Biodefense & Emerging Disease Publications

2011 Publications

1.  Aylor, D.L., Valdar, W., Foulds-Mathes, W., Buus, R.J., Verdugo, R.A., Baric, R.S., Ferrist, M.T., Frelinger, J.A., Heise, M., Frieman, M.B., Gralinski, L.E., et al., Genetic analysis of complex traits in the emerging Collaborative Cross Genome Res 2011 Aug;21(8):1213-22. Epub 2011 Mar 15. PMCID: PMC3149489.

2.  The Collaborative Cross Consortium (e.g., Aylor, D., Ferris, M., Gralinski, L., Heise, M., Katze, M., Baric, R., McWeeney, S., Pardo-Manuel de Villena, F)The Genome Architecture of the Collaborative Cross Mouse Genetics Reference Population. In Press, Genetics. 2011. PMCID Pending.

3.  Bolles M, Deming D, Long K, Agnihothram S, Whitmore A, Ferris M, Funkhouser W, Gralinski L, Totura A, Heise M, Baric RS. A double-inactived SARS-CoV Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge. J Virol. 2011. Dec;85(23):12201-15. Epub 2011 Sep 21. PMCID: PMC3209347.

4. Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinsk LE, Bradel-Tretheway BG, Bryan JT, Pardo-Manuel de Villena F, Baric RS, Katze MG, Heise M. McWeeney SK. Expression Quantitative Trait Loci for Differential Host Response to Influenza in pre-Collaborative Cross mice. 2011. Revised manuscript under re-review, Genetics.

5.  Bradel-Tretheway, BG, Mattiacio, JL, Krasnoselsky, A, Stevenson C, Purdy D, Dewhurst S, Katze MG. (2011) Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors, J. Virol. 85(17):8569. PMCID: PMC3165779

6.  Brien JD, Daffis S, Lazear HM, Cho H, Suthar MS, Gale M Jr, Diamond MS (2011) Interferon Regulatory Factor-1 (IRF-1) Shapes Both Innate and CD8 T Cell Immune Responses against West Nile Virus Infection. PLoS Pathog. 7:e1002230 PMCID: PMC3164650

7.  Cilloniz, C, Ebihara H, Ni, C, Neumann, G, Korth, MJ, Kelly, SM, Kawaoka, Y, Feldmann, H, and Katze MG. (2011) Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection, J. Virol.85(17):9060. PMCID: PMC3165855

8.  Gardner, C.L., C.W. Burke, S.T. Higgs, W.B. Klimstra and K.D. Ryman. (2011). STAT1-deficiency greatly exacerbates musculoskeletal inflammation in mice infected with a wild-type chikungunya virus strain but not with a heparan sulfate-binding vaccine strain. Submitted to Virology; currently being revised to address review critiques

9.  Goodman, AG, Tanner BCW, Chang ST, Esteban, M, and Katze, MG. (2011) Virus infection rapidly activates P58IPK pathway, delaying peak kinase activation to enhance viral replication, Virology. 417:27-36. PMCID: PMC3152592

10.  Halfmann, P., G. Neumann and Y. Kawaoka.  2011.  The Ebolavirus VP24 Protein Blocks Phosphorylation of p38 Mitogen-Activated Protein Kinase. J. Infect. Dis. 204:S953-956. PMCID: PMC3189987

11.  Ireton RC, Gale M Jr (2011) RIG-I Like Receptrors in Antiviral Immunity and Therapeutic Applications. Viruses. 3:906-919. PMCID: PMC3185779

12.  Lazear HM, Pinto AK, Vogt MR, Gale M Jr, Diamond MS (2011) Beta interferon controls West Nile virus infection and pathogenesis in mice. J. Virol. 85:7186-7194. PMCID: PMC3126609

13.  Li, Y, Li, J, Belisle, S, Baskin, CR, Tumpey, TM, Katze, MG. (2011) Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses. Virology. 421:105-113. PMCID: PMC3210927

14,  Peng, X, Gralinski, L, Ferris, MT, Frieman, MB, Thomas, MJ, Proll, S, Korth, MJ, Tisoncik, JR, Heise, M, Luo, S, Schroth, GP, Tumpey, TM, Li, C, Kawaoka Y, Baric, RS, Katze, MG. (2011) Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection, mBio. 00198-11 15 Nov 2011 PMCID: PMC3221602

15.  Perwitasari O, Cho H, Diamond MS, Gale M Jr (2011) IFIT2 restriction of WNV infection through IKKε phosphorylation of STAT1. J Biol Chem In Press.

16.  Ramos HJ, Negash A, Suthar MS, Blahnik G, Brassil M, Sodhi K, Gale M Jr (2011) IL-1 signaling and the NLRP3 Inflammasome are required for CNS-specific protective immunity against West Nile Virus. Submitted.

17.  Rockx, B., Feldmann, F., Brining, D., Gardner, D., LaCasse, R., Kercher, L., Long, D., Rosenke, R., Virtaneva, K., Sturdevant, D.E., Porcella, S.F., Matton, J., Parnell, M., Baric, R.S. and Feldmann, H. Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques. Plos One. 2011 Apr 20;6(4):e18558. PMCID: PMC3080360.

18.  Smithey, M.J., K.R. Renkema, B. D. Rudd and J. Nikolich-Zugich. 2011. Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to increase susceptibility to L. monocytogenes in old mice. Eur. J. Immunol. 41:1352.

19.  Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K. (2011) Inhibition of Dengue Virus Infections in Cell Cultures and in AG129 Mice by an siRNA Targeting a Highly Conserved Sequence. Journal of Virology, 85:10154-10166 PMCID: PMC3196423

20.  Suthar MS, Ramos HJ, Brassil M, Netland J, Chappell C, Blahnik G, McMillan A, Clark, E.A., Bevan, M.J., Gale, M. Jr. (2011) The RIG-I Like Receptor LGP2 Regulates CD8 T Cell Survival and Fitness. Submitted

21.  Uhrlaub, J.L., J.D. Brien, D.G. Widman, P.W. Mason and J. Nikolich-Zugich. 2011.
Repeated in vivo stimulation of T- and B cell responses in old mice generates protective immunity against lethal West Nile virus (WNV) encephalitis. J. Immunol. 186:3882-91. PMID:21339368

2010 Publications

1.  Amanna IJ, Slifka MK (2010). Contributions of humoral and cellular immunity to vaccine induced protection in humans.  Virology, in press.

