Jay A. Nelson, Ph.D.

Jay A. Nelson, Ph.D is a senior molecular virologist with over 166 papers and reviews on a variety of topics including herpesviruses, retroviruses, and flaviviruses. He has received Faculty Awards from the American Cancer Society, is a Fellow of the American Academy of Microbiology, and is an Editor for Journal of Virology and Associate Editor for PLOS Pathogens. The primary focus of Dr. Nelson’s research over the years has centered on the molecular pathogenesis of cytomegalovirus (CMV). Some of the seminal observations from his laboratory include the identification of the latent reservoir of the virus as a myeloid lineage cell, the identification and characterization of a viral G-coupled receptor as a factor in the acceleration of vascular disease, the characterization of virally encoded microRNAs (as well as the CMV genes regulated by these RNA species), the use of CMV as an effective vaccine platform, and more recently, the generation of a humanized mouse to study molecular aspects of human CMV latency and reactivation. Over the past 5 years, Dr. Nelson’s group in collaboration with Drs Klaus Früh, Janko Nikolich-Zugich, and Ashlee Moses, has established a program to elucidate host-pathogen interactions with West Nile virus. These studies included the use of functional genomic approaches to determine that cYes, a cellular Src kinase, is an important regulator of flavivirus maturation and an enzyme hijacked by the virus resulting in tight junction malfunction. These studies form the basis of Project 4.2. The second aspect of Dr. Nelson’s flavivirus program is his work with Dr. Nikolich-Zugich to elucidate mechanisms of West Nile virus disease in the aged immunosenescent population

Dr. Nelson is also the founder and Director of the Vaccine and Gene Therapy Institute (VGTI; described later in this section). The founding goal of the VGTI was to assemble a multidisciplinary team of scientists to respond to increasingly serious viral disease threats including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases, and infectious diseases of the elderly. The development of vaccines and novel immune and gene therapeutic approaches to these diseases are the major priorities of the faculty. Recently, the VGTI signed a contract with the state of Florida to expand the institute to Port St. Lucie. Dr. Rafick Sékaly, a top-flight immunologist, was recruited as Co-Director of VGTI Florida. Dr. Nelson will be the Director of both VGTI Oregon and Florida, with Drs Picker and Sékaly the Co-Directors at the respective institutes with responsibilities for directing their scientific programs. Dr. Sékaly will also have an appointment at VGTI Oregon and the ONPRC. Dr. Nelson’s laboratory will remain at VGTI Oregon, where he will direct the PNWRCE.


EDUCATION

California State University, Hayward, CA, B.S., Biological Sciences, 1975.
Oregon State University, Corvallis, OR, Ph.D., Microbiology, 1980.
Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA, 1980-1984.

PROFESSIONAL RECORD

Teaching Assistant, Department of Microbiology, Oregon State University, Corvallis, OR, 

Predoctoral Trainee, National Institutes of Health, Department of Microbiology, Oregon State University with Dr. Jo-Ann Leong, 1975-1980

Research Associate, Tumor Biology Program at Fred Hutchinson Cancer Research Center with Drs. James K. McDougall and Denise A. Galloway, 1980-1981.

Postdoctoral Fellow of the National Institutes of Health awarded from the National Cancer Institute, 1981-1984.

Assistant Member, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, 1984 -1989.

Associate Member, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, 1989-1992.

Adjunct Associate Professor, Department of Pathology, University of California at San Diego, CA, 1990-1992.

Professor, Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, 1992-present

Head of Pathobiology and Immunology Division, Oregon Regional Primate Research Center, Beaverton, OR, 1998 to 2000

Director of Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland, OR, 1998 to present

Director of Vaccine and Gene Therapy Institute, Florida, Port St. Lucie, FL  2008 to Present

Director of the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases 2009 to Present

HONORS

American Cancer Society Junior Faculty Award, 1984-1987
American Cancer Society Faculty Award, 1988-1992
Robert Honess Lecturer, American Society of Virology, 1998
Fellow of the American Academy of Microbiology

MEMBERSHIPS

American Society for Microbiology
American Society for Virology
American Association for the Advancement of Science

EDITORIAL SERVICES

Editor Journal of Virology, 2002-present
Editorial Board for Journal of Virology, 1992-2002
Editorial Board for Virology, 1994-present
Editorial Board for Viral Immunology, 2000-present
Editorial Board for Journal of NeuroVirology, 1994- present
Editor for AIDS Targeted Information, 1992-1998
Editorial Board for Science's NeuroAIDS Website
Reviewer for:   Cell
                           Immunity
                           PNAS
                           Science
                           Nature
                           Nature Medicine
                           Nature Immunology
                           Nature Cell Biology
                           Journal of Infectious Disease
                           American Journal of Pathology
                           Molecular Cellular Biology
                           Journal of Clinical Investigations
                           AIDS
                           Journal of Cell Biology
                           Circulation Research

PEER REVIEW COMMITTEES

Adhoc Member of Experimental Virology Study Section NIH, 1988
Adhoc Reviewer for NIMH, 1988
Adhoc Reviewer for NCI, 1988
Permanent Member of Universitywide California Task Force on AIDS, 1988 to 1992
Scientific Advisory Board for AMFAR, 1990 to present
Scientific Advisory Board for the Pediatric AIDS Foundation, 1996 to present
Member of Virology and Molecular Biology Study Section, American Cancer Society, 1994
Member of the Oregon Medical Research Foundation Review Committee, 1992 – 1997
Permanent Member of Virology Study Section NIH, 2000 to 2004
Permanent Member of American Cancer Society Molecular Biology Study Section 2004-
Permanent Member Virology Study Section B 2005-present

OHSU INSTITUTIONAL COMMITTEES

Immunologist Search Committee
Primate Center Director Search Committee
Molecular Microbiology and Immunology Department Seminar Coordinator
OHSU Measure 5 Budget Committee
Cancer Center Chair Search Committee
Ad Hoc Basic Science Reorganization Committee
Primate Center Programming Committee
OHSU Promotion and Tenure Committee
Interim Member of the Research Council
OHSU Research Advisory Committee

INVITED SPEAKER

(2011)
National Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research, Denver, April

(2010)
NCRR Biomedical Technology Resource Center Advisory Committee, Richland, Washington February
National Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research, Las Vegas, April
Invited Speaker Department of Molecular Genetics and Micobiology, University of Texas, Austin May
Boehringer Ingelheim Advisory Board Meeting, Boston, May
Invited Speaker Novartis Institute for Biomedical Research Seminar Boston, June
Invited Speaker International Herpesvirus Workshop, Salt Lake City, July
Invited Speaker VGTI Florida Retreat, Portland, August
Host, Regional Center of Excellence Dengue Virus Workshop, Portland, August
Pacific Northwest Regional Center of Excellence Annual Meeting, Portland, September
National Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research Network Meeting, Washington, DC October

(2009)
MRC Multidisciplinary Centre of Excellence for Virology Research, London, United Kingdom, February
Invited Speaker University of Turin, Turin, Italy, February
NCRR Biomedical Technology Resource Center Advisory Committee, Richland, Washington, March
National Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research, Washington, DC May
Special Populations Meeting, Philadelphia, Pennsylvania September
Novartis Dengue Meeting, Manila, Philippines  September
Directorship Search Committee, Glasgow Centre for Virus Research September, October
Invited Speaker 13th International Conference of Immunobiology and Prophylaxis of Human Herpesvirus Infections, Orvieto, Italy

(2006)

Invited Speaker University of Pittsburgh, May
Invited Speaker International Herpesvirus Workshop, University of Washington, July

(2005)

Invited Speaker Princeton University, Princeton NJ March
Invited Speaker International Cytomegalovirus Workshop, Williamsburg VA, April
Invited Speaker American Society of Virology, Philadelphia, PA, June
Invited Speaker International Herpesvirus Workshop, Turku, Finland,  July
Invited Speaker St Louis University, St Louis Mo December

