Angiogenesis Research Laboratory

The Powers' lab uses a mouse model of retinopathy of prematurity (ROP) to investigate the balance between angiogenic cytokines and pro-apoptotic factors in retinal neovascularization. In vitro studies using retinal endothelial cells are used to study intracellular pathways of apoptosis. Our ongoing studies use ocular neovascularization as a valuable model system but our results will also shed light on the basic biological processes of pathological angiogenesis. Our studies have broad applicability to other disease such as diabetic retinopathy, asthma, heart disease, hemangiomas, as well as childhood cancer and metastasis. The laboratory is located on the 2nd floor of the Biomedical Research Building in the Casey Eye Institute Laboratories.