2.  Basso LR, Bartiss A, Mao Y, Gast C, Coelho P, Snyder M, Wong B.  Transformation of Candida albicans with a synthetic hygromycin B resistance gene.  Yeast, published online 24 Aug 2010.
 
3.  Daffis S, Szretter K J, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V,. Klimstra WB, Pierson TC, Buller RM, Gale M, Shi PY, Diamond MS. (2010). 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature: In press.

4.  Daffis, S., M. S. Suthar, K. J. Szretter, M. Gale, Jr., and M. S. Diamond. 2009. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog 5:e1000607.

5.  Gerlach C, van Heijst JWJ, Swart E, Sie D, Armstrong N, Kerkhoven RM, Zehn D, Bevan MJ, K. Schepers and T. N. M. Schumacher (2010) One naïve T cell-multiple fates in CD8+ T cell differentiation.J. Exp. Med., 206: 1235-1246. PMCID: PMC2882844

6.   Haberthur K, Meyer C, Messaoudi I (2011). Improving immunity in the elderly; lesson from nonhuman primates models, AGE special issue, in press

7.  Peng X, Chan EY, Li Y, Diamond DL, Korth MJ, Katze MG. (2009) Virus-host interactions: from systems biology to translational research, Curr Opin Microbiol 12, 432-438. PMCID: 2742299

8.  Peng X, Gralinski L, Armour CD, Ferris MT, Thomas MJ, Proll S, Bradel-Tretheway BG, Korth MJ, Castle JC, Biery MC, Bouzek HK, Haynor DR, Frieman MB, Heise M, Raymond CK, Baric RS, Katze MG.  Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio. 2010 Oct 26;1(5). pii: e00206-10.

9. Shum D., Smith JL, Hirsch AJ, Bhinder B, Radu C, Stein DA, Nelson JA, Früh K, Djaballah H. High Content Assay to Identify Inhibitors of Dengue Virus Infection. Assay and Drug Development Technologies (2010) 8:553-570.

10. Safronetz, D., Hegde, N.R., Ebihara, H., Denton, M., Kobinger, G.P., St.Jeor, S., Feldmann, H., Johnson, D.C. (2009) Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with Andes virus. J. Virol. 83(14):7285-7295.

11. Suthar, M. S., D. Y. Ma, S. Thomas, J. M. Lund, N. Zhang, S. Daffis, A. Y. Rudensky, M. J. Bevan, E. A. Clark, K. J. Murali-Krishna, M. S. Diamond, and M. Gale. 2010. IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog 6:e1000757.

12.  Szretter KJ, Daffis S, Patel J, Suthar MS, Klein RS, Gale M, Jr., Diamond M S. (2010). The innate immune adaptor molecule MyD88 restricts West Nile replication and spread in neurons of the central nervous system. J Virol. In press.

13. White LK, Sali T, Alvarado D, Gatti E, Pierre P, Streblow D, DeFilippis VR. Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and PKR-Independent Translational Shutoff. J. Virology [Epub October, 2010]. PMID: 20962078

14. Zehn D, Turner MJ, Lefrancois L, Bevan MJ. (2010) Lack of original antigenic sin in recall CD8+ T cell responses.  J. Immunol., 84: 6320- 6326. PMID: 20439913

15. Zornetzer GA, Frieman MB, Rosenzweig E, Korth MJ, Page C, Baric RS, Katze MG.  Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection.  J Virol. 2010 Nov;84(21):11297-309. Epub 2010 Aug 11.

2009 Publications

1. Amanna, I.J., and M.K. Slifka (2009). Wanted, Dead or Alive: New Viral Vaccines.  Antiviral Research 84:119-130. PMCID: 2791678

2. Cilloniz, C., Shinya, K., Peng, X., Korth, M. J., Proll, S. C., Aicher, L. D., Carter, V. S., Chang, J. H., Kobasa, D., Feldmann, F., Strong, J. E., Feldmann, H., Kawaoka, Y., and Katze, M. G. (2009) Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes, PLoS Pathog 5, e1000604. PMCID: 2745659

3. Daffis, S., M. S. Suthar, K. J. Szretter, M. Gale, Jr., and M. S. Diamond. 2009. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog. 2009 Oct;5(10):e1000607. PMCID: 2747008

4. Peng, X., Chan, E. Y., Li, Y., Diamond, D. L., Korth, M. J., and Katze, M. G. (2009) Virus-host interactions: from systems biology to translational research, Curr Opin Microbiol 12, 432-438. PMCID: 2742299

5. Suthar, M.S, D. Ma, S. Thomas, J.M. Lund, N. Zhang, S. Daffis, A.Y. Rudensky, M.J. Bevan, E.A. Clark, K. Murali-Krishna, M. S. Diamond, and M. Gale Jr. 2009.  IPS-1 is essential for the control of West Nile virus infection and immunity.  PLoS Pathogens. 2010 Feb 5;6(2):e1000757 PMCID: 2816698.

6. Tisoncik, J.R., S.E. Belisle, D.L. Diamond, M.J. Korth, and M.G. Katze. (2009). Is systems biology the key to preventing the next pandemic? Future Virol. 2009 Nov 1;4(6):553-561. PMCID: 2843927

7. Zehn, D., S. Y. Lee and M. J. Bevan (2009)  Complete but curtailed T cell response to very low affinity antigen.  Nature,  458: 211-214. PMCID 2735344

2008 Publications

Ansong, C., H. Yoon, A. D. Norbeck, J. K. Gustin, J. E. McDermott, H. M. Mottaz, J. Rue, J. N. Adkins, F. Heffron, and R. D. Smith. 2008. Proteomics analysis of the causative agent of typhoid fever. J. Proteome Res. 7:546-557. PMID: 18166006

Baas T., A. Roberts, T. H. Tea, L. Vogel, J. Chen, T. M. Tumpey, M. G. Katze, and K. Subbarao. 2008. Genomic analysis reveals age dependent innate immune responses to SARS  coronavirus.  J. Virol.  82:9465-9476. PMID: 18632870 PMCID: PMC2546950

