Categories | Inventors

pLXSN human KIT D816F retrovirally transduced BaF3 cells

OHSU # 1658-C

Categories:

• Biological Materials
• Biological Materials - Cell Lines
• Research Tools
• Research Tools - Screening

Inventors:

• Michael Heinrich, SM.Medicine

Technology Overview
Neomycin resistant and growth factor independent. This cell line expresses high levels of activated KIT. In addition to the engineered D816F mutation, the cells also acquired the following mutations due to retrovirus recombination events: I571M and M903I. These secondary events do not appear to alter the kinase properties of KIT or alter the pattern of KIT D816F sensitivity/resistance to kinase inhibitors.

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Dennis Hanson
Technology Development Manager
503-494-5861