Kim Dupree Jones, Ph.D.

"My program of research is to develop and test treatments to improve fibromyalgia symptoms. The core symptom of fibromyalgia is chronic widespread pain. The pain is usually perceived as arising from muscle, however many fibromyalgia patients also report joint pain. Stiffness, worse in the early morning, along with the perception of articular pain, may reinforce the impression of an arthritic condition. Fibromyalgia pain and stiffness typically have a diurnal variation, with a nadir during the hours of about 11 a.m. to 3 p.m. Symptoms also wax and wane in intensity over days and weeks; with flares occurring with increased exertion, systemic infections, soft tissue injuries, lack of sleep, cold exposure, restless leg syndrome, bruxism, irritable bowel and bladder and psychological stressors. With this debilitating list of symptoms, it is not surprising that obesity and physical deconditioning are common comorbidities. Additionally, women are disproportionately affected (9:1). Therefore the field is ripe for investigation related to gender discrimination.

I am fortunate to work with a world-renowned interdisciplinary team of nurse scientists, physicians, psychologists, methodologists, and physical and occupational therapist. We developed a 10,000 patient database and maintain an active clinical practice in which I see patients as a family nurse practitioner. The team has over 30 years of scholarly investigation and publications. Many are considered thought leaders in the field. Notably, the Oregon team helped determine the American College of Rheumatology 1990 classification criteria, developed the primary outcome questionnaire for fibromyalgia research and described perturbations in the GH/IGF-1 axis. We conduct randomized controlled clinical trials funded by the National Institutes of Health, foundations and industry. At the current time, we are conducting exercise and drug treatment interventions as well as acute dosing and descriptive studies.

We are actively seeking collaborators, co-investigators, Ph.D. students, and post-doctoral and rheumatology fellows. We are also committed to creating a productive and scholarly learning environment and continue to grow and diversify our team. If you are interested in joining our team, please contact my project director, Ann Reiner R.N., M.S., Ph.D. Candidate, at 503 494-3811. You are invited to our bimonthly team meetings. We hope you will join us in our fight to legitimize the diagnosis, find effective treatments to manage symptoms, improve functional ability and maximize quality of life."

TEACHING

9/1996-present
Assistant Professor or Graduate Teaching Assistant, Primary Health Care Nurse Practitioner Programs OHSU, School of Nursing WebMD (Medical Expert, Fibromyalgia Message Boards) http://boards.webmd.com

8/2002-present
Assistant Professor (research), School of Medicine, OHSU Medical Director-OHSU Health Systems Management, Nurse Practitioner, Rheumatology Clinic OHSU

RESEARCH

Pending Research Support

Optimizing growth hormone release in fibromyalgia patients. Under review as new R01 NIH/NIAMS
Jones (PI)

Tai Chi versus Stretching in Fibromyalgia- Jones-Consultant, Under Review as R01 application to NIAMS. Oregon Research Institute- Fisher (PI)

Objective Markers of Pain in Fibromyalgia: Nociceptive Reflex Testing and PET Scanning. National Fibromyalgia Research Association.

Ongoing Research Support

Growth Hormone Response to Growth Hormone Releasing Hormone and Pyridostigmine in Fibromyalgia
Deodhar, PI. Jones Co-Investigator
Gerlinger Award OHSU, Additional industry support from Serono and Valeant Pharmaceuticals

Prevalence of Fabry Disease in a Fibromyalgia Clinic. Steiner, R. (PI) Jones, Co-I. (donated)
Funded through Transkaryotic Therapies, makers of Replagal™, the current genetic treatment for Fabry.

CT versus MRI scanning in Fibromyalgia. (PI) Purnell. Co-Investigator Jones (donated)
OHSU GCRC and SON funded.
The purpose of this study is two fold- 1) compare gold-standard CT scanning to faster, lower radiation scanning of MRI, and 2) determine if people with fibromyalgia has a disproportionate amount of abdominal fat distribution compared to matched controls.

Discerning Research Direction and Priorities in Fibromyalgia PI-Nelson, Co-investigator U award through NIAMS.
The purpose of this meeting is to set research priorities for NIAMS for fibromyalgia.

Bone Mineral Density and Abdominal Adiposity in Fibromyalgia, PI (donated)
OHSU School of Nursing Funded.
The goal of this study is to determine whether the drug and exercise R01 described below also impact bone density and fat distribution. Winters Co-investigator

1 R01 NR008150-01
Maximizing Exercise Benefit in Fibromyalgia, Jones (PI) 7/01/02-6/30/06
NIH/NINR
The goal of this project is the test the hypothesis that people with fibromyalgia whose insulin-like growth factor axis have been pharmacologically manipulated and participate in training exercise will achieve better symptom relief than either intervention alone.

1P20NR07807
(Symptom Management in Life-Threatening Illness, Nail (PI)) 9/1/2001-8/30/04
Pain Similarities in Breast Cancer and Fibromyalgia, Burckhardt (PI) and for pilot NIH/NINR for center
The goal of this project is to describe chronic pain pathways in women with fibromyalgia and in women with chronic pain post mastectomy, using a variety of measures including a TSA-II NeuroSensory Analyzer. Currently in non-funded continuation. Recruitment and testing completed. Data analysis underway.

SELECTED PEER-REVIEWED PUBLICATIONS

Jones, K.D. & Burckhardt, C.S. (1997) “Multidisciplinary treatment innovations for fibromyalgia syndrome, Amer J for Nurse Practitioners,1(4):7-14 & 32.

Burckhardt, C., Jones, K.D. & Clark, S. (1998), “Soft tissue rheumatic disease problems, Lippincott Primary Care Practice, 2(1): 20-29.