Baric, R. S. 2008. SARS-CoV: Lessons for global health.  Virus Res. 133:1-3.  PMID: 17467837 PMCID: PMC2633111

Callister, S. J., L. A. McCue, J. E. Turse, M. E. Monroe, K. J. Auberry, R. D. Smith, J. Adkins, and M. S. Lipton. 2008. Comparative bacterial proteomics: Analysis of the core genome concept.  PLoS ONE 3:e1542. PMID: 18253490 PMCID: PMC2213561

Chachu, K. A, D. W. Strong, A. D. LoBue, C. E. Wobus, R. S. Baric, and H. W. Virgin.  2008. Antibody is critical for the clearance of MNV infection.  J. Virol. 82:6610-6617. PMID: 18417579 PMCID: PMC2447077

Daffis, S., M. A. Samuel, M. S. Suthar, B. C. Keller, M. Gale, Jr., and M. S. Diamond. 2008. Interferon regulatory factor (IRF)-7 induces the antiviral interferon (IFN)-{alpha} response and protects against lethal West Nile virus infection. J. Virol. 82:8465-8475. PMID: 18562536 PMCID: PMC2519659

Donaldson, E., L. Lindesmith, A. LoBue, and R. S. Baric.  2008.  Norovirus pathogenesis: Mechanisms of persistence and immune evasion in human populations.  Immunol. Rev. 225:190-211. PMID: 18837783

Dubois, M. and M. K. Slifka. 2008.  Retrospective analysis of monkeypox infection.  Emerg. Inf. Dis. 14:592-599.  PMID: 18394277 PMCID: PMC2570942

Fredericksen, B., B. Keller, J. Fornek, M. G. Katze, and M. Gale, Jr. 2008. Establishment and maintenance of the innate antiviral response to West Nile virus involves both RIG-I and MDA5 signaling through IPS-1. J. Virol. 82:609-616. PMID: 17977974 PMCID: PMC2224571

Frieman, M., and R. S. Baric.  2008.  Mechanisms of SARS pathogenesis and innate immune modulation. Microbiol. Mol. Biol. Rev. 72:672-685.  PMID: 19052324 PMCID: PMC2593566

Frieman, M., M. Heise, and R. Baric. 2008. SARS coronavirus and innate immunity.  Virus Res. 133:101-112. PMID: 17451827 PMCID: PMC2292640

Gambotto, A., S. M. Barratt-Boyes, M. D. de Jong, G. Neumann, and Y. Kawaoka. 2008. Human infection with highly pathogenic H5N1 influenza virus. Lancet 371:1464-1475. PMID: 18440429

Halfmann P., J. H. Kim, H. Ebihara, T. Noda, G. Neumann, H, Feldmann, and Y. Kawaoka. 2008. Generation of biologically contained Ebola viruses. Proc. Natl. Acad. Sci. USA. 105:1129-1133. PMID: 18212124 PMCID: PMC2234103

Hammarlund, E., A. Dasgupta, K. Frueh, and M. K. Slifka. 2008. Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation.  Proc. Natl. Acad. Sci. USA. 105:14567-14572. PMID: 18796610 PMCID: PMC2567221

Hammarlund, E., M. W. Lewis, J. Hanifin, E. Simpson, N. Carlson, and M. K. Slifka. 2008. Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment. Vaccine.26:430-439. PMID: 18083278 PMCID: PMC2323604

Hao, L., A. Sakurai, T. Watanabe, E. Sorensen, C. A. Nidom, M. A. Newton, P. Ahlquist, and Y. Kawaoka. 2008. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature. 454:890-893.  PMID: 18615016 PMCID: PMC2574945

Ishikawa, T., D. G. Widman, N. Bourne, E. Konishi, and P. W. Mason. 2008. Construction and evaluation of a chimeric pseudoinfectious virus vaccine to prevent Japanese encephalitis. Vaccine. 26:2772-2781. PMID: 18433947

Itoh, Y., H. Ozaki, H. Tsuchiya, K. Okamoto, R. Torii, Y. Sakoda, Y. Kawaoka, K. Ogasawara, and H. Kida. 2008. A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine. 26:562-572. PMID: 18164788

Iwatsuki-Horimoto, K., Y. Hatta, M. Hatta, Y. Muramoto, H. Chen, Y. Kawaoka, and T. Horimoto. 2008. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Res. 135:161-165. PMID: 18455827 PMCID: PMC2474793

Jones, J., I. Messaoudi, R. Estep, B. Orzechowska, and S. Wong. 2008. Monkeypox viral chemokine inhibitor MPV vCCI, a potent inhibitor of rhesus macrophage inflammatory protein-1. Cytokine. 43:220-228.  PMID: 18639466  PMCID: PMC2547134

Jiao, P., G. Tian, Y. Li, G. Deng, Y. Jiang, C. Liu, W. Liu, Z. Bu, Y. Kawaoka, and H. Chen.  2008. A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J. Virol. 82:1146-1154.  PMID: 18032512 PMCID: PMC2224464

Katze, M. G., J. L. Fornek, R. E. Palermo, K.-A. Walters, and M. J. Korth. 2008. Innate immune modulation by RNA viruses: Emerging insights from functional genomics. Nat. Rev. Immunol. 8:644-654.  PMID: 18654572

Krishnan, M.N., A. Ng, B. Sukumaran, F. D. Gilfoy, P. D. Uchil, H. Sultana, A. L. Brass, R. Adametz, M. Tsui, F. Qian, R. R. Montgomery, S. Lev, P. W. Mason, R. A. Koski, S. J. Elledge, R. J. Xavier, H. Agaisse, and E. Fikrig. 2008. RNA interference screen for human genes associated with West Nile virus infection. Nature.  455:242-245.  PMID: 18690214

Lamirande, E.W., M. L. Dediego, A. Roberts, J. P. Jackson, E. Alvarez, T. Sheahan, W. J. Shieh, S. R. Zaki, R. Baric, L. Enjuanes, and K. Subbarao. 2008. A live attenuated SARS coronavirus is immunogenic and efficacious in golden Syrian hamsters.  J. Virol. 82:7721-7724. PMID: 18463152 PMCID: PMC2493341

