Human Oocytes Generated By Nuclear Transfer
OHSU # 2347
Because of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss, as well as birth defects are common. The main cause of this type of infertility, as several findings implicate, is the decline in oocyte quality associated to cytoplasmic deficiencies and mitochondrial dysfunction. Although assisted reproductive technologies can circumvent many cases, their efficacy is limited by the number and quality of available oocytes calling for the development of additional sources of competent, patient-related oocytes.
Researchers at Oregon Health & Science University discovered a novel method of generating functional human oocytes. The technique utilizes otherwise developmentally discarded first polar body (PB1) genomes for nuclear transfer (PBNT) which increase the yield of patient-matched viable embryos for transfer and thus increased pregnancy rates of approximately 40%. Additionally, given that PB1 hosts only a few mitochondria, the use of PBNT could be expanded to support mitochondrial replacement therapy, an approach to prevent maternal transmission of mtDNA-based disease.
Mitalipov, S. et al. Functional Human Oocytes Generated by Transfer of Polar Body Genomes. Cell Stem Cell, 20, 112-119 (2016).
Provisional patent application filed.
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