A Novel Adenosine Receptor (A3) and Uses
OHSU # 0223
- Research Tools - Screening
- Biological Materials - Receptors/Targets
- Biological Materials
- Research Tools
Technology 0223 relates to a novel mammalian adenosine receptor. The invention is directed toward the isolation, characterization and pharmacological use of the rat A3 adenosine receptor, the gene corresponding to this receptor, recombinant eudaryotic expression construct capable of expressing the rat A3 adenosine receptor in cultures of transformed eukaryotic cells that synthesize the rat A3 adenosine receptor.
The invention also provides methods for screening adenosine-receptor agonists and antagonists in vitro using preparations of the rat A3 adenosine receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the rat A3 adenosine receptor gene.
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