Lindesmith, L., E. Donaldson, A. Lobue, J. Cannon, J. Vinje, and R. S. Baric. 2008. Mechanisms of zoonotic Severe Acute Respiratory Syndrome Coronavirus host range expansion in human airway epithelium. J. Virol. 82:2274–2285. PMID: 18094188 PMCID: PMC2258931

Loo, Y. M., J. Fornek, N. Crochet, G. Bajwa, O. Perwistasari, L. Martinez-Sobrido, S. Akira, M. Gill, A. Garcia-Sastre, M. G. Katze, and M. Gale, Jr. 2008. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J. Virol. 82:335-345. PMID: 17942531 PMCID: PMC2224404

Manes, N. P., R. D. Estep, H. M. Mottaz, R. J. Moore, T. R. Clauss, M. E. Monroe, X. Du, J. N. Adkins, S. W. Wong, and R. D. Smith. 2008. Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions. J. Proteome Res. 7:960-968.  PMID: 18205298 PMCID: PMC2517256

McRoy, W., and R. S. Baric. 2008. Amino acid substitutions in the S2 subunit of mouse hepatitis virus variant V51 encode determinants of host range expansion. J. Virol. 82:2274-2285. PMID: 18032498 PMCID: PMC2224421

Medigeshi, G.R., A. J. Hirsch, D. N. Streblow, J. Nikolich-Zugich, and J. A. Nelson. 2008. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphabeta 3 integrins.  J. Virol. 82:5212-5219. PMID: 18385233 PMCID: PMC2395215

Marsolais, D., B. Hahm, K. H. Edelmann, K. B. Walsh, M. Guerrero, Y. Hatta, Y. Kawaoka, E. Roberts, M. B. Oldstone, and H. Rosen. 2008. Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol. Pharmacol. 74:896-903. PMID: 18577684 PMCID: PMC2574812

Murakami, S., T. Horimoto, S. Yamada, S. Kakugawa, H. Goto, and Y. Kawaoka.  2008. Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus: Its application for H5N1 vaccine production. J. Virol. 82:1605-1609. PMID: 18045936 PMCID: PMC2224466

Pacciarini, F., S. Ghezzi, F. Canducci, A. Sims, M. Sampaolo, E. Ferioli, M. Clementi, G. Poli, P.-G. Conaldi, R. S. Baric, and E. Vicenzi.  2008.  Persistent replication of Severe Acute Respiratory  Syndrome Coronavirus (SARS-CoV) in human tubular kidney cells selects for adaptive mutations in the membrane protein. J. Virol. 82:5137-5144. PMID: 18367528 PMCID: PMC2395189

Pitaluga, A. N., P.W. Mason, and Y. M. Traub-Cseko. 2008. Non-specific antiviral response detected in RNA-treated cultured cells of the sandfly, Lutzomyia longipalpis. Dev. Comp. Immunol. 32:191-197. PMID: 17706772

Rodland, K. D., J. N. Adkins, C. Ansong, S. Chowdhury, N. P. Manes, L. Shi, H. Yoon, R. D. Smith, and F. L. Heffron. 2008. Use of high-throughput mass spectrometry to elucidate host-pathogen interactions in Salmonella.  Future Microbiol. 3:625-634. PMID: 19072180

Sacks, J. A. and M. J. Bevan. 2008. TRAIL-deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help.  J. Immunol. 180:4570-4576. PMID:18354179

Sakabe, S., Y. Sakoda, Y. Haraguchi, N. Isoda, K. Soda, H. Takakuwa, K. Saijo, A. Sawata, K. Kume, J. Hagiwara, K. Tuchiya, A. Lin, R. Sakamoto, T. Imamura, T. Sasaki, N. Kokumai, Y. Kawaoka, and H. Kida. 2008. A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens. Vaccine. 26:2127-2134. PMID: 18346824

Sawai, T., Y. Itoh, H. Ozaki, N. Isoda, K. Okamoto, Y. Kashima, Y. Kawaoka, Y. Takeuchi, H. Kida, and K. Ogasawara. 2008. Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology. 124:155-165. PMID: 18205793 PMCID: PMC2566620

Sheahan, T., B. Rockx, E. Donaldson, D. Corti, and R. Baric.  2008. Pathways of cross species transmission of synthetically reconstructed zoonotic SARS-CoV.  J. Virol. 82:8721-8732. PMID: 18579604 PMCID: PMC2519660

Sheahan, T., B. Rockx, E. Donaldson, A. Sims, R. Pickles, and R. S. Baric. 2008. Mechanisms of zoonotic SARS-CoV host range expansion in human airway epithelium. J. Virol. 82:2274-2285. PMID: 18094188 PMCID: PMC2258931

Sparks, J. S., E. F. Donaldson, X. Lu, R. S. Baric, and M. R. Denison. 2008.  A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.  J. Virol. 82:5999-6008. PMID: 18385240 PMCID: PMC2395152

Sugaya, N., D. Tamura, M. Yamazaki, M. Ichikawa, C. Kawakami, Y. Kawaoka, and K. Mitamura. 2008. Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children. Clin. Infect. Dis. 47:339-345. PMID: 18582202

Suzuki, R., R. Fayzulin, I. Frolov, and P. W. Mason.  2008. Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: use in safer propagation of a novel vaccine candidate.  J. Virol. 82:6942-6951.  PMID: 18480453 PMCID: PMC2446964

Takhasi, K., M. Yoneyama, T. Nishihori, R. Hirai, H. Kumeta, R. Narita, F. Inagaki, M. Gale, Jr., and T. Fujita. 2008. Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.  Mol. Cell. 29:1-13. PMID: 18242112

Teunis, P., C. Moe, P. Liu, S. Miller, L. Lindesmith, R. Baric, J. Le Pendu, and R. L. Calderon. 2008. Norwalk virus: How infectious is it.  J. Med. Virol. 80:1468-1476. PMID: 18551613

Watanabe, T., S. Watanabe, J. H. Kim, M. Hatta, and Y. Kawaoka. 2008. Novel approach to the development of effective H5N1 influenza A virus vaccines: Use of M2 cytoplasmic tail mutants.  J. Virol. 82:2486-2492. PMID: 18160446 PMCID: PMC2258945

