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Endodontic Classic Literature Review
Pulpal & Periapical Disease
Spring Quarter 2007

Objectives:

  • Describe the cells in the pulp and the periapex involved in specific immunological reactions and nonspecific inflammatory reactions
  • Understand the significance of these reactions in pulpal and periapical disease
  • Describe the reactions that are protective and the reactions that are pathogenic

* Read and abstract:

1.         Kennedy DR, Hamilton TR, Syverton JT. Effects on monkeys of introduction of hemolytic streptococci into root canals. J Dent Res. 1957;36:496-506.
2.         Linenberg WB, Waldron CA, DeLaune GF. A clinical, roentgenographic, and histopathologic evaluation of periapical lesions. Oral Surg. 1964;17(4):467-72.
3.         Barnes GW, Langeland K. Antibody formation in primates following introduction of antigens into the root canal. J Dent Res. 1966;45:1111-4.
4.         Lalonde ER, Luebke RG. The frequency and distribution of periapical cysts and granulomas. Oral Surg. 1968;25(6):861-8.
5.         Kuntz DD, Genco RJ, Guttusco J, Natiella JR. Localization of immunoglobulins and the third component of complement in dental periapical lesions. J Endodon. 1977;3(2):68-73.
6.         Morton TH, Clagett JA, Yavorsky JD. Role of immune complexes in human periapical periodontitis. J Endodon. 1977;3(7):261-8.
7.         Bergenholtz Z, Ahlstedt S, Lindhe J. Experimental pulpitis in immunized monkeys. Sand J Dent Res. 1977;85:396.
8.         Sveen K. The capacity of lipopolysaccharides from bacteroides, fusobacterium and veillonella to produce skin inflammation and the local and generalized Shwartzman reaction in rabbits. J Periodont Res. 1977;12:340-50.
9.         Pulver WH, Taubman MA, Smith DJ. Immune components in human dental periapical lesions. Arch Oral Biol. 1978;23:435-43.
10.       Torabinejad M, Kettering JD, Bakland LK. Evaluation of systemic immunological reactions to AH-26 root canal sealer. J Endodon. 1979;5(7):196-200.
11.       Stuart WW, Crowley LV, Turner DW, Pelleu GB, Jr., Osetek EM. Humoral response to endodontic cements. J Endodon. 1979;5(7):214-7.
12.       Jones OJ, Lally ET. Biosynthesis of immunoglobulin isotypes in human periapical lesions. J Endodon. 1980;6(8):672-7.
13.       Dwyer TG, Torabinejad M. Radiographic and histologic evaluation of the effect of endotoxin on the periapical tissues of the cat. J Endodon. 1981;7(1):31-5.
14.       Stern MH, Dreizen S, Mackler BF, Selbst AG, Levy BM. Quantitative analysis of cellular composition of human periapical granuloma. J Endodon. 1981;7:117-22.
15.       Stern HM, Dreizen S, Makler BF, Levy BM. Antibody-producing cells in human periapical granulomas and cysts. J  Endodon. 1981;7(10):447-52.
16.       Pitts DL, Williams BL, Morton TH. Investigation of the role of endotoxin in periapical inflammation. J Endodon. 1982;8(1):10-8.
17.       Schoenfeld SE, Greening AB, Glick DH, Frank AL, Simon JH, Herles SM. Endotoxic activity in periapical lesions. Oral Surg. 1982;53(1):82-7.
18.       Dahlén G, Fabricius L, Holm SE, Möller ÅJR. Circulating antibodies after experimental chronic infection in the root canal of teeth in monkeys. Scand J Dent Res. 1982;90:338-44.
19.       Dahlén G, Fabricius L, Heyden G, Holm SE, Möller ÅJR. Apical periodontitis induced by selected bacterial strains in root canals of immunized and nonimmunized monkeys. Scand J Dent Res. 1982;90:207-16.
20.       Sundqvist G, Bloom GD, Enberg K, Johansson E. Phagocytosis of Bacteroides melaninogenicus  and Bacteroides gingivalis in vitro  by human neutrophils. J Periodont Res. 1982;17:113-21.
21.       Schonfeld SE, Greening AB, Glick DH, Frank AL, Simon JH, Herles SM. Endotoxic activity in periapical lesions. Oral Surg. 1982;53:82-7.
22.       Wilk AE, Milobsky S, Reynolds D, Princiotto J, Zapolski EJ. The demonstration of alpha1 antitrypsin in periapial lesions. Oral Surg. 1983;86-90.
