Mammalian Opioid Receptor Ligand and Uses (Orphanin FQ)
OHSU # 0346
- Biological Materials - Receptors/Targets
- Therapeutics - Neurology
- Biological Materials - Protein/Peptides
- Biological Materials
Technology 0346 relates to a novel mammalian opioid receptor protein and ligands that bind to such proteins. The invention is directed toward the isolation, characterization and pharmacological use of an endogenous ligand that specifically binds to a novel mammalian opioid receptor protein heterologously expressed in mammalian cells.
The invention specifically provides the isolated peptide ligand and analogues, derivates and variants thereof. The invention specifically provides tyrosine substitution variants of the peptide ligand that specifically bind to the opioid receptor and can be radioiodinated. Also provided are methods of making such peptide ligands and methods of using the ligands for diagnostic and therapeutic uses and for the identification of other naturally-occurring or synthetic opioid receptor ligands.
|Issued||United States||6,406,866 B1|
- OHSU # 0349 — Opioid Antagonists and Methods of Their Use (Orphanin & analogs)
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Technology Development Manager