Categories | Inventors

CRISPR/Cas9-targeted correction of heterozygous mutations in human preimplantation embryos

 

OHSU # 2391

Technology Overview:

More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2, associated with a high risk of breast and ovarian cancers and MYBPC3 causing hypertrophic cardiomyopathy (HCM).  OHSU has a proprietary method to correct a mutant allele of a gene of interest in an embryo allowing homology-directed repair to prevent transmission of monogenic inherited disorders such as HCM.

More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2, associated with a high risk of breast and ovarian cancers and MYBPC3 causing hypertrophic cardiomyopathy (HCM).  OHSU has a proprietary method to correct a mutant allele of a gene of interest in an embryo allowing homology-directed repair to prevent transmission of monogenic inherited disorders such as HCM.

Inventors:

Patents:

Patents Filed

Categories:

For more information, contact:

Travis Cook
Senior Technology Development Manager
503-494-3229