23.       Svetcov SD, DeAngelo JE, McNamara T, Nevins AJ. Serum immunoglobulin levels and bacterial flora in subjects with acute oro-facial swellings. J Endodon. 1983;9(6):233-5.
24.       Torabinejad M, Theofilopoulos AN, Ketering JD, Bakland LK. Quantitation of circulating immune complexes, immunoglobulins G and M, and C3 complement component in patients with large periapical lesions. Oral Surg. 1983;55:186-90.
25.       Johannessen A. Deposits of immunoglobulins and complement factor C3 in human dental periapical inflammatory lesions. Scand J Dent Res. 1983;91:191.
26.       Cymerman JJ, Cymerman DH, Walters J, Nevins AJ. Human T lymphocyte subpopulations in chronic periapical lesions. J Endodon. 1984;10(1):9-11.
27.       Kettering JD, Torabinejad M. Concentrations of immune complexes, lgG, IgM,  IgE, and C3 in patients with acute apical abscesses. J Endodon. 1984;10(9):417-21.
28.       Johannessen AC, Nilsen R, Skaug N. Enzyme histochemical characterization of mononuclear cells in human dental periapical chronic inflammatory lesions. Scand J Dent Res. 1984;92:325-33.
29.       Nilson R, Johannessen AC, Skaug N, Matre R. In situ characterization of mononuclear cells in human dental periapical inflammatory lesions using monoclonal antibodies. Oral Surg. 1984;58:160-5.
30.       Torabinejad M, Kettering JD. Identification and relative concentration of B and T lymphocytes in human chronic periapical lesions. J Endodon. 1985;11(3):122-5.
31.       Perrini N, Fonzi L. Mast cells in human periapical lesions: ultrastructural aspects and their posssible physiopathological implications. J Endodon. 1985;11(5):197-202.
32.       Nevins AJ, Levine S, Faitlowicz-Gayer Y, Svetcov S. Sensitization via lgE-mediated mechanism in patients with chronic periapical lesions. J Endodon. 1985;11(5):228-30.
33.       Torabinejad M, Eby WC, Naidorf IJ. Inflammatory and immunological aspects of the pathogenesis of human periapical lesions. J Endodon. 1985;11(11):479-88.
34.       Callis PD, Santini A. A suggested role for polymorphonuclear leukocytes in the perpetuation of periapical disease. Oral Surg. 1985;59(1):88-90.
35.       Van Steenbergen TJM, Namavar F, De Graaff J. Chemiluninescence of human leukocytes by black-pigmented Bacteroides strains from dental plaque and other sites. J Peridont Res. 1985;20:58-71.
36.       Shinoda A, Murayama Y, Okada H. Immunopathological role of pulpal tissue components in periapical pathosis.  II. specifications of antigenic determinants on modified serum albumins. J Endodon. 1986;12(11):528-33.
37.       White RK, Montgomery S. Leukotrienes: Inflammatory mediators-A review. Oral Surg. 1986;61(5):514-8.
38.       Nilsen MF, Finlay-Jones JJ. T-lymphocyte involvement in abscess formation in nonimmune mice. Infec Immun. 1986;52:633-6.
39.       Negm MM, Sherif SH. Biologic evaluation of SPAD. Oral Surg. 1987;63(4):478-86.
40.       Contos JG, Corcoran JF, Jr., LaTurno SAL, Chiego DJ, Regezi JA. Langerhans cells in apical periodontal cysts:  an immunohistochemical study. J Endodon. 1987;13(2):52-5.
41.       Gerner NW, Hurlen B, Doblong J, Brandtzaeg P. Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. Endod Dent Traumatol. 1988;4(3):127-31.
42.       Serene TP, Vesely J, Boackle RJ. Complement activation as a possible in vitro indication of the inflammatory potential of endodontic materials. Oral Surg. 1988;65(3):354.
43.       Barkhordar RA, Desousa YG. Human T-lymphocyte subpopulations in periapical lesions. Oral Surg. 1988;65:763-6.
44.       Kopp W, Schwarting R. Differentiation of T lymphocyte subpopulations, macrophages, and HLA-DR-restricted cells of apical granulation tissue. J Endodon. 1989;15(2):72-5.
45.       Horiba N, Maekawa Y, Matsumoto T, Nakamura H. A study of the distribution of endotoxin in the dentinal wall of infected root canals. J Endodon. 1990;16(7):331-4.
46.       Lukic A, Arsenijevic N, Vujanic G, Ramic Z. Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. J Endodon. 1990;16(3):119-22.
47.       Kettering JD, Torabinejad M, Jones SL. Specificity of antibodies present in human periapical lesions. J Endodon. 1991;17(5):213-6.
