Methods for Promoting Nerve Regeneration Using Centella Asiatica Compounds
OHSU # 0761
Centella asiatica extracts promote nerve regeneration. Following traumatic or disease-induced axonal degeneration or transaction in the peripheral nervous system, axonal regeneration and neural network re-connectivity may ensue, often resulting in at least partial functional recovery. However, the new axons extend randomly, and are often misdirected. Recovery is also slow as the rate of axonal elongation is slow.
Centella asiatica herb, commonly known as "gotu kola", is an Indian medicinal plant used for over 200 years. Modern uses of this herb include treatment of psoriasis, skin ulcers, wound healing, leprosy, and as a general "nerve tonic" and memory booster. However, there has previously been no knowledge of specific components or compounds of Centella asiatica extracts that have activity specifically for nerve regeneration.
In vitro studies show that certain Centella asiatica extracts elicit a marked increase in neurite elongation in human SH-SY5Y cells to a significantly greater degree than FK506 which is used as a positive control. In vivo, these extracts have been tested in a sciatic nerve crush model with oral administration. Functional recovery was observed earlier and progressed more rapidly in Centella asiatica extract treated animals. Furthermore, regenerated axons in the treated animals were larger in size and demonstrated more and thicker myelin sheaths indicating more advanced axon regeneration (i.e., grew at a faster rate).
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Today, there is still no way to reverse damage to the spinal cord following injury. Researchers are working on new treatments, including innovative treatments, prostheses and medications that may promote nerve cell regeneration or improve the function of the nerves that remain after a spinal cord injury, but no successful treatment currently exists.
Pending patent application in the United States.
J Pharm Pharmacol. 2005 Sep;57(9): 1221-9
OHSU 761 is currently available for exclusive licensing.
- Amala Soumyanath, SM.Neurology
- Bruce Gold, SM.Neurology
- Sandra Gold, CR.Center for Research on Occupational and Environmental Toxicology
- Yong-Ping Zhong, ST.Stem Cell Center
- Dennis Bourdette, SM.Neurology
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Technology Development Manager