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VGTI in the News

The Art of Self- Defence (Nature) (click to download)

Jay Nelson, Director
Antagonistic Viral Determinants Regulating the Outcome of Infection.
Antiviral Drug Discovery and Development Center: Project 1: Identification and Development of Anti-Flavivirus Lead Drug Candidates.
International Herpesvirus Workshop.
Molecular Aspects of Cytomegalovirus Latency.
Protective Immunity in Special Populations: Interface between Innate and Adaptive Immunity.
Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity
Training Program in Virology.

Louis Picker, Co-Director
CMV Vectors and Early Control of Mucosal SIV Challenge.
Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors.
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine.
Development of an Attenuated CMV Vector for an HIV/AIDS Vaccine (Obj 1): To determine the ability of prototype Δpp71 RhCMV/SIV vectors encoding homologous vs. heterologous SIV inserts to protect against highly pathogenic mucosal SIVmac239 challenge.
Development of an Effector-Memory T Cell AIDS Vaccine: P01 Program Project Grant.
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine.
Efficacy of Oral CMV/SIV Vectors.
Investigating the Impact of Homeostatic Proliferation on HIV Persistence.
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV (Induction of Broad Functional Class II Restricted CD8+ T Cell Responses: Translation from NHP to Humans).
OHSU/AERAS Project 2: Vector Production and Efficacy Experiment #2.
Role of Memory T Cell Dynamics in SIV Infection.

Klaus Früh, Senior Scientist
A Human Cytomegalovirus-based Immunotherapy for HIV-1.
A Therapeutic Vaccine for Cervical Cancer: Task 1: Vector Construction.
An Effector Memory T Cell-Inducing Subunit Vaccine against Malaria.
CMV-Vectored Cancer Vaccines.
Evaluation of Immunogenicity and Protection Conferred by CMV Vaccine Vectors against Plasmodium knowlesi Malaria in Rhesus Monkeys.
Evasion of Antigen Presentation by Rhesus Cytomegalovirus.
Mechanisms of Orthopoxvirus Host Control and Viral Immune Evasion: Project 3: T Cell Control by Cowpoxvirus.
Project 1: Immunological Characterization of a Novel HCMV Vaccine Platform.
Project 2: Safety and Immunogenicity of Single-Cycle HCMV in Non-Human Primates.

Scott Wong, Senior Scientist
Induction of Robust T Cell Response to RRV-LANA.
Isolation of a Novel Gamma-herpesvirus from Multiple Sclerosis Patients.
Search for Novel Gamma-2 Herpesvirus in Multiple Sclerosis.

Michael Axthelm, Senior Scientist
Core F1: Nonhuman Primate Core.
Establishment of Specific Pathogen Free Rhesus and Pigtail Macaques Colonies.

Ashlee Moses, Associate Scientist
Characterization of Vpu-mediated degradation of BST-2.

Daniel Streblow, Associate Scientist
Antibody-Based Therapy of Chikungunya Virus.
Antiviral Drug Discovery and Development Center: Project 3: Novel Therapeutic Strategies Targeting Re-emerging Alphaviruses.
CMV Vectored Herpes Simplex Vaccine.
Project 3: CMV-vectored Genital Herpesvirus Vaccine.

Patrizia Caposio, Assistant Scientist
A Synthetic Human Cytomegalovirus Vaccine Platform.

Scott Hansen, Assistant Scientist
Project 1: Immunological Characterization of a Novel HCMV Vaccine Platform
Project 2: Safety and Immunogenicity of Single-Cycle HCMV in Non-Human Primates
Development of an Effector-Memory T Cell AIDS Vaccine: Project 3: Enhancing RhCMV/SIV Vector Efficacy
Defining Non-classical CMV-induced CD8 T Cell Responses
Development of a CMV Vector-Based Therapeutic HIV/AIDS Vaccine
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
OHSU/AERAS Project 2: Vector Production and Efficacy Experiment #2
An Effector Memory T Cell-Inducing Subunit Vaccine against Malaria
MHC II- and MHC E-restricted CD8+ T Cells and Control of HIV

Alec Hirsch, Assistant Scientist
Evaluation of Host miRNAs as Therapeutics against Encephalitogenic Flaviviruses.

Afamefuna Okoye, Assistant Scientist
Elimination of Long-lived Latently Infected T-cells in SIV-infected Rhesus Macaques (RM) on Suppressive Antiretroviral Therapy (ART) with Alemtuzumab-induced T-cell Depletion.
Purging the Latent HIV Reservoir at ART Initiation: a New Eradication Strategy.
Impact of Alemtuzumab on SIV Persistence in Antiretroviral-Treated SIV-Infected Macaques.
Targeting the PD-1 Pathway to Eradicate SIV/HIV.

Jonah Sacha, Assistant Scientist

A Novel APOBEC-based Vaccine Approach for HIV.
A Universal MHC-E-restricted T Cell Vaccine for HIV.
An Unconventional, Effector Memory T Cell Vaccine for Influenza.
Defining and eliminating the macrophage reservoir.
Defining Non-classical, CMV-induced CD8 T Cell Responses.
Endogenous Retrovirus-specific Antibodies to Block AIDS Virus Infection.
Graft versus host immunity in SIV clearance following stem cell transplantation..
Hepatitis B Virus Infection of Nonhuman Primates.
Oral, Replicating Ad4-HIV Vaccine Development & Evaluation in NHP Challenge Model.
Role of Graft Versus Host in SIV Clearance Following Stem Cell Transplantation.
Targeting Tim-3 for Elimination of HIV Reservoirs.

Rebecca Skalsky, Assistant Scientist

Examining the Roles of microRNAs (miRNAs) in Japanese Macaque Encephalomyelitis (JME), a Model for Multiple Sclerosis (MS).
The Role of Viral and Cellular miRNAs in B-cell Lymphomagenesis.

Lisi Amsler, Graduate Student
Characterization of a novel inflammasome inhibition phenotype by Human Cytomegalovirus.

Sara Botto, Graduate Student
The Role of heme oxygenase-1 (HO-1) in Kaposi Sarcoma, a KSHV-induced Angioproliferative Tumor.