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A Chemical Genetic Approach for Identifying Family-member Specific Targets of MonoPARPs

 

OHSU # 2162

Technology Overview:

Poly-(ADP-ribose) polymerases (PARPs) are emerging as critical regulators of cell function in both normal physiology and disease, particularly neurodegeneration and cancer. These enzymes transfer the ADP-ribose moiety from its substrate, nicotinamide adenine dinucleotide (NAD+), to amino acids of target proteins. Mono-PARPs, also known as mono-ADP-rybosyltransferases (mono-ARTDs), catalyze the transfer of a single unit of ADP-ribose from NAD+ to target proteins. The cellular functions of mono-ADP-ribosylation are not nearly as well understood as they are for poly-ADP-ribosylation, which is due in part to the lack of available chemical tools to study mono-PARPs. Researchers at Oregon Health & Science University have developed a strategy to identify direct protein targets of specific mono-PARPs. This novel method is expected to significantly advance our understanding of the cellular functions of mono-PARPs.

 

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PublishedUnited StatesUS-2017-0146517

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