Mouse lines for the conditional elimination of the expression of the peripheral benzodiazapine receptor
OHSU # 1455
The peripheral benzodiazepine receptor (PBR) is an 18 kDa, highly hydrophobic protein located in the outer mitochondrial membrane that was initially identified as a binding site for benzodiazepines in tissues that lack GABA receptors, the clinical target of benzodiazepines in the central nervous system.
Mouse lines have been generated in which the gene encoding PBR (Tspo) contains loxP sites for conditional elimination of PBR expression using widely available genetic strategies.
Through the years, the PBR has been proposed to play a key role in the import of precursors into the mitochondria for sterol synthesis and as a key component of the permeability transition pore, which has been demonstrated to play a key role in many of the pathologies associated with cellular Ca2+ overload.
Genetic tests of the role of the PBR in mouse models of human disease have been hampered by the observation that animals lacking expression of the PBR (non-conditional mutants) results in embryonic lethality. Therefore, no comparable animal model exists.
The inventors plan on crossing to a variety of Cre expressing lines
The mice are available for non-exclusive licensing.
For more information, contact:
Technology Development Manager