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VGTI in the News

The Art of Self- Defence (Nature) (click to download)

Alec Hirsch, Ph.D.

Publications
Smith JL, Stein DA, Shum D, Fischer MA, Radu C, Bhinder B, Djaballah H, Nelson JA, Früh K, Hirsch AJ. Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling. J Virol. 2014 May;88(10):5533-42. (doi: 10.1128/JVI.00365-14.) [PMID: 24599995, PMCID: PMC4019099] Epub 2014 Mar 5.

Fischer MA, Smith JL, Shum D, Stein DA, Parkins C, Bhinder B, Radu C, Hirsch AJ, Djaballah H, Nelson JA, Früh K. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep;87(17):9411-9. (doi: 10.1128/JVI.00101-13.) [PMID: 23824813, PMCID: PMC3754125] Epub 2013 Jul 3.

Smith JL, Grey FE, Uhrlaub JL, Nikolich-Zugich J, Hirsch AJ. Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. J Virol. 2012 May;86(9):5278-87. (doi: 10.1128/JVI.06883-11.) [PMID: 22345437, PMCID: PMC3347395] Epub 2012 Feb 15.

Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K. Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol. 2011 Oct;85(19):10154-66. (doi:10.1128/JVI.05298-11.) [PMID: 21795337, PMCID: PMC3196423] Epub 2011 Jul 27.

Hirsch AJ. The use of RNAi-based screens to identify host proteins involved in viral replication. Future Microbiol. 2010 Feb;5(2):303-11. (doi: 10.2217/fmb.09.121.) [PMID: 20143951, PMCID: PMC2864646]

Brien JD, Uhrlaub JL, Hirsch A, Wiley CA, Nikolich-Zugich J. Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med. 2009 Nov 23;206(12):2735-45. (doi: 10.1084/jem.20090222.) [PMID: 19901080, PMCID: PMC2806630] Epub 2009 Nov 9.

Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA. West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol. 2009 Jun;83(12):6125-34. (doi: 10.1128/JVI.02617-08.) [PMID: 19369347, PMCID: PMC2687390] Epub 2009 Apr 15.

Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol. 2008 Jun;82(11):5212-9. (doi: 10.1128/JVI.00008-08. ) [PMID: 18385233, PMCID: PMC2395215] Epub 2008 Apr 2.

Barklis E, Still A, Sabri MI, Hirsch AJ, Nikolich-Zugich J, Brien J, Dhenub TC, Scholz I, Alfadhli A. Sultam thiourea inhibition of West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2642-5. [PMID: 17452483, PMCID: PMC1913232] Epub 2007 Apr 23.

Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol. 2005 Sep;79(18):11943-51. [PMID: 16140770, PMCID: PMC1212629]

Melnychuk RM, Streblow DN, Smith PP, Hirsch AJ, Pancheva D, Nelson JA. Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol. 2004 Aug;78(15):8382-91. [PMID: 15254210, PMCID: PMC446127]