(2004)

Invited Speaker University of Turku, Finland
Invited Speaker Functional Genomics and Bioinformatics Approaches to Disease, Portland OR October,
Invited Speaker University of California at Los Angeles, Los Angeles CA, November,

(2003)

Invited Speaker The Scripps Research Institute
Invited Speaker Harvard Medical School Department of Microbiology, Boston MA April, 2003
Invited Speaker 9th International Cytomegalovirus Workshop Maastricht Netherlands May 2003
Invited Speaker NHLBI Meeting on Infectious Origins of Atherosclerosis, Washington DC May 2003
Invited Speaker In Search of Infectious Triggers of Type 1 Diabetes TEDDY workshop Washington DC August 2003
Invited Speaker 3rd International congress on Vascular Dementia, Prague CZ Nov 2003
Invited Speaker University of North Carolina at Chapel Hill, Nov 2003

(2002)

Invited Speaker University of Texas Southwestern Medical School Department of Microbiology, Dallas, TX February 2002
Invited Speaker LSU Medical School Department of Microbiology, Shreveport LA April 2002
Invited Speaker Meeting on Infection and Atherosclerosis Washington DC April 2002
Invited Speaker FASEB Summer Conferences Microbial Pathogenesis: Mechanisms of Infectious Diseases Keystone CO August 2002
Invited Speaker Ph. Laudat European Conferences “Brain Endothelium and Pathologies Aix-les-Bains France October 2002
Invited Speaker American Heart Association Meeting Chicago, IL November 2002

(2001)

Invited Speaker University of California at Irvine Department of Microbiology, Irvine, CA April 2001
Invited Speaker University of Colorado Department of Microbiology, Denver, CO, February 2001
Invited Speaker International Immunology Meeting, Stockholm, Sweden July 2001
Invited Speaker University of Nevada at Reno January 2001

(2000)

Co-Organizer of the 25th Annual International Herpesvirus Workshop, Portland, OR, August, 2000
Invited Speaker University of Mass, March 2000
Invited Speaker Nobel Lecture Series, Stockholm, Sweden, March 2000
Invited Speaker ICCAC, Toronto, Canada, September 2000
Invited Speaker Cytomegalovirus Vaccine Meeting, CDC Atlanta, GA, October 2000

(1999)

Invited speaker Wyeth Ayerst, March 1999
Invited speaker Keystone Meeting on Viral and Bacterial Diseases of the CNS, Taos NM, March 1999
Invited speaker University of California Irvine, April 1999
Invited speaker Herpesvirus Associated Causes and Disease in the Immune Suppressed Colloquium,Chicago IL., April 1999
Co-Organizer of ASM Cell Biology/Pathogenesis Meeting, Portland, OR, April, 1999
Invited speaker Gordon Conference on Viral Diseases of the CNS, June 1999
Invited speaker 24th International Herpesvirus Workshop, Boston MA, July 1999
Invited Speaker OSU Microbiology Department’s Centennial Celebration August 1999

(1998)

Participant in the AMFAR Think Tank on HIV Reservoirs, Boston, MA, March 1998
Invited Plenary Session Speaker American Society of Virology, Vancouver, BC, July 1998
Invited speaker at International Transplantation Meeting, Montreal, Canada, July 1998
Invited speaker NIH Workshop on the Blood Brain Barrier and HIV disease, September 1998
Invited speaker CDC Workshop on the Potential Role of Infections in Cardiovascular Disease, September 1998
Invited speaker Glaxo-Welcome, September 1998
Invited speaker Department of Microbiology, University of Iowa, November 1998

(1997)

Invited speaker 6th International CMV Conference, Pensacola, FL,  March 5-9, 1997
Invited speaker 10th International Conference on Antiviral Research, Atlanta, GA, April 6-11, 1997
Invited speaker at Keystone Symposia on AIDS Pathogenesis, Keystone, Colorado, April 8-13, 1997
Invited speaker at The Scripps Research Institute, La Jolla, CA, May 15, 1997
Invited speaker at Stanford University, Stanford, California, May 29, 1997
Chair of Session on Latency, 22nd International Herpesvirus Workshop, August 2-8, 1997.
 Invited speaker at the 8th International Conference of Immunobiology and Prophylaxis of Human Herpesvirus Infections, Mishima, Kanagawa, Japan, October 5-8, 1997
Invited speaker for the Tubingen Virology Institute Symposia, Tubingen, Germany, October 23-25, 1997

(1996)

Invited speaker IHMF Workshop, Madrid, Spain March 28-30, 1996
Keynote speaker ASM Annual Meeting, New Orleans, La. May 19-24, 1996
Keynote speaker 2nd International Valtrex Symposia, Montreux, Switzerland June 28-29, 1996.
Invited participant at HIV in the Brain: Pathology and Neurobehavioral Consequences Workshop sponsored by the Office on AIDS, National Institute of Mental Health in Washington, DC, September 4-6, 1996
Invited speaker 14th Annual Symposium on Nonhuman Primate Models for AIDS, Portland, OR October 23-26,1996
Rapporteur 4th Annual Meeting Of the IHMF, Barcelona, Spain November 9-10, 1996

(1995)

Invited speaker Department of Microbiology, University of Washington, Seattle, WA, April, 1995
Invited speaker FASEB Meeting, Atlanta, GA, April, 1995
Invited speaker The Scripps Research Institute, La Jolla, CA, April, 1995
Lectures in Immunology, Reed College, Portland, OR
Keynote speaker 5th International Cytomegalovirus Workshop in Stockholm, May, 1995
Invited speaker 7th International Conference on Immunology and Prophylaxis of Human Herpesvirus Infections, Tampa, FL, October, 1995
Co-organizer of the 2nd Annual Westcoast Retrovirus Meeting, Newport, CA  1995

(1994)

Invited speaker at NOVUM Lectures in Cell and Molecular Biology, Stockholm, April 1994
Invited speaker at 19th International Herpesvirus Workshop in Vancouver, BC, July, 1994
Marquam Hill Lecturer, OHSU, September, 1994
Invited speaker at West Coast Retrovirus meeting in Newport Beach, CA, October, 1994

(1993)

Invited speaker at University of North Carolina at Chapel Hill, North Carolina, January 1993
Invited speaker Keystone Symposia "Molecular Immunology of Virus", February 1993
Invited speaker Keystone Symposia "Frontiers in HIV Pathogenesis", March 1993
Invited speaker at 4th International Cytomegalovirus Workshop in Paris, France, April 1993
Invited speaker at IXth International Conference on AIDS in Berlin, Germany, June 1993
Invited speaker at NIH Conference on Neuro-AIDS in Portland, ME, August 1993
Invited speaker at Technical Advances in AIDS Research in Human Nervous Systems   Conference in Washington D.C., October 1993

CONSULTATION

Federal
FDA Panel on the evaluation of a Live CMV Vaccine November, 1999

ACADEMIC

Sexually Transmitted Disease Center Grant (Dr. King Holmes, University of Washington, Seattle, WA)

Molecular Mechanisms of AIDS Dementia Center Grant - NIMH P50 MH47680 (Dr. Floyd Bloom, The Scripps Research Institute, La Jolla, CA)

AIDS Dementia Core Grant (Dr. Howard Fox The Scripps Research Institute, La Jolla, CA)

Advisory Board Member for the Pacific Northwest National Laboratory Proteomics Group

CORPORATE 

Glaxo Welcome
Ortho Diagnostics Corp
ISIS Corp
Pharmacia Corp
ICOS Corp                                   
Virogenomics
O’Connor, Cohn, Dillon, & Barr Law Corp.
Johnson & Johnson Corp

