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Novel Biosensor for Direct Measurement of Bioavailable NAD+

 

OHSU # 1988

Technology Overview:

This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the misregulation of NAD+ metabolism and homeostasis.

 

NAD+ serves dual roles as both an intermediary metabolite and as a required co-substrate for Sirtuin and PARP enzymes, and thus is positioned centrally in a number of biological processes. However, techniques to dynamically monitor free NAD+ in live cells or specific subcellular organelles has eluded the research community. This has had tremendous impact on the development of novel therapies. NAD+ exists in distinct intracellular pools, each compartmentalized and whose concentrations are under local control.  To overcome this limitation, researchers at Oregon Health & Science University developed a genetically-encoded fluorescent biosensor for direct measurement of the bioavailable NAD+ levels in specific cellular compartments.

 

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Travis Cook
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503-494-3229