Biochemical Stabilization of Glucagon
OHSU # 1815
Glucagon formulation for closed-loop Type 1 diabetes management systems
A proprietary, stable formulation of glucagon has been developed at OHSU for use in closed loop glycemic management systems comprising sensors and pumps. Ideally, small doses of glucagon need to be kept in a portable pump for 3 days at room temperature to body temperature for subcutaneous delivery. The major problem that prevents this use is glucagon’s chemical instability after its reconstitution – it aggregates and degrades. In solution, glucagon is highly unstable, and must be reconstituted often for the closed loop application. OHSU researchers have solved this problem with a more stable formulation of glucagon suitable for use in closed loop glycemic management systems.
US Provisional patent application filed
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Senior Technology Development Manager