PATENT

US Patent # US 6,225,048 B1
Dendritic Marker-Expressing Macrophage Cultures and Methods for Reactivating Latent HCMV
US Patent No. 6,420,121
Prevention of Cell Migration Initiation with US28 Receptor Agonists
US Patent Application 10/564,369 for Methods of Treatment and Diagnosis Using Modulators of Virus-Induced Cellular Gene Sequences
Pending:
“ Inhibition of Flavivirus replication by inhibitors of Src-Family kinases”

EDUCATIONAL, ADMINISTRATIVE AND TEACHING DUTIES

        
Teaching 1992 to Present
         MBIM 608 Advanced Virology - Course Organizer
         MBIM 611 Microbial Pathogenesis
         MBIM 605Pathogenesis Journal Club
         MSCI 614 Biological Basis of Disease
Committees
         Promotion and Tenure Committee
         MD/Ph.D. Admission Committee
         Graduate Qualifying Committee
         Faculty Senate
Established the OHSU Transgenic and Gene Knockout Mouse Facility
Established the OHSU Molecular Biology Core Facility
Established the OHSU Confocal Microscopy Facility
Established the OHSU Vaccine & Gene Therapy Institute

BIBLIOGRAPHY

Peer Reviewed Articles
1. Nelson, J.A., J.C. Leong and J. Levy.  Particles with characteristics of retroviruses in human placentas.  Proc. Natl. Acad. Sci. 75:6263-6267, 1978.

2.Nelson, J.A., J.A. Levy and J.C. Leong.  Human placentas contain a specific inhibitor of RNA-directed DNA polymerase.  Proc. Natl. Acad. Sci. 78:1670-1674, 1981.

3. Nelson, J.A., B. Fleckenstein, D.A. Galloway and J.K. McDougall.  Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD 169.  J. Virol. 43:83-91, 1982.

4. Myerson, D., R.C. Hackman, J.A. Nelson, D.C. Ward and J.K. McDougall.  Widespread presence of histologically occult cytomegalovirus.  Human Pathology 15:430-439, 1984.

5. Nelson, J.A., B. Fleckenstein, G. Jahn, D.A. Galloway and J.K. McDougall.  Structure of the transforming region of human cytomegalovirus strain AD169.  J. Virol. 49:109-115, 1984.

6. Jahn, G., E. Knust, H. Schmolla, T. Sarre, J.A. Nelson, J.K. McDougall and B. Fleckenstein.  Predominant immediate-early transcripts of human cytomegalovirus AD 169.  J. Virol. 49:363-370, 1984.

7. McDougall, J.K., J.A. Nelson, D. Myerson, A.M. Beckman and D.A. Galloway.  HSV, CMV and HPV in human neoplasia.  33rd Symposium on Biology of Skin.  J. Invest. Derm. 83:72s-76s, 1984.

8. Leong, J.C., J.A. Nelson and J.A. Levy.  Optimal conditions for detection of reverse transcriptase activity in human placentas.  Acta Biochem. Biophys.  782:441-445, 1984.

9. Galloway, D.A., J.A. Nelson and J.K. McDougall.  Small fragments of herpes-virus DNA with transforming activity contain IS-like structures.  Proc. Natl. Acad. Sci.  USA 81:4736-4740, 1984.

10. Wiley, C.A., R.D. Schrier, F.J. Denaro, J.A. Nelson, P.W. Lampert  and M.B.A. Oldstone.  Localization within the CNS of cytomegalovirus proteins and genome during fulminant infection in an AIDS patient.  J. Neuropath. Exp. Neurol.  45:127-139, 1986.

11. Nelson, J.A. and M. Groudine.  Transcriptional regulation of the HCMV major immediate-early gene is associated with induction of DNasel hypersensitive sites.  Mol. Cell. Biol.  6:452-461, 1986.

12. Schrier, R.D., J.A. Nelson and M.B.A. Oldstone.  Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection.  Science 230:1048-1051, 1985.

13. Wiley, C.A., R.D. Schrier, J.A. Nelson, P.W. Lampert and M.B.A. Oldstone.  Cellular localization of human immunodeficiency virus infection with the brains of acquired immune deficiency syndrome patients.  Proc. Natl. Acad. Sci.  USA 83:7089-7093, 1986.

14. Levy, J.A., L. Evans, C. Cheng-Mayer, L-Z. Pan, A. Lane, C. Staben, D. Dina, D. Wiley and J.A. Nelson.  Biologic and molecular properties of the AIDS-associated retrovirus that affect antiviral therapy.  Ann. Institut Pasteur 139:101-111, 1987.

15. Nelson, J.A., C. Reynolds-Kohler and B.A. Smith.  Negative and positive regulation by a short segment in the 5'-flanking region of the human cytomegalovirus major immediate-early gene.  Mol Cell. Biol.  7:4125-4129, 1987.

16. Kohwi-Shigematsu, T. and J.A. Nelson.  The chemical carcinogen, chloraacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo.  Mol. Carcin. 1:20-25, 1988.

17. Gnann, J.W., P.L. Schwimmbeck, J.A. Nelson, A.B. Truax and M.B.A. Oldstone.  Diagnosis of AIDS by using a 12 amino acid peptide representing an immunodominant epitope of the human immunodeficiency virus.  J. Infect. Dis. 156:261-267, 1987.

18. Fujinami, R.S., J.A. Nelson, L. Walker and M.B.A. Oldstone.  Sequence homology and immunologic cross-reactivity of human cytomegalovirus with LA DR chain:  A means for graft rejection and immunosuppression.  J. Virol. 62:100-105, 1988.

19. Gnann, J.W., J.A. Nelson and M.B.A. Oldstone.  Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus.  J. Virol. 61:2639-2641, 1987.

20. Gnann, J.W., J.B. McCormick, S. Mitchell, J.A. Nelson and M.B.A. Oldstone.  Synthetic peptide immunassay distinguishes human immunodeficiency virus type 1 and type 2 infections.  Science 237:1346-1349, 1987.

21. Nelson, J.A., C. Reynolds-Kohler, M.B.A. Oldstone and C. Wiley.  HIV and HCMV co-infect brain cells in patients with AIDS.  Virology 165:286-290, 1988.

22. Gnann, J.W., J. Ahlmen, C. Svalander, L. Olding, M.B.A. Oldstone and J.A. Nelson.  Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus.  Am. J. Pathol. 132:239-247, 1988.

23. Wiley, C.A., M. Grafe, C. Kennedy and J.A. Nelson.  HIV  and JC virus in AIDS patients with progressive multifocal leukoencephalopathy.  Acta Neurol. 76:338-346, 1988.

24. Nelson, J.A., C.A. Wiley, C. Reynolds-Kohler, W. Margaretten, C.E. Reese and J.A. Levy.  Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms.  Lancet i:259-262, 1988.

25. Wiley, C.A. and J.A. Nelson.  Role of human immunodeficiency virus and cytomegalovirus in AIDS encephalitis.  Am. J. Pathol.  133:73-81, 1988.

26. Schrier, R.D., J.W. Gnann, A.J. Langlois, K. Shriver, J.A. Nelson and M.B.A. Oldstone.  B and T lymphocyte responses to an immunodominant epitope of human immunodeficiency virus.  J. Virol. 62:2531-2536, 1988.

27. Lubon, H., P. Ghazal, L. Hennighausen, C. Reynolds-Kohler, C. Lockshin and J.A. Nelson.  Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene.  Mol. Cell. Biol. 9:1342-1345, 1989.

28. Schrier, R.D., J.W. Gnann, Jr., R. Landes, C. Lockshin, D. Richman, A. McCutchan, C. Kennedy, M.B.A. Oldstone and J.A. Nelson.  T cell recognition of HIV synthetic peptides in a natural infection.  J. Immunol. 142:1166-1176, 1989.

29. Wiley, C.A. and J.A. Nelson.  Human immunodeficiency virus:  Infection of the nervous system.  Curr. Topics Microbiol. Immunol.  160:157-172, 1990.

