Bacterial artificial chromosome (BAC) clone containing the genome of human cytomegalovirus (HCMV) TR strain
OHSU # 1222
The TR BAC was prepared from the TR clinical HCMV isolate. This virus is resistant to ganciclovir and cidofovir and lacks UL97 codons 591-594. The BAC clone was generated by substituting BAC DNA for the US2-US5 region of the TR genome. The TR strain infects almost any diploid endothelial or epithelial cell as well as macrophages. This strain is useful for studies on HCMV including genetic studies.
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14976-81 "Coding potential of laboratory and clinical strains of human cytomegalovirus"
Dr. Jay Nelson joined the Oregon Health & Science University as a Professor in the Department of Molecular Microbiology and Immunology in 1992. He was also the Head of Pathobiology and Immunology at the Oregon National Primate Research Center from 1998 to 2000. He is currently the Director of the Vaccine and Gene Therapy Institute and holds joint appointments at the Oregon National Primate Research Center and the Department of Molecular Microbiology and Immunology.
Dr. Michael Jarvis received his MS (1995) and Ph.D. (1996) in Biochemistry and Molecular Biology from the University of California at Davis in the laboratory of Dr. J. S. Powell. After conducting his postdoctoral studies under the guidance of Dr. J. A. Nelson, Dr. Jarvis accepted a position as an Assistant Scientist with OHSU at the Vaccine and Gene Therapy Institute in January of 2002.
OHSU 1222 is currently available for non-exclusive licensing as a research tool.
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