Klaus Fruh, Ph.D.

Selected References
Paulson, E., C. Tran, K. Collins, and K. Fruh 2001. Kshv-k5 inhibits phosphorylation of the major histocompatibility complex class i cytoplasmic tail. Virology. 288:369-78.

Simmen K.A., Singh J., Luukkonen B.G.M., Lopper M., Bittner A., Miller N.E., Jackson M.R., Compton T., and K. Früh "Global Modulation of Cellular Transcription by Human Cytomegalovirus is Initiated by Viral Glycoprotein B" Proc. Natl. Acad. USA, 2001, 98:7140-7145.

Früh. K., Simmen K., Luukkonen B. G. M., Bell Y. C., and Ghazal P. (2001). "Virogenomics: a novel approach to antiviral drug discovery." Drug Discovery Today 6(12), 601-608.

Gruhler A., Peterson P.A. and K. Früh "Human cytomegalovirus immediate early glycoprotein US3 retains MHC class I molecules by transient association", (Traffic, 1: 318-325, 2000).

Gruhler, A. and K. Früh "Control of MHC class I traffic from the endoplasmic reticulum by cellular chaperones and viral anti-chaperones, Traffic", 1:306-311, 2000.

Preckel, T., Leung, W.-P., Cai, Z., Vitiello, A., Salter-Cid, L., Winqvist, O., Wolfe, T.G, Von Herrath, M., Angulo, A., Ghazal, P., Lee, J.-D., Fourie, A.M., Wu, Y., Pang, J., Ngo, K., Peterson, P.A.; Früh, K*. & Yang, Y.* "Impaired Immunoproteasome Assembly and Immune responses in PA28-/- Mice" Science, 286:2162-2165, 1999 (* corresponding authors)

Schoenhals G. J., R. M. Krishna, A. G. Grandea III, T. Spies, P. A. Peterson, Y. Yang and K. Früh "Retention of empty MHC class I molecules by Tapasin is essential to reconstitute antigen presentation in invertebrate cells". EMBO-J., 15:3247-3255, 1999.

Früh K., Gruhler A., Krishna M.R. and G. Schoenhals "A comparison of viral immune escape strategies targeting the MHC class I assembly pathway", Immunol. Rev., 168:157-166, 1999.

Früh K. and Y. Yang "Antigen presentation and its regulation by interferon-gamma" Curr. Op. Immunol., 11: 76-81, 1999.

Ahn K., A. Gruhler, P. A. Peterson, Y. Yang and K. Früh "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP", Immunity, 6: 613-621, 1997.

Früh K., Karlsson L. and Y. Yang "Interferon-gamma in antigen processing and presentation, In: Gamma Interferon: A pleiotropic cytokine with antiviral activity" (Ed. G. Karupiah), R. G. Landes, Austin,Texas, 39-59. 1997.

Früh K., Ahn K. and P. A. Peterson "Inhibition of MHC class I antigen presentation by viral proteins" J. Mol. Med. 75: 33-42, 1997.

Ahn K., A. Angulo, P. Ghazal, P. A. Peterson, Y. Yang and K. Früh "Human cytomegalovirus inhibits antigen presentation by a sequential multistep process", Proc. Natl. Acad. USA, 93: 10990-10995, 1996.

Ahn K., T. H. Meyer, S. Uebel, P. Sempè, H. Djaballah, Y. Yang, P. A. Peterson, K. Früh* and R. Tampè "Molecular mechanism and species specificity of TAP inhibition by Herpes simplex virus protein ICP47". EMBO J., 15: 3247-3255, 1996 (*corresponding author).

Früh, K., K. Ahn, H. Djaballah, P. Sempè,, P. M. v. Endert, R. Tampè,, P. A. Peterson and Y. Yang. " A viral inhibitor of peptide transporters for antigen presentation" Nature, 375: 415-418, 1995.

Früh, K., M. Gossen, K. Wang, H. Bujard, P. A. Peterson and Y. Yang. "Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: A newly discovered mechanism for modulating the multicatalytic proteinase complex" EMBO J., 13: 3236-3244, 1994.

Früh, K., Y. Yang, D. Arnold, J. Chambers, L. Wu, J. B. Waters, T. Spies and P. A. Peterson. "Alternative exon usage and processing of the MHC-encoded proteasome subunits." J.Biol.Chem. 267: 22131-22140, 1992.

A listing of publications by Dr. Früh is available from the National Library of Medicine