30. Wiley, C.A., A.L. Belman, D.W. Dickson, A. Rubinstein and J.A. Nelson.  Human immuno-deficiency virus in the brains of children with AIDS.  Clin. Neuropath.  9:1-6, 1990.

31. Schiodt, M., D. Greenspan, T.E. Daniels, J. A. Nelson, P.J. Leggott, D.W. Wara and J.S. Greenspan.  Parotid gland enlargement and xerostomia associated with labial sialadenitis in HIV-infected patients.  J. Autoimmun.  2:415-425, 1989.

32. Stenberg, R.M., A.S. Depto, J. Fortney and J.A. Nelson.  Regulated expression of early and late RNA and protein from the human cytomegalovirus immediate early gene region.  J. Virol.  63:2699-2708, 1989.

33 Chang, C-P., D.H. Vesole, J. A. Nelson, M.B.A. Oldstone and M.F. Stinski.  Identification and expression of a human cytomegalovirus early glycoprotein.  J. Virol.  63:3330-3337, 1989.

34. Levy, J.A., W. Margaretten and J.A. Nelson.  Detection of HIV  in enterochromaffin cells in the rectal mucosa of an AIDS patient.  Amer. J. Gastro.  

35. Schoidt, M., D. Greenspan, J.A. Levy, J.A. Nelson, D. Chernoff, H. Hollander and J.S. Greenspan.  Does HIV cause salivary gland disease?  AIDS 3:819-822, 1989.

36. Lathey, J.L., J.M. Agosti, J.A. Nelson, L. Correy, S.A. Gregory, J.H. Morrissey, T.S. Edgington and M.B.A. Oldstone.  A selective defect in tissue factor mRNA expression in monocytes from AIDS patients.  Clin. Immunol. Immunopathol.  54:1-13, 1990.

37. Lohr, M., J.A. Nelson and M.B.A. Oldstone.  Is herpes simplex virus associated with peptic ulcer disease?  J. Virol. 64:2168-2174, 1990.

38. Ghazal, P., H. Lubon, C. Reynolds-Kohler, L. Hennighausen and J.A. Nelson.  Interactions between cellular regulatory proteins and a unique sequence region in the human cytomegalovirus major immediate-early promoter.  Virology 174:18-25, 1990.

39. Lathey, J.L., C.A. Wiley, M.A. Verity and J.A. Nelson.  Cultured human brain capillary endothelial cells are permissive for infection by human cytomegalovirus.  Virology 176:266-273, 1990.

40. Nelson, J.A., P. Ghazal and C. Wiley.  Role of opportunistic viral infections in AIDS.  AIDS 4:1-10, 1990.

41. Lewis, S.H., C. Reynolds-Kohler and J.A. Nelson.  HIV Type 1 infects trophoblast, villous macrophages and hematologic precursors in eight week embryos.  Lancet i:565-568, 1990.

42. Ghazal, P. and J.A. Nelson.  Transcription factors and viral regulatory proteins as potential mediators of human cytomegalovirus pathogenesis.  Dev. in Virol., , 1992.

43. Lohr, M., J.A. Nelson and M.B.A. Oldstone.  Herpes simplex virus is associated with peptic ulcer disease.  AAP Transactions, C11:213-223, 1989.

44. Stenberg, R.M., J. Fortney, S.W. Barlow, B.P. Magrane, J.A. Nelson and P. Ghazal.  Promoter specific transactivation and repression by human cytomegalovirus immediate early proteins influence common and unique protein domains.  J. Virol. 64:1556-1565, 1990.

45. Ghazal, P. and J.A. Nelson.  Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major IE promoter.  J. Virol. 65:2299-2307, 1991.

46. Schrier, R.D., J.A. McCutchan, J.C. Venable, J.A. Nelson and C.A. Wiley.  T-cell induced expression of HIV in macrophages.  J. Virol. 64:3280-3288, 1990.

47. Pearson, L., J. Garcia, F. Wu, N. Modesti, J. A. Nelson and R. Gaynor.  A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.  Proc. Natl. Acad. Sci. USA 87: 1990.

48. Wiley, C.A., R.D. Schrier, M. Morey, C. Achim, J.C. Venable and J.A. Nelson.  Pathogenesis of HIV encephalitis.  Acta Pathologica Japonica 41:192-195, 1992.

49. Ibanez, C.E., R. Schrier, P. Ghazal, C. Wiley and J.A. Nelson. Human cytomegalovirus productively infects primary differentiated macrophages.  J. Virol., 65:6581-6588, 1992.

50. Ghazal, P., J. Young, E. Giulietti, C. DeMattel, J. Garcia, R. Gaynor, R.M. Stenberg, and J.A. Nelson.  A discrete cis-element in the HIV-LTR mediates synergistic trans-activation by cytomegalovirus immediate-early promoter.  J. Virol., 65:6735-6742, 1992.

51. Baracchini, E., E. Glazer, K. Fish, R. Stenberg, J.A. Nelson and P. Ghazal.  An isoform variant of a CMV immediate-early autorepressor functions as a transcriptional activator.  Virology, 188:518-592, 1992.

52. Spaete, R.R., K. Perot, P.I. Scott, J.A. Nelson, M.F. Stinski, and C. Pachl.  Coexpression of CMV gH with human fibroblast growth factor receptor or the CMV UL115 gene product results in efficient transport of gH to the cell surface.  Virol. 193:001-009, 1993.

53. Moses, A.V., F.E. Bloom, C.D. Pauza and J.A. Nelson.  HIV infection of human brain capillary endothelial cells occurs via a CD4-independent mechanism. PNAS 90:10474-10478, 1993.

54. Jupp, R., O. Flores, J.A. Nelson and P. Ghazal.  The 38kDa subunit of human transcription factor IID binds to the TATA box as a multimer.  J. Biol. Chem.  268:16105-16108, 1993.

55. Ghazal, P. and J.A. Nelson.  Interactions between cytomegalovirus immediate-early proteins and the long terminal repeat of human immunodeficiency virus.  Med. Virol., 3:47-55, 1993.

56. Jupp, R., S. Hoffmann, A. Depto, R.M. Stenberg, P. Ghazal and J.A. Nelson.  Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box.  J. Virol. 67:5595-5604, 1993.

57. Jupp, R., S. Hoffmann, R. Stenberg, J.A. Nelson and P. Ghazal.  Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domain.  J. Virol. 67:7539-7546, 1993.

58. Wu, J., R. Jupp, R. Stenberg, J.A. Nelson and P. Ghazal.  Site-specific inhibition of RNA polymerase II preinitiation complex assembly by human cytomegalovirus IE86 protein. J. Virol. 67:7547-7555, 1993.

59. Achim, C.L., R.M. Nagra, R. Wang, J.A. Nelson and C.A. Wiley.  Detection of cytomegalovirus in cerebrospinal fluid autopsy specimens from AIDS patients.  J. Infect Dis. 169:623-627, 1994.

60. Moses, A.V., C.E. Ibanez, R. Gaynor, P. Ghazal and J.A. Nelson.  Differential role of long terminal repeat control elements for the regulation of basal and tat-mediated transcription of the human immunodeficiency virus in stimulated and unstimulated primary human macrophages.  J. Virol. 68:298-307, 1994.

61. Moses, A.V. and J.A. Nelson.  HIV infection of human brain capillary endothelial cells - Implications for AIDS dementia.  Adv. in Neuroimmunology 4:239-247, 1994.

62. Fish, K.N., A.S. Depto, A.V. Moses, W. Britt and J.A. Nelson.  Growth kinetics of human cytomegalovirus are altered in monocyte derived macrophages. J. Virol. 69:3737-3743, 1995.

63. Watanabe, M., A. Hirano, S. Stenglein, J. A. Nelson, G. Thomas and T.C. Wong.  engineering a1-antitrypsin variant inhibits furin catalyzed activation of the fusion glycoprotein and production of infectious measles virus. J. Virol. 69:3206-3210, 1995.

