CyP-D Knock-Out Mice
OHSU # 0959
Cyclophilin D (Cyp-D), also known as CyP-F in mice, is a member of the larger cyclophilin family and is equivalent to the previously cloned cDNA encoding human CyP-3. Mice have been generated in which the gene encoding mitochondrial cyclophilin (CyP-D or Ppif) has been eliminated by knockout strategies.
These animals and their cells can be used to test the in vivo role of the mitochondrial permeability transition in various pathological responses of relevance to human disease; specifically, models of ischemia/reperfusion injury in heart and brain and neurodegenerative processes.
The mice continue to be utilized to examine the role of Cyclophilin-D in biological systems.
J Biol Chem. 2005 May 13;280(19):18558-61 "Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D"
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