Dang X, Axthelm MK, Letvin NL and Koralnik IJ.   Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys.   J Virol 79: 1361-1366, 2005.

Axthelm MK, Koralnik IJ, Dang X, Wuthrich C. Rohme D, Stillman IE, Letvin NL.   Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys.   J Neuropathol Exp Neurol 63: 750-758, 2004.

Klaus Früh, PhD

Defilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA and Früh K. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.   J Virol 80: 1032-1037, 2006.

Defilippis VR and Früh K. Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3.   J Virol 79: 6419-6931, 2005.

Pande NT, Powers C, Ahn K and Früh K.   Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.   J Virol 79: 5786-5798, 2005.

Nerenberg BT, Taylor J, Bartee E, Gouveia K, Barry M and Früh K. The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories.   J Virol 79: 597-601, 2005.

Michael Jarvis, PhD

Ryckman BJ, Jarvis MA, Drummond DD, Nelson JA, Johnson DC.

Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion.

J Virol 80 :710-22, 2006.

Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Fruh K, Anders DG, Wong SW, Barry PA, Nelson JA.   A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism.   J Virol 78:12529-36, 2004.

Jarvis MA, Jones TR, Drummond DD, Smith PP, Britt WJ, Nelson JA, Baldick CJ.

Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication. J Virol 78: 285-93, 2004.

Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Fruh K.   Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.   J Virol 76 :8383-99, 2002.

Ashlee Moses, PhD

Raggo C, Ruhl R, McAllister S, Koon H, Dezube BJ, Früh K and Moses AV.   Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus.   Cancer Res 65: 5084-5095, 2005.

Henderson WW, Ruhl R, Lewis P, Bentley M, Nelson JA and Moses AV.   Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells.     J Virol 78: 4408-4420, 2004.

McAllister SC, Hansen SG, Ruhl R, Raggo CM, Defilippis VR, Greenspan D, Früh K and Moses AV. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells.   Blood 103: 3465-3473, 2004.

Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA and Früh K.   Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.   J Virol 76: 8383-8399, 2002.

Jay Nelson, PhD

Grey F, Antoniewicz A, Allen E, Saugstad J, McShea A, Carrington JC and Nelson JA. Identification and characterization of human cytomegalovirus-encoded microRNAs. J Virol 79:12095-12099, 2005.

Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI and Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles.   J Virol 79: 11943-11951, 2005.

Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD and Nelson JA. Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.   J Virol 78: 10960-10966, 2004.

Melnychuk RM, Streblow DN, Smith PP, Hirsch AJ, Pancheva D, and Nelson JA. Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol 78: 8382-8391, 2004.

Janko Nikolich-Zugich, MD, PhD

Messaoudi I, Warner J, Nikolich-Zugich Dr, Fischer M and Nikolich-Zugich J. Molecular, cellular and antigen requirements for development of age-associated T cell clonal expansions in vivo.   J Immunol 176: 301-308, 2006.

Lang A and Nikolich-Zugich J.   Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.   J Immunol 174: 2919-2925, 2005.

Messaoudi I, Lemoult J, Guevara-Patino JA, Metzner BM and Nikolich-Zugich J. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.   J Exp Med 200: 1347-1358, 2004.

Louis Picker, MD

Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, Sleath PR, Grabstein KH, Hosken NA, Kern F, Nelson JA and Picker LJ. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 5: 673-685, 2005.

Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, Sylwester AW, Walker JM, Siess DC, Piatak M Jr, Wang C, Allison DB, Maino VC, Lifson JD, Kodama T and Axthelm MK.   Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 15: 1299-1314, 2004.

Douek DC, Picker LJ and Koup RA. T cell dynamics in HIV-1 infection. Annu Rev Immunol 21: 265-304, 2003.

Pitcher CJ, Hagen SI, Walker JM, Lum R, Mitchell BL, Maino VC, Axthelm MK and Picker LJ.   Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168: 29-43, 2002.

Mark Slifka, PhD

Hammarlund E, Lewis MW, Carter SV, Amanna I, Hansen SG, Strelow LI, Wong SW, Yoshihara P, Hanifin JM and Slifka MK.   Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox.   Nat Med 11: 1005-1011, 2005.

Amanna I and Slifka MK.   Public fear of vaccination: separating fact from fiction.   Viral Immunol 18: 307-315, 2005.

Hammarlund E, Lewis MW, Hansen SG, Strelow LI, Nelson JA, Sexton GJ, Hanifin JM and Slifka MK.   Duration of antiviral immunity after small vaccination. Nat Med 9: 1131-1137, 2003.

Dan Streblow, PhD

Melnychuk RM, Smith P, Kreklywich CN, Ruchti F, Vomaske J, Hall L, Loh L, Nelson JA, Orloff SL and Streblow DN. Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration. J Virol 79: 10788-10795, 2005.

Streblow DN, Kreklywich CN, Smith P, Soule JL, Meyer C, Yin M, Beisser P, Vink C, Nelson JA and Orloff SL. Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33. Am J Transplant 5: 436-442, 2005.

Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD and Nelson JA. Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem 278: 50456-50465, 2003.

Streblow DN Soderberg-Naucler C, Viera J, Smith P, Wakabayashi E, Ruchti F, Mattison K, Altschuler and Nelson JA.   The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration.   Cell 99: 511-520, 1999.

Scott Wong, PhD

Langlais CL, Jones JM, Estep RD and Wong SW.   Rhesus rhadinovirus R15 encodes a functional homologue of human CD200. J Virol, in press, 2006.

Pratt CL, Estep RD and Wong SW.   Differential splicing of rhesus rhadinovirus R15 and ORF74 bi-cistronic transcripts during lytic infection and analysis of effects on production of vCD200 and vGPCR. J Virol 79: 3878-3882, 2005.

Hansen SG, Strelow LI, Franchi DC, Anders DG and Wong SW.   Complete sequence and genomic analysis of rhesus mytomegalovirus. J Virol 77: 6620-6636, 2003.

Estep RD, Axthelm MK and Wong SW.   A G-protein coupled receptor encoded by rhesus rhadinovirus is similar to ORF74 of Kaposi's sarcoma-associated herpesvirus. J Virol 77: 1738-1746, 2003.

Wong SW, Bergquam EP, Swanson RM, Lee FL, Shiigi SM, Avery NA, Fanton JW and Axthelm MK. Induction of B cell hyperplasia in simian immunodeficiency virus-infected rhesus macaques with the simian homologue of Kaposi's sarcoma-associated herpesvirus.   J Exp Med 190: 827-840, 1999.