D2 Dopamine Receptor Knock-Out Mice
OHSU # 0405
D2R is the gene for the D2 dopamine receptor and encodes a member of the D2-like class of dopamine receptors. It is one of the most abundant dopaminergic receptors expressed in the brain. This strain could be used to screen and assess agonist and antagonist drugs specific to the D2 receptor. These mutant mice could also provide a novel experimental system with which to study the role of dopamine in numerous brain functions, CNS-related diseases, addiction, depression, and anxiety-related disorders. They provide an excellent model for Parkinsonís disease. In addition, these mice could be useful in better determining the role of dopamine in heart, renal and eye function.
Breeding pairs are available which have been backcrossed on the congenic C57BL/6J background.
No other D2 receptor knock-out mice are known to exist.
Malcolm Low received his Ph.D. in Neuroscience from Tufts University in 1987. He earned his B.S. from Rensselaer Polytechnic Institute and his M.D. from Albany Medical College. He did an internship and residency at Michael Reese Hospital in Chicago and then spent three years as a clinical and research fellow in Neuroendocrinology at the New England Medical Center. From 1985 to 1989, Low held concurrent positions on the faculty at Tufts and as a physician at the Medical Center. He came to the Vollum Institute at OHSU in 1990 and was promoted to scientist in 1994. He holds a joint appointment as professor in the Department of Behavioral Neuroscience in the School of Medicine.
David Grandy received his Ph.D. from Michigan State University in 1985. Dr. Grandyís training was in both microbiology and molecular biology. For the last 25 years his research has focused on the cloning and deorphanization of G protein-coupled receptors (GPCRs) and the discovery of novel ligands for these receptors. Dr. Grandy is currently a Professor in the Physiology & Pharmacology Department at OHSU and joint appointment in the Department of Cell and Developmental Biology.
Kelly et al. Neuron 1997, 19(1):103-113
Breeding pairs are available for non-exclusive licensing.
For more information, contact:
Technology Development Manager