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VGTI in the News

The Art of Self- Defence (Nature) (click to download)

Jay Nelson, Director
Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases
Adjuvant Discovery Program: Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity
Molecular Aspects of Cytomegalovirus Latency
International Herpesvirus Workshop
Protective Immunity in Special Populations: Interface between Innate and Adaptive Immunity
Development of an Effector-Memory T Cell AIDS Vaccine (Project 2: Attenuation of CMV Vector Pathogenicity and Transmission by Altering Viral Tropism)
Collaboration for AIDS Vaccine Discovery (CAVD): Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Antiviral Drug Discovery and Development Center: Project 1: Identification and Development of Anti-Flavivirus Lead Drug Candidates
Antagonistic Viral Determinants Regulating the Outcome of Infection

Louis Picker, Co-Director
Collaboration for AIDS Vaccine Discovery (CAVD): Development of an Attenuated CMV Vector for an HIV/AIDS Vaccine
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV
Development of an Effector-Memory T Cell AIDS Vaccine
Role of Memory T Cell Dynamics in SIV Infection
Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors
Efficacy of Oral CMV/SIV Vectors
Efficacy of Oral CMV/SIV Vectors (Administrative Supplement)
OHSU/AERAS Project 2: Vector Production and Efficacy Experiment #2
DARE: Delaney AIDS Research Enterprise to Find a Cure: Project 2: Investigating the Impact of Homeostatic Proliferation on HIV Persistence
Consortium for AIDS Vaccine Research in Nonhuman Primates: Project 2: CMV Vectors and Early Control of Mucosal SIV Challenge
Evasion of Antigen Presentation by Rhesus Cytomegalovirus

Klaus Früh, Senior Scientist
Evasion of Antigen Presentation by Rhesus Cytomegalovirus
An Effector Memory T Cell-Inducing Subunit Vaccine against Malaria
Evaluation of Immunogenicity and Protection Conferred by CMV Vaccine Vectors against Plasmodium knowlesi Malaria in Rhesus Monkeys
Department of the Navy/Naval Medical Research Center (NMRC)
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Collaboration for AIDS Vaccine Discovery (CAVD): Development of an Attenuated CMV Vector for an HIV/AIDS Vaccine
Development of an Effector-Memory T Cell AIDS Vaccine: Project 1: Development and Analysis of Replication-Deficient CMV Vectors
Pacific Northwest Regional Center of Excellence: Project 8: Kinase Networks Controlling Flavivirus Replication
Mechanisms of Orthopoxvirus Host Control and Viral Immune Evasion: Project 3: T Cell Control by Coxpoxvirus
Project 1: Immunological Characterization of a Novel HCMV Vaccine Platform
Project 2: Safety and Immunogenicity of Single-Cycle HCMV in Non-Human Primates
Antiviral Drug Discovery and Development Center: Project 1: Identification and Development of Anti-Flavivirus Lead Drug Candidates
Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors
CMV-Vectored Cancer Vaccines
A Human Cytomegalovirus-based Immunotherapy for HIV-1

Scott Wong, Senior Scientist
Rhesus HHV-8 Homologue in AIDS-Related Malignancies
Rhesus HHV-8 Homologue in AIDS-Related Malignancies (Administrative Supplement)
Induction of Robust T Cell Response to RRV-LANA
Pacific NorthWest Regional Center of Excellence: Core B: Nonhuman Primate Core; Research Project 2: Broad-based strategies to improve T-cell mediated protection
Search for Novel Gamma-2 Herpesvirus in Multiple Sclerosis
Examining the Roles of microRNAs (miRNAs) in Japanese macaque encephalomyelitis (JME), a Model for Multiple Sclerosis (MS)

Michael Axthelm, Senior Scientist
Establishment of Specific Pathogen Free Rhesus and Pigtail Macaque Colonies
Evaluation of immunogenicity and protection conferred by CMV vaccine vectors against Plasmodium knowlesi malaria in rhesus monkeys
Oral, replicating Ad4-HIV vaccine development & evaluation in NHP challenge model
Rhesus HHV-8 Homologue in AIDS-related Malignancies
Evasion of antigen presentation by Rhesus Cytomegalovirus
Efficacy of Oral CMV/SIV Vectors
Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors
Development of Effector-Memory T Cell AIDS Vaccine
Consortium for AIDS Vaccine Research in Nonhuman Primates: Core F: Nonhuman Primate Core
DARE: Delaney AIDS Research Enterprise to Find a Cure: Project 2: Investigating the Impact of Homeostatic Proliferation on HIV Persistence; Project 3: Targeting the PD-1 Pathway to Eradicate SIV/HIV
Collaboration for AIDS Vaccine Discovery (CAVD): Development of an Attenuated CMV Vector for an HIV/AIDS Vaccine
Effector Memory T Cell-Inducing Subunit Vaccine against Malaria
Role of Memory T cell Dynamics in SIV Infection
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine
AERAS Project 2: Vector Production and Efficacy Experiment #2
Graft versus Host immunity in SIV Clearance Following Stem Cell Transplantation
Role of Graft versus Host in SIV Clearance Following Stem Cell Transplantation: Targeting HIV reservoirs via Y chromosome-specific graft vs host immunity
Pacific NorthWest Regional Center of Excellence: Core B – Nonhuman Primate Core
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV
Reducing Latent Viral Reservoirs in Infant Macaques
Programming HIV Immunity for Broadly Neutralizing Antibodies by Vaccination
An Unconventional, Effector Memory T cell Vaccine for Influenza

