Welcome to the Department of Pediatrics Clinical Research home page.

Clinical research is an important component of the Department’s research activity. Currently, there are more than 80 active clinical trials and . This activity has steadily increased in recent years, and is expected to grow even further with the expansion of the Pediatric Clinical Research Office (PCRO). 

Amira Al-Uzri, M.D. PCRO Associate Director
Robert D. Steiner, M.D. PCRO Interim Director

Mission:
To facilitate the planning, design, coordination, performance, and tracking of clinical research in children according to local, federal, and international guidelines & laws.



Goals:

• Investigate the pharmacology of novel therapeutic agents in children
  
• Increase the overall quantity and quality of clinical trials and especially participation in NIH-sponsored trials at DCH (examples of how clinical trials can foster career development).
  
• Partner with OCTRI to develop translational research in pharmacogenomics and pharmacoproteomics 
  
• Collaborate with community pediatricians to conduct clinical research
  
• Provide a milieu for educating health professionals about pediatric clinical research and clinical trials 
  
• Attract inquiries for study participation from academic colleagues and industry partners
  
• Participate in creation of a Pediatric General Clinical Research Center (CTRC) as part of the CTSA grant (OCTRI)

• Coordinated 22 clinical trials in FY’06
  
• Recruited experienced study coordinators to the PCRO staff
  
• Coordinating studies in stem cell transplantation in adults & children
  
• Developing a database for the PCRO
  
• Increasing collaboration with adult investigators by conducting clinical trials involving children and young adults
  
• Increasing collaboration with the Clinical Trials Office (CTO) & GCRC (now CTRC)

• Defibrotide for the treatment of severe hepatic veno-occlusive disease in hematopoietic stem cell transplant patients (E. Nemecek)
  
• Evaluation of the safety, efficacy, and pharmacokinetics of micardis (telimisartan) in children and adolescents with hypertension after of four weeks of treatment (A. Al-Uzri)
  
• Pharmacokinetics & pharmacodynamics of 2 dose levels of Pantoprazol Sodium Enteric-Coated Spheriod Supension in infants 1 - 11 mths w/presumed GERD (Y. Eroglu)
  
• Phase 3 Trial to assess the safety of Tobracmycin Inhalation Powder (TIP) compared to TOBI in Cystic Fibrosis subjects (M. Wall).

Clinical research News

• New research beds at Doernbecher
• Update on the stem cell trial
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