Widman, D. G., T. Ishikawa, R. Fayzulin, N. Bourne, and P. W. Mason. 2008. Construction and characterization of a second-generation pseudoinfectious West Nile virus vaccine propagated using a new cultivation system. Vaccine. 26:2762-2771.  PMID: 18423946

Widman, D. G., I. Frolov, and P. W. Mason. 2008. Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses.  Adv. Virus Res. 72:77-126.  PMID: 19081489

Williams M. A., E. V. Ravkov, and M. J. Bevan.  2008. Rapid culling of the CD4+ T cell response in the transition from effector to memory.  Immunity. 28:533-545. PMID:18356084 PMCID: PMC2391296

Yamayoshi, S., T. Noda, H. Ebihara, H. Goto, Y. Morikawa, I. S. Lukashevich, G. Neumann, H. Feldmann, and Y. Kawaoka. 2008.  Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport. Cell Host Microbe. 3:168-177. PMID: 18329616 PMCID: PMC2330329

Zhu, Q., H. Yang, W. Chen, W. Cao, G. Zhong, P. Jiao, G. Deng, K. Yu, C. Yang, Z. Bu, Y. Kawaoka, and H. Chen. 2008. A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens. J. Virol. 82:220-228. PMID: 17942562 PMCID: PMC2224367

2007 Publications

Barklis, E., A. Still, M. Sabri, A. Hirsch, J. Nikolich-Zugich, J. Brien, T. Dhenub, I. Scholz, and A. Alfadhli. 2007. Sultam thiourea inhibition of West Nile virus. Antimicrob. Agents Chemother.  51:2642-2645. PMID:  17452483 PMCID: PMC1913232

Baskin, C. R., H. Bielefeldt-Ohmann, A. García-Sastre, T. M. Tumpey, H. N. Van, V. S. Carter, M. J. Thomas, S. Proll, A. Solórzano, R. Billharz, J. L. Fornek, S. Thomas, C. H. Chen, E. A. Clark, M. K. Kaja, and M. G. Katze. 2007. Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J. Virol. 81:11817-11827. PMID: 17715226 PMCID: PMC2168783

Bourne, N., F. Scholle, M. C. Silva, S. L. Rossi, N. Dewsbury, B. Judy, J. B. De Aguiar, M. A. Leon, D. M. Estes, R. Fayzulin, and P. W. Mason. 2007. Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production. J. Virol. 81:9100-9108. PMID:17567689 PMCID: PMC1951458

Brien, J. D., J. L. Uhrlaub, and J. Nikolich-Zugich. 2007. Protective capacity and epitope specificity of CD8+ T-cells responding to lethal West Nile virus infection. Eur. J. Immunol.  37:1855-1863. PMID: 17559175

Daffis, S., M. A. Samuel, B. C. Keller, M. Gale, Jr., and M. S. Diamond. 2007. Cell-specific IRF-3 responses protect against West Nile virus infection by IFN-dependent and independent mechanisms. PLoS Pathogens. 3:e106.  PMID: 17676997 PMCID: PMC1933455

de Lang, A., T. Baas, T. Teal, L. M. Leijten, B. Rain, A. D. Osterhaus, B. L. Haagmans, and M. G. Katze. 2007. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog. 3:e112. PMID: 17696609 PMCID: PMC1941749

Ebihara, H., S. Theriault, G. Neumann, J. B. Alimonti, J. B. Geisbert, L. E. Hensley, A. Groseth, S. M. Jones, T. W. Geisbert, Y. Kawaoka, and H. Feldmann. 2007. In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein.  J. Infect. Dis. 196 Suppl 2:S313-322.  PMID: 17940966

Feldmann, H., T. Geisbert, and Y. Kawaoka. 2007. Filoviruses: Recent advances and future challenges.  J. Infect. Dis. 196 Suppl 2:S129-130. PMID:  17940939

Fornek, J. L., M. J. Korth, and M. G. Katze. 2007. Use of functional genomics to understand influenza-host interactions. Adv. Virus Res. 70:81-100. PMID: 17765704
Fredericksen, B., B. Keller, J. Fornek, M. G. Katze, and M. Gale, Jr. 2007. Establishment and maintenance of the innate antiviral response to West Nile virus involves both RIG-I and MDA5 signaling through IPS-1. J. Virol. 82:609-616. PMID: 17977974 PMCID: PMC2224571

Frieman, M., B. Yount, M. Heise, S. A. Kopecky-Bromberg, P. Palese, and R. S. Baric. 2007. Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J. Virol. 81:9812-9924. PMID: 17507479 PMCID: PMC1933338

Garulli, B., M. Meola, M. G. Stillitano, Y. Kawaoka, and M. R. Castrucci. 2007. Efficient vagina-to-lower respiratory tract immune trafficking in a murine model of influenza A virus infection. Virology. 361:274-282. PMID:  17222437

Gilfoy, F. D. and P. W. Mason. 2007. West Nile virus-induced IFN production is mediated by the double-stranded RNA-dependent protein kinase, PKR. J. Virol. 81:11148-11158. PMID: 17686861 PMCID: PMC2045557

Girard, Y. A., B. S. Schneider, C. E. McGee, J. Wen, V. C. Han, V. Popov, P. W. Mason, and S. Higgs. 2007. Salivary gland morphology and virus transmission during long-term cytopathologic West Nile virus infection in culex mosquitoes. Am. J. Trop. Med. Hyg. 76:118-128. PMID: 17255239

Goodman, A. G., J. A. Smith, S. Balachandran, O. Perwitasari, S. C. Proll, M. J. Thomas, M. J. Korth, G. N. Barber, L. A. Schiff, and M. G. Katze. 2007. The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J. Virol. 81:2221-2230. PMID: 17166899 PMCID: PMC1865913

Gu, B., P. Mason, L. Wang, P. Norton, N. Bourne, R. Moriarty, A. Mehta, M. Despande, R. Shah, and T. Block. 2007. Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus. Antivir. Chem. Chemother. 18:49-59. PMID: 17354651

Guo, C.T., N. Takahashi, H. Yagi, K. Kato, T. Takahashi, S. Q. Yi, Y. Chen, T. Ito, K. Otsuki, H. Kida, Y. Kawaoka, K. I. Hidari, D. Miyamoto, T. Suzuki, and Y. Suzuki. 2007. The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors. Glycobiology 17:713-724.  PMID:  17389652