64. Margolis, M.J., S. Pajovic, M. Wade, R. Jupp, J. A. Nelson and J.C. Azizkhan.  Interaction of the 72 kDa HCMV IE1 gene product with E2F-1 coincides with E2F-dependent activation of DHFR transcription. J. Virol. 69:7759-7767, 1995.

65. Adam, B.-L., C.P. Kohler, T.Y. Jervey, G.L. Wright, Jr., J.A. Nelson and R.M. Stenberg.  The human cytomegalovirus UL98 gene transcription unit overlaps with the pp28 true late gene (UL99) and encodes a 58kd early protein. J. Virol. 69:5304-5310, 1995.

66. Kerry, J.A., A. Sehgal, S.W. Barlow, V.J. Cavanaugh, K. Fish, J.A. Nelson and R.M. Stenberg.  Isolation and characterization of a low-abundance splice variant from the human cytomegalovirus major immediate-early gene region.  J. Virol. 69:3868-3872, 1995.

67. Fish, K.N., S.G. Stenglein, C. Ibanez and J.A. Nelson.  Cytomegalovirus persistence in macrophages and endothelial cells.  Scand. J. of Infec. Dis.99:34-40, 1995.

68. Moses, A.V., S. Williams, M.L. Heneveld, J. Strussenberg, M. Rarick, M. Loveless, G. Bagby and J.A. Nelson.  Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors. Blood 87:919-925, 1996.

69. Moses, A.V., S. G. Stenglein and J.A. Nelson. HIV infection of the brain microvasculature and its contribution to the AIDS dementia complex.  J. Neuro-AIDS, 1:85-95. 1996.

70. Baskar, J., P. Smith, G. Ciment, S. Hoffmann, C. Tucker, A.M. Colberg-Poley, J.A. Nelson and P. Ghazal. 1996. Developmental analysis of the cytomegalovirus enhancer in transgenic animals. J. Virol. 70:3215-3226, 1996.

71. Baskar, J., P. Smith, G. Nilaver, R.A. Jupp, S. Hoffmann, N.J. Peffer, A.M. Colberg-Poley, P. Ghazal and J.A. Nelson.  The enhancer domain of the human cytomegalovirus major immediate early promoter determines tissue specific expression in transgenic mice. J. Virol.70: 3207-3214, 1996.

72.  Fish, K.N., W. Britt and J.A. Nelson.  A novel mechanism for persistence of Human Cytomegalovirus in Macrophages, J. Virol. 70:1855-1862, 1996.

73. Moses, A.V., S.G. Stenglein, J.G. Strussenberg, K. Wehrly, B. Chesebro and J.A. Nelson.  Sequences regulating tropism of HIV-1 for brain capillary endothelial cells map to a unique region on the viral genome. J. Virol. 70:3401-3406, 1996.

74. Jones, T.R., E.J.H.J. Wiertz, L. Sun, K.N. Fish, J.A. Nelson and H.L. Poegh.  Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains, PNAS USA, 93:11327-11333, 1996.

75. Moses, A.V., S.E. Williams, J.G. Strussenberg, M.L. Heneveld, R.A. Ruhl, A.C. Bakke, G.C. Bagby and J.A. Nelson.  HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B cell lymphomas. Nature Medicine 3:1242-1249, 1997.

76. Li, L., J.A. Nelson, and W.J. Britt. Glycoprotein H-related complexes of human cytomegalovirus: identification of a third protein in the gCIII complex. J. Virol 71: 3090-3097. 1997 74.

77. Söderberg-Naucler, C., K.N. Fish and J.A. Nelson.  Reactivation of human cytomegalovirus in a novel dendritic cell phenotype from healthy donors. Cell 91:119-126, 1997.

78. Borrow P., H. Lewicki, X Wei, M.S. Horowitz, N. Peffer, H. Meyers, J. A. Nelson, J.E. Gairin, B.H. Hahn. M.B. Oldstone, and G. M. Shaw. Antiviral pressure exerted by HIV-1 specific cytotoxic T lymphocytes (CTL) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3: 205-211, 1997.

79. Söderberg-Naucler, C., K.N. Fish and J.A. Nelson.  Interferon-g and tumor necrosis factor-a specifically induce  formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines. J. Clin. Inv., 100:3154-3163, 1997.

80. Strelow, L.I., D.A. Watry, H.S. Fox and J.A. Nelson.  Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant.  Neurovirol., 4:269-280, 1998.

81. Mandi, Y., I. Ocsovszki, D. Szabo, S. Nagy, J.A. Nelson and J. Molnar.  Nitric oxide production and MDR expression by human brain endothelial cells.  Anticancer Res. 18:3049-3052, 1998.

82. Fish, K.N., C. Söderberg-Naucler and J.A. Nelson.  Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900.  J. Virol., 72:6657-6664, 1998.

83. Fish, K.N., C. Söderberg-Naucler, S. Stenglein, L. Mills and J.A. Nelson.  HCMV persistantly infects aortic endothelial cells.  J. Virol., 72:5661-5668, 1998.

84. Moses, A., J. A. Nelson and G.C. Bagby.  The influence of human immunodeficiency virus-1 on hematopoiesis.  Blood 91:1479-1495, 1998.

85. Moses, A.V., K.N. Fish, R. Ruhl, P.P. Smith, J.G. Strussenberg, L. Zhu, B. Chandran and J.A. Nelson.  Long-term infection and transformation of dermal endothelial cells by human herpesvirus 8 (HHV8). J. Virol., 73:6892-6902, 1999..

86. Tomazin, R., J. Boname, N.R. Hegde, D.M. Lewinsohn, Y. Altschuler, T.R. Jones, P. Cresswell, J.A. Nelson, S.R. Riddell and D.C. Johnson.  Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Medicine 5:1039-1043, 1999.

87. Jarvis, M.A., C.E. Wang, H.L. Meyers, P.P. Smith, C.L. Corless, G.J. Henderson, J. Vieira, W.J. Britt and J.A. Nelson.  Human cytomegalovirus infection of caco-2 occurs at the basolateral membrane and is differentiation-state dependent J. Virol 73:4552-4560, 1999.

88. Streblow,D.N., C. Soderberg-Naucler, J. Vieira, P. Smith, E. Wakabayashi, F. Ruchti, K. Mattison, Y. Altschuler, and J. A. Nelson. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell 99: 511-520 1999.

89. Dallasta, L.M., L.A. Pisarov, J.E. Esplen, J.V. Werley, A.V. Moses, J.A. Nelson and C.L. Achim.  Blood-brain barrier tight junction disruption in human immunodeficiency virus encephalitis. Amer J. Pathol. 155:1915-1927. 1999

90. Jean, F., L. Thomas, S.S. Molloy, G. Liu, M.A. Jarvis, J.A. Nelson and G. Thomas.  A novel protein-based therapeutic for human cytomegalovirus infection. PNAS 97:2864-2869. 2000

91. Murphy, E.A.,D.N. Streblow, J.A. Nelson, and M.F. Stinski. The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into S phase of permissive cells. J.Virol 74: 7108-7118. 2000

92. Söderberg-Naucler, C., D. Streblow,, K.N. Fish, J Allan-Yorke, and J.A. Nelson. IFN-g dependent reactivation of human cytomegalovirus (HCMV) in allogeneically stimulated macrophages. J. Virol 75(16):7543-54 ,2001.

93. Streblow DN, Orloff SL, and J. A. Nelson. Do pathogens accelerate atherosclerosis  J Nutr. 2001 Oct;131(10):2798S-804S,2001.

