Categories | Inventors
pLXSN human KIT D816Y retrovirally transduced BaF3 cells
OHSU # 1658-B
Categories:
Inventors:
- Michael Heinrich, SM.Medicine
Technology Overview
Neomycin resistant
and growth factor independent. This cell line expresses high levels of activated
KIT. In addition to the engineered D816Y mutation, the cells also acquired the
following mutations due to retrovirus recombination events: N587S and deletion
of amino acids 931-961. These secondary events do not appear to alter the kinase
properties of KIT or alter the pattern of D816Y sensitivity/resistance to kinase
inhibitors.
For more information, contact:
Dennis Hanson
Technology Development Manager
503-494-5861