Jones, K.D. & Clark, S.R. (1998) “Fitting in Fitness” Nurseweek 11(1):12-17. Reprinted in Healthweek,3(2):18-21.

Jones, K.D. & Tilden, V.P. (1998). “Authorship issues in multidisciplinary research teams,” Am J Nurs Practitioners, 2(5): 18-25 & 34.

Demi, A., Jones, K.D., & Brown, J. (1998). "Home-based nursing intervention program for young children with asthma: A pilot study" American Journal for Nurse Practitioners, 2(10): 15-30.

Jones, K.D. & Lutz, K. (1999). "Selecting Doctoral Programs in Nursing: Resources for Faculty and Students’ J of Professional Nursing, 15(4): 245-252.

Burckhardt, C. & Jones, K.D. (2000). “Understanding fibromyalgia”, Nurseweek Multidisciplinary CE Anthology, 175-198.

Jones, K.D. & Clark, S.R. (2000). “Promoting Physical Activity,” Nurseweek Multidisciplinary CE Anthology, 199-205.

Clark, S., Jones, K., Burckhardt, C.S., Bennett, R.M., (2001). “Exercise for patients with fibromyalgia: Risks versus benefits.” Current Rheumatology Reports. 3(2): 135-40.

Jones, K.D., Burckhardt, C.S., Clark, S., Bennett, R.M. (2001). Muscle Strengthening Versus Flexibility Training in Fibromyalgia: One Year Follow-up of a Randomized Controlled Study. American College of Rheumatology Annual Meeting/Abstract #250134.

Hoffman, J. & Jones, K.D. (2002). Reducing attrition from exercise classes: Practical tips from research. American College of Sports Medicines’ Health & Fitness Journal, 6 (2), 7-10 & 36-7.

Jones, K.D., Burckhardt, C.S., Clark, S., Bennett, R.M. & Potempa, K. (2002). A randomized controlled trial of muscle strengthening versus flexibility training in fibromyalgia. J of Rheumatology, 29, 1041-8.

Paiva, E.S., Bennett, R.M., Deodar, A., & Jones, K. D. Impaired Growth Hormone Secretion in Fibromyalgia Patients: Evidence for Augmented Hypothalamic Somatostatin Tone (2002). Arthritis and Rheum, 46 (5), 1344-50.

Jones, K.D., Clark, S., & Bennett, R.M. (2002). Prescribing exercise for people with fibromyalgia. AACN Clinical Issues, 13 (2), 277-293.

Jones, K.D. & Clark, S.R. (2002). Individualizing the exercise prescription for persons with fibromyalgia. Rheumatic Disease Clinics of North America, 28, 419-436.

Burckhardt, C.S. & Jones, K.D. (2003). Adult measures of pain: The McGill Pain Questionnaire (MPQ), Rheumatoid Arthritis Pain Scale (RAPS), Short-Form McGill Pain Questionnaire (SF-MPQ), Verbal Descriptive Scale (VDS), Visual Analog Scale (VAS), and West Haven-Yale Multidisciplinary Pain Inventory (WHYMPI) (p S96-S104) Arthritis Care & Research 49:5S, S96-S104

Jones, K.D., Bennett, R.M., Burckhardt, C.S., Deodhar, A., & Perrin, N. (2004). Maximizing exercise effectiveness in fibromyalgia: Year one data (Abstract). Western Institute of Nursing Research, Portland, OR.

Jones, K.D., Bennett, R.M., Burckhardt, C.S., Deodhar, A., & Perrin, N. (2004). A randomized controlled trial of chronic pyridostigmine bromide and exercise. Defining the Neurological Basis of Fibromyalgia. Fifth International Conference of the National Fibromyalgia Research Association, Portland, Or, Published abstract.

Jones, K.D., Burckhardt, C.S. & Bennett, J.A, (2004). Motivational Interviewing May Encourage Exercise in Persons with Fibromyalgia by Enhancing Self-efficacy. Arthritis Care and Research, 51(5), 864 – 867.

Jones, K.D., Bennett, R.M., Burckhardt, C.S., Deodhar, A.A., & Perrin, N.A. (2004). Improving growth hormone secretion in fibromyalgia: Response to pyridostigmine and exercise. J of Musculoskeletal Pain, 12(9), 55.

Jones, K.D., Bennett, R.M., Burckhardt, C.S., Deodhar, A., & Perrin, N. (2004). A randomized controlled trial of chronic pyridostigmine bromide and exercise in fibromyalgia: preliminary analysis of time two data. American College of Rheumatology, 68th Annual Scientific Meeting, San Antonio, TX, Oct. 20, 2004. Abstract # 1258.

Jones, K.D. (2004). Current and future use of growth hormone secretogogues in clinical practice in fibromyalgia: research underpinnings. 53rd Annual Meeting of Internal Medicine Physicians. Portland, OR, Published abstract.

Jones, K.D., Bennett, RM, Burckhardt, C, Deodhar, A. & Perrin, N. (2004). Chronic Therapy with Exercise and Pyridostigmine Improves Growth Hormone Response to Exercise, Fatigue, Sleep Quality and Quality of Life in Fibromyalgia: Preliminary Intent to Treat Analyses. Fibromyalgia Workshop: The Next Advances. Abstract accepted for U award through NIAMS (Nelson, D PI). Washington, DC.

Jones, K.D., Winters, K. (in press). V02 peak measurement in graded exercise testing: Experiences from 167 treadmill tests in fibromyalgia. J of Musculoskeletal Pain.

FIBROMYALGIA RESOURCES

Visit Dr. Kim Jones' Fibromyalgia Resources Page