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MicroRNA inhibitors to enhance radiotherapy efficacy

 

OHSU # 2414

Technology Overview:

Almost 50% of cancer patients undergo some form of radiotherapy; however only half of these patients have a significant response to this treatment. Higher doses of radiation can be effective, but often result in damage to nearby healthy organs.  One approach to increase radiotherapy sensitivity of the targeted tissue is to enhance the efficacy of lower/normal dose radiation. This is particularly critical for cancers that respond well to radiation, but where toxicity may limit the use of this treatment regimen.  Examples include brain tumors, especially in the pediatric setting, as radiation can decrease IQ, as well as in liver and colorectal cancers.

 

Researchers at OHSU have identified a microRNA (miR) which, when inhibited, surprisingly inhibits tumor cell proliferation and enhances the sensitivity of normal-dose radiation therapy in vivo.  The miR can also be used as a biomarker for predicting efficacy of radiation sensitizers/neoadjuvant treatment or to predict the efficacy of radiation therapy.

 

Technology at a glance:

•       A miRNA target which can be used as a radiation sensitizer to enhance radiotherapy in cancer tissues

•       Inhibition of identified miRNA reduces tumor cell proliferation and tumor burden in vivo

•       A micro-RNA as a biomarker for predicting efficacy of radiation sensitizers/neoadjuvant treatment or to predict the efficacy of radiation therapy.

 

Publication

1.       Rana S, Espinosa C, Thomas CR Jr, Anand S:  Differential expression of microRNA between standard conventional dose versus ablative dose radiation in colorectal cancer.  Proc of the 99th Annual Meeting of the American Radium Society, The Broadmoor, Colorado Springs, May 6-9, 2017

2.       Rana S, Kelley K, Ruhl R, Thomas CR Jr, Tsikitis L, Anand S: MicroRNA regulation of radiation sensitivity in colorectal cancer. AACR Annual Meeting 2017.

 

Intellectual Property

U.S. provisional patent application filed 3/31/3017

 

Licensing Opportunity

This technology is available for exclusive licensing.

 

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For more information, contact:

Anne Carlson
Technology Development Manager
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