Klaus Fruh, Ph.D.

Selected References

Hansen, S. G., C. Powers, R. Richards, A. B. Ventura, J. C. Ford, D. Siess, M. K. Axthelm, J. A. Nelson, M. A. Jarvis, L. J. Picker, and K. Früh. 2010. Evasion of CD8+ T cells is critical for super-infection by cytomegalovirus Science accepted for publication. NIHMS178807

Defilippis, V. R., D. Alvarado, T. Sali, S. Rothenburg, and K. Früh. 2009. Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1. J Virol 84:585-598. PMC2798427

Powers, C. J., and K. Früh. 2008. Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus. PLoS Pathog 4:e1000150. PMC2542416

DeFilippis, V. R., B. Robinson, T. M. Keck, S. G. Hansen, J. A. Nelson, and K. Früh. 2006. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol 80:1032-7. PMC1346858

DeFilippis, V., and K. Früh. 2005. Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3. J Virol 79:6419-31. PMC1091669

Pande, N. T., C. Powers, K. Ahn, and K. Früh. 2005. Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11. J Virol 79:5786-98. PMC1082751

Park, B., Y. Kim, J. Shin, S. Lee, K. Cho, K. Früh, S. Lee, and K. Ahn. 2004. Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion. Immunity 20:71-85. PMID14738766

Paulson, E., C. Tran, K. Collins, and K. Fruh 2001. Kshv-k5 inhibits phosphorylation of the major histocompatibility complex class i cytoplasmic tail. Virology. 288:369-78.

Simmen K.A., Singh J., Luukkonen B.G.M., Lopper M., Bittner A., Miller N.E., Jackson M.R., Compton T., and K. Früh "Global Modulation of Cellular Transcription by Human Cytomegalovirus is Initiated by Viral Glycoprotein B" Proc. Natl. Acad. USA, 2001, 98:7140-7145.

Früh. K., Simmen K., Luukkonen B. G. M., Bell Y. C., and Ghazal P. (2001). "Virogenomics: a novel approach to antiviral drug discovery." Drug Discovery Today 6(12), 601-608.

Gruhler A., Peterson P.A. and K. Früh "Human cytomegalovirus immediate early glycoprotein US3 retains MHC class I molecules by transient association", (Traffic, 1: 318-325, 2000).

Gruhler, A. and K. Früh "Control of MHC class I traffic from the endoplasmic reticulum by cellular chaperones and viral anti-chaperones, Traffic", 1:306-311, 2000.

Preckel, T., Leung, W.-P., Cai, Z., Vitiello, A., Salter-Cid, L., Winqvist, O., Wolfe, T.G, Von Herrath, M., Angulo, A., Ghazal, P., Lee, J.-D., Fourie, A.M., Wu, Y., Pang, J., Ngo, K., Peterson, P.A.; Früh, K*. & Yang, Y.* "Impaired Immunoproteasome Assembly and Immune responses in PA28-/- Mice" Science, 286:2162-2165, 1999 (* corresponding authors)

Schoenhals G. J., R. M. Krishna, A. G. Grandea III, T. Spies, P. A. Peterson, Y. Yang and K. Früh "Retention of empty MHC class I molecules by Tapasin is essential to reconstitute antigen presentation in invertebrate cells". EMBO-J., 15:3247-3255, 1999.

Früh K., Gruhler A., Krishna M.R. and G. Schoenhals "A comparison of viral immune escape strategies targeting the MHC class I assembly pathway", Immunol. Rev., 168:157-166, 1999.

Früh K. and Y. Yang "Antigen presentation and its regulation by interferon-gamma" Curr. Op. Immunol., 11: 76-81, 1999.
Ahn K., A. Gruhler, P. A. Peterson, Y. Yang and K. Früh "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP", Immunity, 6: 613-621, 1997.

Früh K., Karlsson L. and Y. Yang "Interferon-gamma in antigen processing and presentation, In: Gamma Interferon: A pleiotropic cytokine with antiviral activity" (Ed. G. Karupiah), R. G. Landes, Austin,Texas, 39-59. 1997.

Früh K., Ahn K. and P. A. Peterson "Inhibition of MHC class I antigen presentation by viral proteins" J. Mol. Med. 75: 33-42, 1997.

Ahn K., A. Angulo, P. Ghazal, P. A. Peterson, Y. Yang and K. Früh "Human cytomegalovirus inhibits antigen presentation by a sequential multistep process", Proc. Natl. Acad. USA, 93: 10990-10995, 1996.

Ahn K., T. H. Meyer, S. Uebel, P. Sempè, H. Djaballah, Y. Yang, P. A. Peterson, K. Früh* and R. Tampè "Molecular mechanism and species specificity of TAP inhibition by Herpes simplex virus protein ICP47". EMBO J., 15: 3247-3255, 1996 (*corresponding author).

Früh, K., K. Ahn, H. Djaballah, P. Sempè,, P. M. v. Endert, R. Tampè,, P. A. Peterson and Y. Yang. " A viral inhibitor of peptide transporters for antigen presentation" Nature, 375: 415-418, 1995.

Früh, K., M. Gossen, K. Wang, H. Bujard, P. A. Peterson and Y. Yang. "Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: A newly discovered mechanism for modulating the multicatalytic proteinase complex" EMBO J., 13: 3236-3244, 1994.

Früh, K., Y. Yang, D. Arnold, J. Chambers, L. Wu, J. B. Waters, T. Spies and P. A. Peterson. "Alternative exon usage and processing of the MHC-encoded proteasome subunits." J.Biol.Chem. 267: 22131-22140, 1992.

Früh main

HCMV

KSHV

Further references