Ashlee Moses, Associate Scientist
Mechanisms of KSHV-Induced Cellular Transformation
Characterization of Vpu-mediated degradation of BST-2
The role of JM rhadinovirus (JMRV) infection of vascular endothelial cells in the pathogenesis of Japanese macaque encephalomyelitis (JME)

Daniel Streblow, Associate Scientist
Pacific Northwest Regional Center of Excellence Developmental Research Project: Identification of Age-Related Defects to CHIKV Infections in a NHP Model
Collaboration for AIDS Vaccine Discovery (CAVD): Development of an Attenuated CMV Vector for an HIV/AIDS Vaccine
Antiviral Drug Discovery and Development Center: Project 3: Novel Therapeutic Strategies Targeting Re-emerging Alphaviruses
CMV Vectored Herpes Simplex Vaccine
CMV-Vectored Cancer Vaccines
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV
Project 3: CMV-vectored Genital Herpesvirus Vaccine

Patrizia Caposio, Assistant Scientist
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Development of an Effector-Memory T Cell AIDS Vaccine: Project 2: Attenuation of CMV Vector Pathogenicity and Transmission by Altering Viral Tropism
A synthetic human cytomegalovirus vaccine platform

Victor DeFilippis, Assistant Scientist
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Adjuvant Discovery Program: Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity
Antiviral Drug Discovery and Development Center: Project 3: Novel Therapeutic Strategies Targeting Re-emerging Alphaviruses
Pacific NorthWest Regional Center of Excellence Developmental Research Project: Role of cytokines in Chikungunya virus-associated disease
Evasion of Antigen Presentation by Rhesus Cytomegalovirus

Scott Hansen, Assistant Scientist
Project 1: Immunological Characterization of a Novel HCMV Vaccine Platform
Project 2: Safety and Immunogenicity of Single-Cycle HCMV in Non-Human Primates
Development of an Effector-Memory T Cell AIDS Vaccine: Project 3: Enhancing RhCMV/SIV Vector Efficacy
Defining Non-classical CMV-induced CD8 T Cell Responses
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
OHSU/AERAS Project 2: Vector Production and Efficacy Experiment #2
An Effector Memory T Cell-Inducing Subunit Vaccine against Malaria
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV

Alec Hirsch, Assistant Scientist
Evaluation of Host miRNAs as Therapeutics against Encephalitogenic Flaviviruses
Adjuvant Discovery Program: Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity
Antiviral Drug Discovery and Development Center: Project 1: Identification and Development of Anti-Flavivirus Lead Drug Candidates
Protective Immunity in Special Populations: Interface between Innate and Adaptive Immunity
Pacific Northwest Regional Center of Excellence: Developmental Project: The role of microRNAs in flavivirus replication (DP006)

Afamefuna Okoye, Assistant Scientist
DARE: Delaney AIDS Research Enterprise to Find a Cure: Project 3: Targeting the PD-1 Pathway to Eradicate SIV/HIV
DARE: Delaney AIDS Research Enterprise to Find a Cure: Project 2: Investigating the Impact of Homeostatic Proliferation on HIV Persistence
Role of Memory T cell Dynamics in SIV Infection
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine
Elimination of long-lived latently infected T-cells in SIV-infected rhesus macaques (RM) on suppressive antiretroviral therapy (ART) with alemtuzumab-induced T-cell depletion

Haesun Park, Research Assistant Professor
Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors
Consortium for AIDS Vaccine Research in Nonhuman Primates: Project 2: CMV Vectors and Early Control of Mucosal SIV Challenge

Jonah Sacha, Assistant Scientist

Endogenous Retrovirus-specific Antibodies to Block AIDS Virus Infection
Defining Non-classical CMV-induced CD8 T Cell Responses
Defining and Eliminating the Macrophage Reservoir
Graft versus Host Immunity in SIV Clearance Following Stem Cell Transplantation
Targeting HIV Reservoirs via Y Chromosome-specific Graft versus Host Immunity
32nd Annual Symposium on NHP Models for AIDS
An Unconventional, Effector Memory T cell Vaccine for Influenza
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV
Targeting Tim-3 for Elimination of HIV Reservoirs
A Novel APOBEC-based Vaccine Approach for HIV
Reducing Latent Viral Reservoirs in Infant Macaques
Oral, replicating Ad4-HIV vaccine development & evaluation in NHP challenge model
Reducing Latent Viral Reservoirs in Infant Macaques

Rebecca Skalsky, Assistant Scientist

The Role of Viral and Cellular miRNAs in B-cell Lymphomagenesis