Hatakeyama, S., N. Sugaya, M. Ito, M. Yamazaki, M. Ichikawa, K. Kimura, M. Kiso, H. Shimizu, C. Kawakami, K. Koike, K. Mitamura, and Y. Kawaoka. 2007. Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors.  JAMA 297:1435-1442.  PMID:  17405969

Hatta, M., Y. Hatta, J. H. Kim, S. Watanabe, K. Shinya, T. Nguyen, P. S. Lien, W. M. Le, and Y. Kawaoka. 2007. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.  PLoS Pathog. 3:1374-1379.  PMID:  17922570 PMCID: PMC2000968

Hatta, M., and Y. Kawaoka. 2007. Molecular determinants associated with high virulence of influenza A virus. Tanpakushitsu Kakusan Koso. 52:1237-1241. PMID: 17824246

Horimoto. T., S. Murakami, Y. Muramoto, S. Yamada, K. Fujii, M. Kiso, K. Iwatsuki-Horimoto, Y. Kino, and Y. Kawaoka. 2007. Enhanced growth of seed viruses for H5N1 influenza vaccines. Virology. 15:366(1):23-27.  PMID: 17651774

Kamimura, D. and M. J. Bevan.  2007. Naïve CD8+ T cells differentiate into protective memory-like cells following IL-2/anti-IL-2 complex treatment in vivo. J. Exp. Med. 204:1803-1812. PMID:  17664293 PMCID: PMC2118678

Keller, B. C., C. L. Johnson, A. K. Erickson, and M. Gale, Jr. 2007. Innate immune evasion by hepatitis C virus and West Nile virus. Cytokine Growth Factor Rev. 5-6:535-544. PMID:  17702639

Kobasa, D., S. M. Jones, K. Shinya, J. C. Kash, J. Copps, H. Ebihara, Y. Hatta, J. H. Kim, P. Halfmann, M. Hatta, F. Feldmann, J. B. Alimonti, L. Fernando, Y. Li, M. G. Katze, H. Feldmann, and Y. Kawaoka. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319-323.  PMID:  17230189

Kurosaki, Y., A. Takada, H. Ebihara, A. Grolla, N. Kamo, H. Feldmann, Y. Kawaoka, and J. Yasuda. 2007. Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification. J. Virol. Methods. 141:78-83.  PMID: 17194485

Loo, Y.-M., and M. Gale, Jr. 2007. Viral regulation and evasion of the host response. Curr. Top. Microbiol. Immunol. 316:295-313. PMID: 17969453

Malathi, K., B. Dong, M. Gale, Jr., and R. Silverman. 2007. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature. 448:816-819. PMID:  17653195

Manes, N. P., J. K. Gustin, J. Rue, H. M. Mottaz, S. O. Purvine, A. D. Norbeck, M. E. Monroe, J. S. Zimmer, T. O. Metz, J. N.  Adkins, R. D. Smith, and F. Heffron.  2007. Targeted protein degradation by Salmonella under phagosome-mimicking culture conditions investigated using comparative peptidomics. Mol. Cell Proteomics. 6:717-727. PMID: 17228056

Medigeshi, G. R., A. M. Lancaster, A. J. Hirsch, T. Briese, W. I. Lipkin,  V. Defilippis, K. Fruh, P. W. Mason, J. Nikolich-Zugich, and J. A. Nelson.  2007. West Nile virus infection activates the unfolded protein response leading to CHOP induction and apoptosis. J. Virol. 81:10849-10860. PMID: 17686866 PMCID: PMC2045561

Morrison, T. E., R. J. Fraser, P. N. Smith, S. Mahalingam, and M. T. Heise. 2007. Complement contributes to inflammatory tissue destruction in a mouse model of Ross River virus-induced disease. J. Virol. 81:5132-5143. PMID:  17314163 PMCID: PMC1900244

Neumann, G., T. W. Geisbert, H. Ebihara, J. B. Geisbert, K. M. Daddario-DiCaprio, H. Feldmann, and Y. Kawaoka. 2007. Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates. J. Virol. 81:2995-2998. PMID:  17229700 PMCID: PMC1866002

Nochi, T., Y. Yuki, A. Matsumura, M. Mejima, K. Terahara, D. Y. Kim, S. Fukuyama, K. Iwatsuki-Horimoto, Y. Kawaoka, T. Kohda, S. Kozaki, O. Igarashi, and H. Kiyono. 2007.  A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.  J. Exp. Med. 204:2789-2796.  PMID:  17984304 PMCID: PMC2118513

Noda, T., P. Halfmann, H. Sagara, and Y. Kawaoka.  2007. Regions in Ebola virus VP24 that are important for nucleocapsid formation.  J. Infect. Dis. 196 Suppl 2:S247-250.  PMID:  17940956

Noda, T., S. Watanabe, H. Sagara, and Y. Kawaoka. 2007. Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus. J. Virol. 81:3554-3562. PMID: 17229682 PMCID: PMC1866061

Ozawa, M., K. Fujii, Y. Muramoto, S. Yamada, S. Yamayoshi, A. Takada, H. Goto, T. Horimoto, and Y. Kawaoka. 2007. Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication. J. Virol. 81:30-41. PMID: 17050598 PMCID: PMC1797272

Ozawa, M., H. Goto, T. Horimoto, and Y. Kawaoka. 2007. An adenovirus vector-mediated reverse genetics system for influenza A virus generation. J. Virol. 81:9556-9559. PMID: 17596315 PMCID: PMC1951417

Rigoni, M., K. Shinya, A. Toffan, A. Milani, F. Bettini, Y. Kawaoka, G. Cattoli, and I. Capua. 2007. Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice. Virology. 364:28-35.  PMID:  17408714

Roberts, A., D. Deming, C. D. Paddock, A. Cheng, B. Yount, L. Vogel, B. D. Herman, T. Sheahan, M. Heise, G. L. Genrich, S. R. Zaki, R. Baric, and K. Subbarao. 2007. A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice. PLOS Pathogens. 3:23-37.  PMID: 17222058 PMCID: PMC1769406

