MC5-R Knockout mice
OHSU # 0387-B
MC5-R is responsive to all melanocortins at physiological levels except g-MSH. The melanocortin-5 receptor (MC5-R) is found in a wide range of tissues from skeletal muscle, to adipose tissues, brain, lung, adrenal and stomach. Provided by this invention is a mouse model with a disruption of the MC5-R gene with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. Analysis of these mice revealed a requirement for MC5-R gene expression in multiple exocrine glands in vivo for the production of a diverse set of products, including lipids, proteins, and porhyrins, and suggested the existence of a coordinated system for the regulation of exocrine gland function by melanocortin peptides, related to thermoregulatory homeostasis, tear production and the production of skin and hair oils. This model would be useful for the development of MC5-R receptor agonists and antagonists for the regulation of such biological processes and mediation of stress-induced response and pheromone production.
Close to 100% of people between the ages of twelve and seventeen have at least an occasional whitehead, blackhead or pimple, regardless of race or ethnicity. Many of these young people are able to manage their acne with over-the-counter (nonprescription) treatments. For some, however, acne is more serious. In fact, by their mid-teens, more than 40% of adolescents have acne severe enough to require some treatment by a physician. The prescription acne market is estimated at around $2.5-3Billion a year. Symptoms associated with Dry Eye Syndrome, a lacrimal gland disorder, account for up to 40% of all ophthalmologist visits.
The disease affects some 10 million patients in North America and Europe. A sub-segment of patients are affected by Sjogren's syndrome, which is an autoimmune disease affecting typically the eye (dry eye), epithelial tissues in the mouth (dry mouth) and joints; Sjogren's affects at least 1% of the population.
Roger Cone earned his Ph.D. in Biology from the Massachusetts Institute of Technology in 1985. He received his B.A. in Biochemistry from Princeton University. Starting in 1985, Cone was a fellow at the Cold Spring Harbor Laboratory. In 1988, he became an assistant professor in the Division of Molecular Medicine at the New England Medical Center, where he remained until he accepted his appointment to the Vollum in 1990. Cone moved to Vanderbilt University in 2008 and is the Chair of the Department of Molecular Physiology and Biophysics.
Wenbiao Chen received his Ph.D. degree from the Department of Cell and Developmental Biology at OHSU in 1997. He holds a B.S. from Hunan Normal University and a M.S. from Washington State University. He did four years of postdoctoral research in the Massachusetts Institute of Technology Center for Cancer Research and was appointed as an assistant scientist in the Vollum Institute in 2001.
Malcolm Low received his Ph.D. in Neuroscience from Tufts University in 1987. He earned his B.S. from Rensselaer Polytechnic Institute and his M.D. from Albany Medical College. He did an internship and residency at Michael Reese Hospital in Chicago and then spent three years as a clinical and research fellow in Neuroendocrinology at the New England Medical Center. From 1985 to 1989, Low held concurrent positions on the faculty at Tufts and as a physician at the Medical Center. He came to the Vollum Institute in 1990 and was promoted to scientist in 1994. He holds a joint appointment as professor in the Department of Behavioral Neuroscience in the School of Medicine and is a founding member of the newly created Center for the Study of Weight Regulation and Associated Disorders at OHSU.
Cell. 1997 Dec 12;91(6):789-98
Breeding pairs of this MC5-R knockout mouse strain are available for non-exclusive licensing.
For more information, contact:
Technology Development Manager