Yeast expressing human VDAC isoforms
OHSU # 1124
- Biological Materials - Receptors/Targets
- Biological Materials - Protein/Peptides
- Biological Materials
The voltage dependent anion channel (VDAC) proteins are the major pathways for metabolite flux through the outer membrane. These mitochondrial membrane proteins control the flux of anions through voltage gated mechanisms. VDACs have been shown to be important in apoptotic responses and linked to certain neurodegenerative diseases.
In order to study Human voltage dependent anion channels (HVDACs) these investigators have developed yeast strains expressing HVDAC1 and HVDAC2. These strains can be used for screening small molecules against the HVDACs in an in vitro manner.
Michael Forte is a senior scientist at the Vollum Institute and a professor in the Departments of Molecular and Medical Genetics, Cell and Developmental Biology, and Physiology and Pharmacology in the School of Medicine at Oregon Health and Science University.
Elizabeth Blachly-Dyson is a Senior Research Associate at the Vollum Institute of Oregon Health and Science University.
J Biol Chem. 1993 Jan 25;268(3):1835-41 Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.
Genomics. 1994 Mar 1;20(1):62-7 Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms.
- OHSU # 1124-A — Yeast strain expressing human VDAC1
- OHSU # 1124-B — Yeast strain expressing human VDAC2
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