Rockx, B., T. Sheahan, E. Donaldson, J. Harkema, A. Sims, M. Heise, R. Pickles, M. Cameron, D. Kelvin, and R. Baric. 2007. Synthetic reconstruction of zoonotic and early human SARS-CoV isolates that produce fatal disease in aged mice. J. Virol. 81:7410-23. PMID: 17507479 PMCID: PMC1933338

Rossi, S. L., R. Fayzulin, N. Dewsbury, N. Bourne, and P. W. Mason. 2007. Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo. Virology. 384:184-195. PMID: 17382364

Saito, T., and M. Gale, Jr. 2007. Principles of intracellular viral recognition. Curr. Opin. Immunol. 19:17-23. PMID:  17118636

Saito, T., R. Hirai, Y.-M. Loo, D. Owen, C. L. Johnson, S. C. Sinha, S. Akira, T. Fujita, and M. Gale. Jr. 2007. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. U.S.A. 104:582-587.  PMID: 17190814 PMCID: PMC1766428

Sawada, T., T. Hashimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishida, and M. Kiso. 2007. Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor.  Biochem. Biophys. Res. Commun. 355:6-9. PMID:  17292854

Shimojima, M., Y. Ikeda, and Y. Kawaoka. 2007. The mechanism of Axl-mediated Ebola virus infection.  J. Infect. Dis. 196:S259-263.  PMID:  17940958

Shinya, K., S. Watanabe, T. Ito, N. Kasai, and Y. Kawaoka. 2007. Adaptation of an H7N7 equine influenza A virus in mice. J. Gen. Virol. 88:547-553.  PMID:  17251573

Shustov, A. V., P. W. Mason, and I. Frolov. 2007. Production of pseudoinfectious yellow fever virus with two-component genome. J. Virol. 81:11737-11748. PMID: 17715227 PMCID: PMC2168813

Silva, M. C., A. Guerrero-Plat, F. D. Gilfoy, R. P. Garofalo, and P. W. Mason. 2007. Differential activation of human monocyte-derived and plasmacytoid dendritic cells by West Nile virus generated in different host cells. J. Virol. 81:13640-13648. PMID: 17913823 PMCID: PMC2168853

Sugaya, N., K. Mitamura, M. Yamazaki, D. Tamura, M. Ichikawa, K. Kimura, C. Kawakami, M. Kiso, M. Ito, S. Hatakeyama, and Y. Kawaoka. 2007. Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin. Infect. Dis. 44:197-202.  PMID:  17173216

Suzuki, R., L. de Borba, C. N. Duarte Dos Santos, and P. W. Mason 2007. Construction of an infectious cDNA clone for a Brazilian prototype strain of dengue virus type 1: Characterization of a temperature-sensitive mutation in NS1. Virology. 363:374-383. PMID: 17382364 PMCID: PMC2396755

Takada, A., H. Ebihara, H. Feldmann, T. W. Geisbert, and Y. Kawaoka.  2007. Epitopes required for antibody-dependent enhancement of Ebola virus infection.  J. Infect. Dis. 196 Suppl 2:S347-356.  PMID:  17940966

Takada, A., H. Ebihara, S. Jones, H. Feldmann, and Y. Kawaoka. 2007. Protective efficacy of neutralizing antibodies against Ebola virus infection. Vaccine. 25:993-999.  PMID:  17055127

Urata, S., T. Noda, Y. Kawaoka, S. Morikawa, H. Yokosawa, J. Yasuda. 2007. Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP.  J. Virol. 81:4895-4899. PMID:  17301151 PMCID: PMC1900181

Vasilakis, N., E. J. Shell, E. B. Fokam, P. W. Mason, K. A. Hanley, D. M. Estes, and S. C. Weaver. 2007. Potential of ancestral sylvatic dengue-2 viruses to re-emerge. Virology. 358:402-412. PMID: 17014880

Watanabe, S., T. Noda, P. Halfmann, L. Jasenosky, and Y. Kawaoka. 2007. Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome.  J. Infect. Dis. 196:S284-290.  PMID:  17940962

Yamayoshi S, Kawaoka Y. 2007. Mapping of a region of Ebola virus VP40 that is important in the production of virus-like particles.  J. Infect. Dis. 196:S291-295.  PMID:  17940963

2006 Publications

Adkins, J. N., h. M. Mottaz, A. D. Norbeck, J. K. Gustin, J. Rue, T. R. Clauss, S. O. Purvine, K. D. Rodland, F. Heffron, and R. D. Smith. 2006. Analysis of the Salmonella typhimurium proteome through environmental response toward infectious conditions.  Mol. Cell. Proteomics. 5:1450-1461. PMID: 16684765

Baas, T., C. R. Baskin, D. L. Diamond, A. Garcia-Sastre, H. Bielefeldt-Ohmann, T. M. Tumpey, M. J. Thomas, V. S. Carter, T. H. Teal, N. Van Hoeven, S. C. Proll, J. M. Jacobs, Z. R. Caldwell, M. A. Gritsenko, R. R. Hukkanen, D. G. Camp, R. D. Smith, and M. G. Katze. 2006. Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics. J. Virol. 80:10813-10828. PMID: 16928763 PMCID: PMC1641753

Baas, T., J. Taubenberger, P. Y. Chong, P. Chui, and M. G. Katze. 2006. SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues. J. Interferon Cytokine Res. 26:309-317.  PMID: 16689659

Bär S, A. Takada, Y. Kawaoka, and M. Alizon. 2006. Detection of cell-cell fusion mediated by the Ebola virus glycoproteins.  Running title: Ebola virus GP-mediated fusion.  J. Virol. 80:2815-2822. PMID:  16501090 PMCID: PMC1395460

Cardenas, W, Y.-M. Loo, M. Gale, Jr., A. L. Hartman, C. R. Kimberlin, L.-M. Sobrido, E. O. Saphire, and C. Basier. 2006. The Ebola virus VP35 protein binds double stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.  J. Virol. 80:5168-5178. PMID: 16698997 PMCID: PMC1472134

Chen, H., Y. Li, Z. Li, J. Shi, K. Shinya, G. Deng, Q. Qi, G. Tian, S. Fan, H. Zhao, Y. Sun, and Y. Kawaoka. 2006. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J. Virol. 80:5976-5983.  PMID:  16731936 PMCID: PMC1472608

