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cDNA Clone Encoding the RGK5 (Kv1.3) Voltage-Gated Potassium Channel

 

OHSU # 0382

Summary:

Technology Overview

Low stringency hybridization screening of a rat genomic DNA library with a previously described cDNA clone encoding a rat voltage-gated potassium channel has resulted in the characterization of a member of the potassium channel family, RGK5. An uninterrupted nucleotide sequence encodes a protein 525 amino acids in length, revealing that the entire coding region resides on a single exon. RGK5 transcripts are present in both mouse thymus and rat brain, as determined by Northern blot analysis. RNA transcribed in vitro from RGK5 genomic DNA directs the expression of functional potassium currents after injection into Xenopus oocytes. The currents are activated by depolarization, being half-activated at -14mV, and inactivate almost completely during depolarizations of 1 to 2 s. The properties of the currents strongly resemble those of the type n potassium channel present on both immature tymocytes and T lymphocytes.

Inventor Profile

John Adelman received his Ph.D. in Microbiology from OHSU in 1988. He holds a B.S. and an M.S. in Microbiology from the University of Connecticut. After a year as a research assistant at Yale University, he spent five years as a research associate at Genentech. He arrived at the Vollum Institute in 1985, where he did his graduate research. After receiving his Ph.D., he accepted a faculty position at the Vollum and was promoted to senior scientist in 1998. Adelman holds concurrent appointments in the Departments of Cell and Developmental Biology and Molecular and Medical Genetics in the School of Medicine.

Publication

J Immunol. 1990 Jun 15;144(12):4841-50

Licensing Opportunity

The cDNA clone is available for non-exclusive licensing.

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Trina Voss
Technology Development Manager
503-494-9839

OptionPrice
(terms)  $2000.00