48.       Baumgartner JC, Falkler WA, Jr. Biosynthesis of IgG in periapical lesion explant cultures. J Endod. 1991;17(4):143-6.
49.       Safavi KE, Rossomando EF. Tumor necrosis factor identified in periapical tissue exudates of teeth with apical periodontitis. J Endodon. 1991;17(1):12-4.
50.       Piattelli A, Artese L, Rosini S, Quaranta M, Musiani P. Immune cells in periapical granuloma: morphological and immunohistochemical characterization. J Endodon. 1991;17(1):26-9.
51.       Baumgartner JC. Microbiologic and pathologic aspects of endodontics. Current Opinion in Dentistry. 1991;1(6):737-43.
52.       Bergenholtz G, Nagaoka S, Jontell M. Class II antigen expressing cells in experimentally induced pulpitis. Int Endod J. 1991;24:8-14.
53.       Baumgartner JC, Falkler WA, Jr. Detection of immunoglobulins from explant cultures of periapical lesions. J Endod. 1991;17(3):105-10.
54.       Baumgartner JC, Falkler WA. Reactivity of IgG from explant cultures of periapical lesions with implicated microorganisms. J Endod. 1991;17:207-12.
55.       Eftimiadi C, Stashenko P, Tonetti M, Mangiante PE, Massara R, Zupo S, et al. Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response:  suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production. Oral Microbiol Immunol. 1991;6:17-23.
56.       Horiba N, Maekawa Y, Abe Y, Ito M, Matsumoto T, Nakamura H. Correlations between endotoxin and clinical symptoms or radiolucent areas in infected root canals. Oral Surg. 1991;71:492-5.
57.       Baumgartner JC, Falkler WAJ. Serum IgG reactive with bacteria implicated in infections of endodontic origin. Oral Micro and Immun. 1992;7:106-10.
58.       Akamine A, Anan H, Hamachi T, Maeda K. A histochemical study of the behavior of macrophages during experimental apical periodontitis in rats. J Endodon. 1994;20(10):474-8.
59.       Lerner UH. Regulation of bone metabolism by the kallikrein-kinin system, the coagulation cascade, and the acute-phase reactants. Oral Surg. 1994;78(4):481-93.
60.       Torabinejad M. Mediators of acute and chronic periradicular lesions. Oral Surg. 1994;78(4):511-23.
61.       Ahlquist ML, Franzen OG. Inflammation and dental pain in man. Endod Dent Traumatol. 1994;10(5):201-9.
62.       Rauschenberger CR, McClanahan SB, Pederson ED, Turner DW, Kaminski EJ. Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-g, and (alpha)2-macroglobulin levels in healthy and inflamed dental pulps. J Endodon. 1994;20(11):546-50.
63.       Hamachi T, Anan H, Akamine A, Fujise O, Maeda K. Detection of interleukin-1B mRNA in rat periapical lesions. J Endodon. 1995;21(3):118-21.
64.       Harrison JW, Roda RS. Intermediate cementum. Oral Surg. 1995;79(5):624-33.
65.       Caliskan MK, Sen BH, Ozinel MA. Treatment of extraoral sinus tracts from traumatized teeth with apical periodontitis. Endod Dent Traumatol. 1995(11):115-20.
66.       Schachman MA, Rosenberg PA, Linke HAB. Quantitation of catecholamines in uninflamed human dental pulp tissues by high-performance liquid chromatography. Oral Surg. 1995;80(1):83-6.
67.       Ehnevid H, Jansson L, Lindskog S, Weintraub A, Blomlof L. Endodontic pathogens: propagation of infection through patent dentinal tubules in traumatized monkey teeth. Endod Dent Traumatol. 1995;11(5):229-34.
68.       Peters LB, Wesselink PR, Moorer WR. The fate and role of bacteria left in root dentinal tubules. Int Endodon J. 1995;28:95-9.
69.       Tani-Ishi N, Kuchiba K, Osada T, Watanabe Y, Umemoto T. Effect of T-cell deficiency on the formation of periapical lesions in mice: histological comparison between periapical lesion formation in BALB/c and BALB/c nu/nu  mice. J Endodon. 1995;21(4):195-9.
70.       Tamura M, Nagaoka S, Kawagoe M. Interleukin-1 stimulates interstitial collagenase gene expression in human dental pulp fibroblast. J Endodon. 1996;22(5):240-3.
71.       Mah R, Holland GR, Pehowich E. Periapical changes after orthodontic movement of root-filled ferret canines. J Endodon. 1996;22(6):298-303.