94. Streblow DN, Orloff SL, Nelson JA. The HCMV Chermokine Receptor US28 is a potential target in vascular disease. Curr Drug targets Infect Disord 1:151-158, 2001

95. Orloff, S. L., D N. Streblow, C. Soderberg-Naucler, Q. Yin1, C. Kreklywich2,3, C. L.. Corless, P. A. Smith, C. Loomis, L. Mills, J. W. Cook T. De La Melena2, C. A. Bruggeman, J. A. Nelson, and C. R. Wagner. 2001.Elimination of Donor-specific Alloreactivity Prevents Cytomegalovirus-accelerated Chronic Rejection in Rat Small Bowel and Heart Transplants. Transplant Proc;33(1-2):1822-3,  2001.

96. Jarvis, M.A., K.N. Fish, C Söderberg-Naucler+‡ H L. Meyers+, Y. Altshuler,1 G. Thomas and J. A. Nelson. Retrieval of human cytomegalovirus glycoprotein B from the infected cell surface is not required for virus envelopment in permissive astrocytoma cells. J Virol. 76:5147-55, 2002.

97. Moses, A.V., M.A. Jarvis, C. Raggo, Y.C. Bell, R. Ruhl, B.G.M. Luukkonen, D.J. Griffith, C.L. Wait, B.J. Drucker, M.C. Heinrich, J.A. Nelson, and K. Frueh. KSHV-induced upregulation of the c-Kit proto-oncogene, as identified by gene profiling, is essential for the transformation of endothelial cells. J Virol. 16:8383-99, 2002.

98. Strelow, D. Janigro, and J.A. Nelson. Persistent SIV infection of a blood-brain barrier model J Neurovirol4:270-80, 2002.

99. Emmanuelle Le Roy, Wolfgang Faigle, Danièle Clément, David M. Lewinsohn, Daniel Streblow, J .A. Nelson, Sebastian Amigorena, and Jean-Luc Davignon. Control of Human Cytomegalovirus Infection of Antigen Presenting Cells by Anti-IE1 CD4+ T cells. J Immunol. 169(3):1293-301, 2002.

100. Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Frueh K. A functional genomics approach to Kaposi's sarcoma. Ann NY Acad Sci 975:180-91, 2002.

101. Streblow DN, Kreklywich C, Yin Q, De La Melena VT, Corless CL, Smith PA, Brakebill C, Cook JW, Vink C, Bruggeman CA, Nelson JA, Orloff SL. Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants. J Virol 77:2182-2194, 2003.

102. Hsai DA, Mitra SK, Hauck, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KSR, Cheresh DA, Schlaepfer. Differential regulation of cell motility and invasion by FAK. J Cell Biol. 160:753-767, 2003

103. Ilim D, Kovanin B, Yohkura K, Schlaepfer, Tomacevim N, Han Q, Kim J-B, Howerton,K, Baumbusch C, Ogiwara N, Streblow D, Nelson JA, Dazin P, Shino Y, Sasaki K, and Damsky CH. FAK is required for normal fibronectin matrix assembly. J. Cell Science: 117:177-187, 2003

104. Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Schlaephler DA, and Nelson JA. The Human Cytomegalovirus Chemokine Receptor US28 Activates Focal Adhesion Kinase In A Ligand Dependent Manner. J. Biol. Chem 278(50):50456-65, 2003

105. E. Hammarlund1, M. W. Lewis1, S. G. Hansen1, L. I. Strelow1, J. A. Nelson, G. J. Sexton, J. M. Hanifin,  and M. K. Slifka. Duration of antiviral immunity following smallpox vaccination. Nature Medicine 9:1131-1137, 2003.

106. Murphy E., D. Yu, J. Grimwood, J. Schmutz, M. Dickson, M. A. Jarvis, G. Hahn, J.A. Nelson, R. M. Myers, and T Shenk. Coding potential of laboratory and clinical strains of human cytomegalovirus. PNAS no25 100:14976-14981,2003

107. Britt W.J , M. Jarvis, JY Seo, D. Drummond, J. A. Nelson. Rapid engineering of herpesvirus BAC using the RED locus lambda phage: Demonstration that human cytomegalovirus pp28 (UL99) is essential for assembly of infectious virus. J. of Virol 78:539-543, 2004

108. Jarvis, M.A., T. R. Jones, D. D. Drummond, P. S. Smith, W. M. Britt, J. A. Nelson, and C. J. Baldick. Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi Network and efficient Virus replication. J. Virol 78: 285-293, 2004

109. Melnychuk RM, D N. Streblow, P Smith,  A J Hirsch, D. Pancheva, Nelson JA. The human cytomegalovirus encoded G-protein coupled receptor US28 mediates smooth muscle cell migration through Ga12. J. Virol. 78: 8382-9391, 2004

110. Baron M, N. Mirouze, J. A. Nelson, D. N. Streblow,  andJ-L Davignon. Optimization of the CD4+ T cell response to an epitope of the HCMV IE1 protein. J Immun 175:6812-6819, 2005.

111. Henderson W.W., R. Ruhl, P.Lewis, M. Bentley, J.A. Nelson, and A V. Moses. HIV1-Vpu induces expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells. J Virol 78: 4408-20; 2004

112. Henderson W.W., J.R. Smith, J.T. Rosenbaum, E. A. Neuwalt, L Jelinek, J.A. Nelson, and A V. Moses. The growth of AIDS-associated non-Hodgkin lymphoma cells is stimulated by endothelial cells that express HIV-1 tat. Submitted

113. Rue, C., M. Jarvis, A J. Knoche, H. L. Meyers, M Wagner, S. Wong, P. Barry, D. Anders, and J.A. Nelson. A Rhesus cytomegalovirus encoded cyclooxygenase-2 homologue mediates endothelial cell tropism by inhibition of the nitric oxide pathway. J Virol. 78(22):12529-36; 2004

114. Varnum, S. M., D. N. Streblow, M. E. Monroe, P. Smith, K.J. Aubrey, L. Pa_a-Toli, D. Wang, D. G. Camp II, K. Rodland, S. Wiley, W. Britt,T Shenk, R. D. Smith and J. A. Nelson. Identification of proteins in human cytomegalovirus (HCMV) particles: The HCMV proteome. J Virol. 78:10960-6, 2004

115. Streblow D. N., C. N. Kreklywich, P. Smith, J. L. Soule, C. Meyer, M. Yin, K. Vink, J. A. Nelson, S. L. Orloff. Rat cytomegalovirus acceleration of transplant vascular sclerosis and chronic rejection is reduced with mutation of the virally encoded chemokine receptor r33. Amer J. Trans 6:436-442. 2004

116. R. Melnychuk P. Smith, C N. Kreklywich, F. Ruchti, J. Vomaske, L. Hall, Loh L, J. A. Nelson S. L. Orloff, and D. N. Streblow. The mouse cytomegalovirus M33 is necessary and sufficient in virus induced smooth muscle cell migration. J Virol 79:10788-95, 2005

117. Hirsch, A.   G Medigeshi, H Meyers, V De Fillippis, K. Fruh, T Briese, W. I. Lipkin, and J. A. Nelson. The Src Family Kinase c-Yes is Required for Maturation of West Nile Virus Particles. J Virol. 79(18):11943-11951, 2005

118. Grey, F., A. Antoniewicz, E Allen, J. Saugstad,  A.  McShea, J. Carrington, and J. A. Nelson. Identification of human cytomegalovirus encoded miRNAs. J Virol. 79(18):12095-12099, 2005.

119. Hegde, N, C. Dunn, D. M. Lewinsohn, M. A. Jarvis, J. A. Nelson,  and D. C. Johnson Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL. J. Ex. Med.202::1109-1119, 2005.

120. Sylwester, A. W., B. L. Mitchell, J. B. Edgar, C. Taormina, C. Pelte, F. Ruchti, P. R. Sleath, K. H. Grabstein, N. A. Hosken, F. Kern, J. A. Nelson, and L. J. Picker. J. Ex. Med.202: 673-685, 2005.

