Real-Time Non-Invasive Tracking of Moving Lung Tumors in Radiation Therapy of Lung Cancer
OHSU # 0997
Respiratory motion in the thorax and abdomen limit our ability to deliver radiation accurately and effectively during radiation treatment of lung tumors. The goal, therefore, was to develop technology to enable effective and accurate management of respiratory motion for radiation therapy of lung cancer using noninvasive sensory means and advanced statistical signal processing techniques.
Using a mixture of non-invasive imaging sensors already on the market and proven statistical modeling and estimation techniques, Dr. Song is recruiting volunteer subjects, pilot data collection, preprocessing to form a database for model/algorithm design. The benefits can enable continuous non-fragmented delivery of radiation.
• Lung cancer accounts for 30% of all cancer fatalities [American Cancer Society, 2004].
• Currently, there are 170,000 diagnoses per year
• Patients are given a 5-year relative survival rate of 15% - only marginally better than 25 years ago.
Better accuracy, efficacy and less toxicity than current methods for treating lung cancer.
Can make radiation a viable option for some patients, who otherwise cannot withstand the discomfort and toxicity of conventional radiation due to their severely compromised lung function.
Can be applied to the treatment of other abdominal tumors affected by motion (liver, pancreas kidney etc.)
Several methods used in radiation treatment of lung tumors are currently on the market:
Elekta Active Breathing Coordinator, which requires a patient to hold their breath during cycles of treatment.
Varian’s RPM System also uses a technique of respiratory gating. Accuray’s Cyberknife, Synchrony System for Adaptive Radiotherapy and the
general method of abdominal compression.
However, the limitations of the above methods include patient discomfort, low accuracy, fragmented treatment cycle, and invasive procedures.
- Xubo Song, SM.Science & Engineering
- Deniz Erdogmus, SM.Biomedical Engineering
- Mark Deffebach, SM.Medicine
- Darryl Kaurin, SM.Radiation Medicine
- John Holland, SM.Radiation Medicine
- John Fitchen, SM.Medicine
- Jeff Eriksen
- Martin Fuss, SM.Diagnostic Radiology
|Published||Patent Cooperation Treaty||WO 2009-042637-A2|
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Technology Development Manager