Co, D.O., L. H. Hogan, J. Karman, E. Heninger, S. Vang, K. Wells, Y. Kawaoka, and M. Sandor. 2006. Interactions between T cells responding to concurrent mycobacterial and influenza infections. J. Immunol. 177:8456-8465.  PMID: 17142743

Deming, D., T. Sheahan, M. Heise, B. Yount, N. Davis, A. Sims, M. Suthar, J. Harkema, A. Whitmore, R. Pickles, A. West, E. Donaldson, K. Curtis, R. Johnston, and R. Baric. 2006. Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants. PLoS Med. 3:e525. PMID: 17194199 PMCID: PMC1716185

Ebihara, H., A. Takada, D. Kobasa, S. Jones, G. Neumann, S. Theriault, M. Bray, H. Feldmann, and Y. Kawaoka. 2006. Molecular determinants of Ebola virus virulence in mice. PLoS Pathog. 2(7):e73.  PMID: 16848640 PMCID: PMC1513261

Fayzulin, R., F. Scholle, O. Petrakova, I. Frolov, and P. W. Mason. 2006. Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines. Virology. 351:196-209. PMID: 16647099

Filone, C. M., M. Heise, R. W. Doms, and A. Bertolotti-Ciarlet. 2006. Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors. Virology. 356:155-164. PMID:  16945399

Fredericksen, B., and M. Gale, Jr. 2006. West Nile virus evades activation of interferon regulatory 3 through RIG-I-dependent and independent pathways without antagonizing host defense signaling.  J. Virol. 80:2913-2923. PMID:  16501100 PMCID: PMC1395472

Gu, B., S. Ouzunov, L. Wang, P. Mason, N. Bourne, A. Cuconati, and T. M. Block. 2006. Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen. Antiviral. Res. 70:39-50. PMID: 16724398

Hatakeyama, S., and Y. Kawaoka. 2006. The molecular basis of resistance to anti-influenza drugs. Nippon Rinsho. 64:1845-1852. PMID:  17037359

Hixson, K. K., J. N. Adkins, S. E. Baker, R. J. Moore, B. A. Chromy, R. D. Smith, S. L. McCutchen-Maloney, and M. S. Lipton. 2006. Biomarker candidate identification in Yersinia pestis using organism-wide semiquantitative proteomics. J. Proteome Res. 5:3008-3017. PMID: 17081052

Horimoto, T., and Y. Kawaoka. 2006. Strategies for developing vaccines against H5N1 influenza A viruses. Trends Mol. Med. 12:506-514. PMID:  17011235

Horimoto, T., A. Takada, K. Fujii, H. Goto, M. Hatta, S. Watanabe, K. Iwatsuki-Horimoto, M. Ito, Y. Tagawa-Sakai, S. Yamada, H. Ito, T. Ito, M. Imai, S. Itamura, T. Odagiri, M. Tashiro, W. Lim, Y. Guan, M. Peiris, and Y. Kawaoka.  2006. The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate. Vaccine. 24:3669-3676. PMID: 16378663

Iwatsuki-Horimoto, K., T. Horimoto, T. Noda, M. Kiso, J. Maeda, S. Watanabe, Y. Muramoto, K. Fujii, and Y. Kawaoka. 2006. The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. J. Virol. 80:5233-5240.  PMID:  16699003 PMCID: PMC1472145

Kash, J. C., A. G. Goodman, M. J. Korth, and M. G. Katze. 2006. Hijacking of the host-cell response and translational control during influenza virus infection. Virus Res. 119:111-120.  PMID: 16630668

Kash, J. C., E. Mühlberger, V. Carter, O. Grosch, O. Perwitasari, S. C. Proll, M. J. Thomas, F. Weber, H.-D. Klenk, and M. G. Katze. 2006. Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type 1 interferon response is associated with enhanced virulence. J. Virol. 80:3009-3020. PMID: 16501110 PMCID: PMC1395418

Kash, J. C., T. M. Tumpey, S. C. Proll, V. Carter, O. Perwitasari, M. J. Thomas, C. F. Basler, P. Palese, J. K. Taubenberger, A. Garcia-Sastre, D. E. Swayne, and M. G. Katze.2006. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578-581.  PMID: 17006449 PMCID: PMC2615558

Keller, B. C., B. L. Fredericksen, M. A. Samuel, R. E. Mock, P. W. Mason, M. S. Diamond, and M. Gale, Jr. 2006. Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J. Virol. 80:9424-9434. PMID: 6973548 PMCID: PMC1951458

Korth, M. J., J. C. Kash, C. R. Baskin, and M. G. Katze. 2006. Insights into influenza virus-host interactions through global gene expression profiling: cell culture systems to animal models, p. 341-360. In: Influenza virology: current topics. Y. Kawaoka (ed.), Horizon Scientific Press, Wymondham, U.K.

Langland, J. O., J. C. Kash, V. Carter, M. J. Thomas, M. G. Katze, and B. L. Jacobs. 2006. Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J. Virol. 80:10083-10095. PMID: 17005686 PMCID: PMC1617298

Mason, P. W., A. V. Shustov, and I. Frolov. 2006. Production and characterization of vaccines based on flaviviruses defective in replication. Virology 351:432-443.  PMID: 16712897 PMCID: PMC2430078

Mibayashi, M., L. Marinez-Sobrido, Y.-M. Loo, W. B. Cardenas, C. Basler, M. Gale, Jr., and A. Garcia-Sastre. 2006. Inhibition of retinoic acid-inducible gene-I-mediated induction of interferon-b by the NS1 protein of influenza virus.  J. Virol. 81:514-524. PMID:  17079289 PMCID: PMC1797471

Morrison, T. E., A. C. Whitmore, R. S. Shabman, B. A. Lidbury, S. Mahalingam, and M. T. Heise. 2006. Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis. J. Virol. 80:737-749. PMID: 16378976 PMCID: PMC1346871

Muramoto, Y., T. Q. Le, L. S. Phuong, T. Nguyen, T. H. Nguyen, Y. Sakai-Tagawa, T. Horimoto, H. Kida, and Y. Kawaoka. 2006. Pathogenicity of H5N1 influenza A viruses isolated in Vietnam between late 2003 and 2005. J. Vet. Med. Sci. 68:735-737.  PMID:  16891788

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