Categories | Inventors

Mouse Melanotroph Cell Line (MILtsA58) and cDNA Library Derived from the Cell Line

 

OHSU # 0523

Technology Overview:

Mouse Melanotroph Cell Line (MILtsA58) and cDNA Library Derived from the Cell Line

Mouse Melanotroph cell line (MILtsA58) is an immortalized cell line derived from an intermediate lobe melanotroph pituitary tumor induced by SV40ts A59 large T antigen in a transgenic mouse.  The cell line expresses POMC and at least 3 G protein-couples receptors normally found on melanotrophs and dopamine D2 receptor, CRHR1 receptor, and GAβAβ receptor (both subunits).  The resulting cDNA library  was derived from the cell line.  The cell line and cDNA library are available from OHSU via the Office Technology Transfer and Business Development, techmgmt@ohsu.edu.

 

Relevant reference: Chronwall B.M., Davis T.D., Severidt M.W., Wolfe S.E., McCarson K.E., Beatty D.M., Low M.J., Morris S.J., Enna S.J. (2001) Constitutive expression of functional GABAB receptors in mIL-tsA58 cells requires both GABAB(1) and GABAB(2) genes. J. Neurosci, 77:1237-1247 

Inventors:

Categories:

For more information, contact:

Michele Gunness
Senior Technology Development Manager
503-494-4184