Research Projects
(for detailed project description please click on the Project Number)

Theme 1

Identify age-related immune system defects to develop new vaccines and supplemental therapies to enhance protection of individuals to NIAID Category A-C pathogens. (Research Projects 001, 002 & 003)

RP001   CD8 Responses in Situations of Limited T-cell Repertoire
              Michael Bevan, Ph.D., University of Washington

RP002   Broad-Based Intervention to Improve T-cell Protection in Normal and Vulnerable Populations
Janko Nikolich-Zugich, M.D., Ph.D., University of Arizona
Scott Wong, Ph.D., Oregon Health & Science University

Theme 2

Use systems genetic, chemical and proteomics approaches to identify therapeutic targets for biodefense and emerging diseases (Research Projects 004, 005, 006, 007, 008  & 009).

RP004   Systems Pathogenomics of  Severe Respiratory Virus Infection
              Ralph Baric, Ph.D., University of North Carolina
RP005   Mechanisms of Ebola Virus Pathogenesis and Innate and Adaptive Immunity
              Yoshihiro Kawaoka, D.V.M., Ph.D., University of Wisconsin
              Michael Gale, Jr., Ph.D., University of Washington
              Ilhem Messaoudi, Ph.D., Oregon Health & Science University
RP006   Systems Biology Approaches to Viral Pathogenesis and Immunity
              Michael G. Katze, Ph.D., University of Washington
RP007   Pro- and Anti-viral Host Pathways in Flavivirus Pathogenesis
              Michael Gale, Jr., Ph.D., University of Washington
              Michael Diamond, Ph.D., Washington University St. Louis
RP008   Kinase Networks Controlling Flavivirus Replication
              Klaus Frueh, Ph.D., Oregon Health & Science University
              Jay A. Nelson, Ph.D., Oregon Health & Science University
              Hakim Djaballah, Ph.D., Memorial Sloan Kettering Cancer Center
RP010   Systems-based Analysis of Flaviviral Host Restriction
              Sumit Chanda, Ph.D., Sanford-Burnham Medical Research Institute
              Nevan Krogan, Pn.D., University of California San Francisco
RP011    Identifying Factors Limiting CHIKV Disease by Global Transcriptional Profiling
              Kate D. Ryman, Ph.D., University of Pittsburgh
              William Klimstra, Ph.D., University of Pittsburgh
RP012   The Burden of Chikungunya and Dengue Infection in Kenya
              Angelle Desiree LaBeaud, M.D., Children’s Hospital & Research Center at Oakland
RP013   Strategies to Prevent and Treat EV71 Infection
              Denise A. Galloway, Ph.D., Fred Hutchinson Cancer Research Center

Supplement  Systems-Level Views of Viral Virulence Modulation via Monoclonal Antibody
              Jay A. Nelson, Ph.D., Oregon Health & Science University Treatment”
              Michael G. Katze, Ph.D., University of Washington