121. Delmas, S, L. Martin, M. Baron, J.A. Nelson, D. N. Streblow, J. L. Davignon. Optimization of CD4+ T lymphocyte response to human cytomegalovirus nuclear IE1 protein through modifications of both size and cellular localization. J. Immunology 175: 6812-6819.

122. Ryckman,BJ  M Jarvis, D. Drummond, J.A. Nelson, and D. C. Johnson. Human Cytomegaloviruses entry into epithelial and endothelial cells depends on genes UL128 to UL 150 and occurs  by endocytosis and low-pH fusion.  J. Virol 80(2):710-22, 2006.

123. Jarvis M.A., J.A. Borton, A.M. Keech, J. Wong, W. J. Britt, B. E. Magun, and J.A. Nelson. Human cytomegalovirus attenuates interleukin-1 beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation. J Virol 80(11):5588-98, 2006.

124. DeFilippis VR, B Robinson, TM Keck, SG Hansen, J. A. Nelson and  K.  Fruh. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol 80(2):1032-7, 2006.

125. Jarvis MA, and J. A. Nelson. Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal.  J. Virol 80(21):10591-9, 2006.

126. Streblow DN, KW vanCleef, C Kreklywich, C Meyer, P Smith, V DeFilippid, F. Grey, K Fruh, R. Searles, C. Bruggeman, C. Vink, J.A. Nelson and SL Orloff.  Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro.  J. Virol 81(8):3816-26, 2007.

127. Grey F., H Meyers, E. A. White, D. H. Spector, and J.A. Nelson. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLOS Pathogens 3 (11):e163; 2007

128. Medigeshi, G. R., A. M. Lancaster, A. J., Hirsch, T. Briese, W. I. Lipkin, J Nikolich-Zugich and J. A. Nelson. West Nile virus infection activates the unfolded protein response leading to CHOP induction and apoptosis. J. Virol. 81:10849-10860; 2007

129. Streblow, D. N., K. W. R. van Cleef, C. N. Kreklywich, C. Meyer, P. Smith, V. Defilippis, F. Grey, K. Frueh, R. Searles, C. Bruggeman, C. Vink, J.A. Nelson, S. L. Orloff. Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J. Virol 81:3816-3826; 2007

130. Streblow, D. N., S. L. Orloff, and J. A. Nelson. Acceleration of allograft failure by cytomegalovirus. Current Opinion in Immunology 19: 577-582; 2007.

131.  Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson J.A., Jarvis MA, Johnson DC.  Characterization of the human cytomegaloviruse gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J. Virol. 2008 82(1):60-70 2007.

132. Streblow DN, KW vanCleef, C Kreklywich, C Meyer, P Smith, V DeFilippis, F. Grey, K Fruh, R. Searles, C. Bruggeman, C. Vink, J.A. Nelson and SL Orloff.  Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro.  J. Virol 81(8):3816-26, 2007.

133. Streblow DN, Kreklywich CN, Andoh T, Moses AV, Dumortier J, Smith PP, Defilippis V, Fruh K, Nelson JA, Orloff SL. The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants. Am J Transplant. 2008 8(2):277-87.

134. Nelson JA. Small RNAs and large DNA viruses. N Engl J Med. 2007 Dec 20;357(25):2630-2.

135. Grey, F, and J. A. Nelson. Identification and function of human cytomegalovirus microRNAs. J. Clin. Virol. 41:186-191. 2008

136. Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol. 2008 Jun;82(11):5212-9.

137. Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, Camp D, Smith RD, Orloff SL, Nelson JA. Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol. 2008 Jul;82(13):6524-35.

138. Streblow DN, Dumortier J, Moses AV, Orloff SL, Nelson JA. Mechanisms of cytomegalovirus-accelerated vascular disease: induction of paracrine factors that promote angiogenesis and wound healing. Curr Top Microbiol Immunol. 2008;325:397-415.

139.  Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN.  Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.  PLoS Pathog. 2009 Feb;5(2):e1000304.

140.  Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K, Trubey CM, Piatak M Jr, Lifson JD, Nelson JA, Jarvis MA, Picker LJ.  Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.  Nat Med. 2009 Mar;15(3):293-9.

141. Vomaske J, Nelson JA, Streblow DN.  Human Cytomegalovirus US28: a functionally selective chemokine binding receptor.  Infect Disord Drug Targets, 2009 Nov;9(5):548-56 PMID: 19594424

142. Goodman AG, Fornek JL, Medigeshi GR, Perrone LA, Peng X, Dyer MD, Proll SC, Knoblaugh SE, Carter VS, Korth MJ, Nelson JA, Tumpey TM, Katze MG. P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS Pathog. 2009 5(5):e1000438. PMCID: 2677460.

143. Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA. West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol 83: 6125-34. 2009. PMCID: 2687390

144.Hansen SG, Powers CJ, Richards R. Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Fruh K.  Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus.  Science 2010 Apr 2;328(5974):102-6. PMCID: 2883175

145.Willie PT, Knoche AJ, Nelson JA, Jarvis MA, Johnson DC. A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells.  J Virol 2010 84(5):2585-96. PMCID: 2820920

146. Grey F, R Tirabassi, H Meyers, G Wu, S McWeeney, L Hook, JA Nelson. A viral microRNA down-regulates multiple cell cycle genes through mRNA 5’UTRs. PLoS Pathog 2010 24;6(6):e1000967. PMCID: 2891821

147. Smith M S, DC Goldman, AS Bailey, DL Pfaffle, CN Kreklywich, DB Spencer, FA Othieno, DN Streblow, JV Garcia, WH Fleming, JA Nelson. Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host & Microbe 2010 16:8(3):284-91. PMCID: 2945885



BOOK CHAPTERS

1. McDougall, J.K., A.M. Beckman, D.A. Galloway, J.A. Nelson and D. Myerson.  Defined viral probes for the detection of HSV, CMV and HPV.  In:  Rapid Detection and Identification of Infectious Agents, D.T. Kingsbury and S. Falkow, eds., Academic Press, New York, 1984.

2. McDougall, J.K., F.M. Buonaguro, D.A. Galloway, J.A. Nelson and P.P. Smith.  DNA virus and EM studies in AIDS.  Acquired Immune Deficiency Syndrome. In:  UCLA/ICN Symposium on AIDS, 1984,  pp. 139-156.

3. Galloway, D.A., J.A. Nelson and J.K. McDougall.  Transformation of rodent cells by herpes simplex virus type 2 and cytomegalovirus.  In:  UCLA/ICN Symposium on AIDS.  1984.

4. Rice, G.P.A., R.D. Schrier, P.J. Southern, J. Nelson, P. Casali and M.B.A. Oldstone.  Cytomegalovirus and measles virus:  In vitro models for virus-mediated immunosuppression.  In:  Viral Mechanisms of Immunosuppression:  Progress in Leukocyte Biology, vol. I, N. Gilmore and M.A. Weinberg, eds. Alan R. Liss, Inc., New York, 1985, PP. 15-29.

5. Schrier, R.D., J.A. Nelson and M.B.A. Oldstone.  Interactions between human cytomegalovirus and peripheral blood cells.  In:  Human Herpesvirus Infections:  Pathogenesis, Diagnosis, and Treatment, C. Lopez and B. Roizman, eds., Raven Press, New York, 1987.

6. Gnann, J.W., J.B. McCormick, S. Mitchell, J.A. Nelson and M.B.A. Oldstone.Synthetic peptide reagents serologically distinguish among infections caused by HIV-1 strains and between HIV-1 and HIV-2 infections.  In Vaccines 88:  New Chemical and Genetic Approaches to Vaccination:  Prevention of Aids and Other Viral, Bacterial, and Parasitic Diseases, H. Ginsberg, F. Brown, R. Lerner and R. Chanock, eds., Cold Springs Harbor Laboratory, Cold Spring Harbor, New York, pp. 327-333, 1988.

7. Nelson, J.A., J.W. Gnann and P. Ghazal.  Regulation and tissue specific expression of human cytomegalovirus.  In:  Curr. Topics Microbiol. Immunol. 154:75-103, 1990.

8. Nelson, J.A., C. Ibanez, R. Schrier, C. Wiley and P. Ghazal.  Expression of cytomegalovirus in mononuclear cells.  In: Viruses that Affect the Immune System, H.Y. Fan et al., editors, Amer. Soc. for Microbiol., chapter 16, pp. 231-246, 1991.

9. Reynolds-Kohler, C., C. Wiley, and J.A. Nelson.  Cells infected by human immunodeficiency virus in vivo.  In:  Mechanisms and Specificity of HIV Entry into Host Cells.  N. Duzgunes, Plenum Publishing, New York, in press. 1991.

10. Wiley, C.A. and J.A. Nelson.  Role of cytomegalovirus infection in neurologic abnormalties of AIDS.  In:  Dev. in Virol., 1992.

11. Reynolds-Kohler, C., C. Wiley and J.A. Nelson.  Human immunodeficiency virus infection of fetal tissue.  In: Symposium on Local Immunity in Reproductive Tract Tissues, Oxford University Press, eds:P.D. Griffin and P.M. Johnson, pp.377-390, 1993.

12. Nelson, J.A., K. Fish, C. Ibanez, A. Depto, P. Ghazal, A. Moses and R. Jupp.  Dependence of cytomegalovirus replication on monocyte differentiation.  In:  Multidisciplinary approach to understanding cytomegalovirus disease.  Eds:S. Michelson and S.A. Plotkin, Elsevier Sci. Pub. 1993.

13. Moses, A.V. and J.A. Nelson.  An organ model for HIV infection of the blood brain barrier.  In:  Technical Advances in AIDS Reseach in the Nervous System.  Plenum Publishers, 1994

14. Soderberg-Naucler, C., K.N. Fish and J.A. Nelson.  Growth of human cytomegalovirus in primary macrophages. In: Methods: A Companion to Methods in Enzymology., Academic 16:126-138, 1998.

15. Soderberg-Naucler, C and J.A. Nelson.  Immunomodulation of Cytomegalovirus.  In: Effects of Microbes on the Immune System. Chapter  25: pgs 399-418  Eds:M. Cunningham and R. Fujinami.  Lippincott Williams & Wilkins Publishers , 2000.

16. Soderberg-Naucler, C. And J. A. Nelson. Cytomegalovirus. In Persistent Viral Infections. Chapter 10 pgs 209-242 Eds R.Ahmed and I. Chen. John Wiley and Sons Ltd. 1999.

17. Strelow, L..I. , D. Janigro and J.A. Nelson. 2001 The Blood-Brain Barrier and AIDS. In Advances in Virus Research, Vol 56, M. Buchmeier, Ed., 355-388.

18. Jarvis M, Nelson J. Human cytomegalovirus persistence and latency in endothelial cells and macrophages. Curr Opin Microbiol. 2002 Aug;5(4):403.

19. Jarvis MA, Nelson JA. Mechanisms of human cytomegalovirus persistence and latency.   Front Biosci. 2002 Jun 1;7:d1575-82

20,  Streblow, D. N., J. Dumortier, S. L. Orloff, and J. A. Nelson. Mechanisms of cytomegalovirus-accelerated vascular disease: Induction of paracrine factors that promote angiogenesis and wound healing.
PRE AND POSTDOCTORAL RESEARCH TRAINEES


NAME/           
TRAINING PERIOD

DEGREE

PREVIOUSLY TRAINED

CURRENT POSITION

Schrier, Rachel
1984-1988

Ph.D.

University of Colorado

Associate Professor, UCSD

Gnann, John
1985-1988

M.D.

Duke University at Birmingham

Assistant Professor, University of Alabama

Lathey, Janet
1988-1990

Ph.D.

LSU

Assistant Professor, UCSD

Ghazal, Peter
1988-1990

Ph.D.

NIH

Associate Member, Scripps Research Institute

Ibanez, Carlos
1992

Ph.D.

UCSD                 

Scientist, Viagene Inc.1989, La Jolla, CA

Baracchini, Edguardo
1990-1992

Ph.D.

University of Texas at Dallas

Vice President, Agouron

Jupp, Ray
1991-1993

Ph.D.

University of Cardiff, U.K.

Chief Scientist, RPR

Depto, Allison
1991-1993

Ph.D.

University of West Virginia

Assistant Professor, Diabetes Institute
at East Virginia Medical School

Moses, Ashlee
1991-1995

Ph.D.

University of Wallengong,
Australia

Assistant Professor, VGTI, OHSU

Stenglein, Stephan
1993-1996

M.D.

University of Erlangen,
Germany

Assistant Professor Univesity of Tubingen,
Germany

Fish, Kenneth
1994-1998

Ph.D.

University of California, San Diego, CA

Research Institute of Scripps Clinic

Williams, Sally
1994-1997

M.D.

University of Cincinnati

Assistant Professor Infectious Disease
OHSU

Söderberg, Cecilia
1995-1997

M.D./Ph.D.

Karolinska Institute
Stockholm, Sweden

Assistant Professor Karolinska Institute
Stockholm, Sweden

Mills, Lisa
1996-1997

Ph.D.

Oregon Health Sciences University, Portland, OR

Research Associate, VA
Hospital, Portland, OR

Strelow, Lisa
1996-2000

Ph.D.

Washington University
St. Louis, MO

Assistant Professor, US Davis, CA

Jarvis, Michael
1996-2001

Ph.D.

University California at Davis, Davis, CA

Assistant Professor, OHSU

Streblow, Daniel
1997-2001

Ph.D.

University of Wisconsin,
Madison, WI

Assistant Professor, OHSU

Henderson, Winnie 1998-2003

M.D./Ph.D.

University of Nevada, Reno NV

House Officer Surgery, OHSU

Ruchti, Franziska
1998-2002

Ph.D.

University of Bern,
Switzerland

Bioinformatics Program, OHSU

Hirsch, Alec
1999-2008

Ph.D.

Princeton University

Staff Scientist 1, VGTI, OHSU

Melnychuk, Ryan
2000-2005

Ph.D.

University of Alberta, Alberta, Canada

BioEthics Program, University of New Brunswick, Canada

Smith, Irene
2000-2002

Ph.D.

University of California
Irvine, CA

Research Assistant Professor, OHSU

Hansen, Scott
2001-2006

Ph.D.

Oregon State University
Corvallis, OR

Staff Scientist 2, VGTI, OHSU

Rue, Cary
2001-2004

Ph.D.

University of Tennessee
Memphis, TN

Center for Disease Control, Atlanta, GA

Dumortier, Jerome
2003-2009

Ph.D.

Heidelberg University
Germany

Studying nutrition in France

Grey, Finn
2002-2008

Ph.D.

Cambridge University

Staff Scientist 1, OHSU

Medigeshi, Guruprasad
2005-2008

Ph.D.

 University of Heidelberg, Germany

Scientist, Bangalore, India

Spence, Doran
2003-2006

M.D./Ph.D.

University of Oregon

Graduate Student, OHSU

Carmen Baca Jones
2001-2009

Ph.D.

University of California, Davis

Postdoctoral Fellow, La Jolla Institute for Allergy & Immunology, CA

Meyer, Christine
2000-Present

B.S.

University of Washington, WA

Graduate Student, OHSU

Vomaske, Jennifer
2005-

B.S.

Northwestern University

Graduate Student, OHSU

Smith, Michael Shane
2006-

Ph.D.

 Louisiana State University

Postdoctoral Fellow, OHSU

Hook, Lauren
2006-

Ph.D.

University of Pennsylvania, PA

Postdoctoral Fellow, OHSU

Jessica Smith
2008-

Ph.D.

University of Mexico, NM

Postdoctoral Fellow, OHSU


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