72.       Lin LM, Wang SL, Wu-Wang C, Chang KM, Leung C. Detection of epidermal growth factor receptor in inflammatory periapical lesions. Int Endod J. 1996;29:179-84.
73.       Kawashima N, Okiji T, Kosaka T, Suda H. Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: a quantitative immunohistochemical study. J Endodon. 1996;22(6):311-6.
74.       Komorowski RC, Torneck CD, Hu JW. Neurogenic inflammation and tooth pulp innervation pattern in sympathectomized rats. J Endodon. 1996;22(8):414-7.
75.       Miller GA, DeMayo T, Hutter JW. Production of interleukin-1 by polymorphonuclear leukocytes resident in periradicular tissue. J Endodon. 1996;22(7):346-51.
76.       Hamamoto Y, Nakajima T, Ozawa H, Uchida T. Production of amelogenin by enamel epithelium of hertwig's root sheath. Oral Surg. 1996;81(6):703-9.
77.       Lin LM, Gaengler P, Langeland K. Periradicular curettage. Int Endod J. 1996;29:220-7.
78.       Lomcali G, Sen BH, Cankaya H. Scanning electron microscopic observations of apical root fractures of teeth with apical periodontitis. Endod Dent Traumatol. 1996;12:70-6.
79.       Piattelli A. Ossifying fibroma as a mixed radiolucent-radiopaque periapical lesion. J Endodon. 1996;22(3):145-6.
80.       Ribera MJ. Osteoblastoma in the anterior maxilla mimicking periapical pathosis of odontogenic origin. J Endodon. 1996;22(3):142-4.
81.       Miyauchi M, Takata T, Ito H, Ogawa I, Kobayashi J, Nikai H, et al. Immunohistochemical demonstration of prostaglandins E2, F2, and 6-keto-prostaglandin F1 in rat dental pulp with experimentally induced inflammation. J Endodon. 1996;22(11):600-2.
82.       Takayama S, Miki Y, Shimauchi H, Okada H. Relationship between prostaglandin E2concentrations in periapical exudates from root canals and clinical findings of periapical periodontitis. J Endodon. 1996;22(12):677-80.
83.       Wiebkin OW, Cardaci SC, Heithersay GS, Pierce AM. Therapeutic delivery of calcitonin to inhibit external inflammatory root resorption II. Influence of calcitonin binding to root mineral. Endod Dent Traumatol. 1996;12:272-6.
84.       Hollinger J, Wong MEK. The integrated processes of hard tissue regenertation with special emphasis on fracture healing. Oral Surg. 1996;82(6):594-606.
85.       Wong MEK, Hollinger JO, Pinero GJ. Integrated processes responsible for soft tissue healing. Oral Surg. 1996;82(5):475-92.
86.       Meghji S, Qureshi W, Henderson B, Harris M. The role of endotoxin and cytokines in the pathogenesis of odontogenic cysts. Arch Oral Bio. 1996;41(6):523-31.
87.       Ninomiya J, Nakanishi K, Takemoto T, Higashi T, Ogawa T, Kawaguchi H, et al. Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions. J Endodon. 1997;23(4):213-6.
88.       Takahashi K, MacDonald GD, Kinane DF. Detection of IgA subclasses and j chain mRNA bearing plasma cells in human dental periapical lesions by in situ hybridization. J Endodon. 1997;23(8):513-6.
89.       Metzger Z, Berg D, Dotan M. Fibroblast growth in vitro suppressed by LPS-activated machrophages.  Reversal of suppression by hydrocortisone. J Endodon. 1997;23(8):517-21.
90.       Delzangles B, Lefevre MLB, Forest N. Glycoproteins expression in apical pathologic tissues: clinical incidences. J Endodon. 1997;23(9):565-8.
91.       Shimauchi H, Takayama S, Miki Y, Okada H. The change of periapical exudate prostaglandin E2 levels during root canal treatment. J Endodon. 1997;23(12):755-8.
92.       Cury VCF, Sette PS, da Silva JV, de Araujo VC, Gomez RS. Immunohistochemical study of apical periodontal cysts. J Endodon. 1998;24(1):36-7.
93.       Shimauchi H, Takayama S, Imai-Tanaka T, Okada H. Balance of interleukin-1B and interleukin-1 receptor antagonist in human periapical lesions. J Endodon. 1998;24(2):116-9.
94.       Takeichi O, Saito I, Hayashi M, Tsurumachi T, Saito T. Production of human-inducible nitric oxide synthase in radicular cysts. J Endodon. 1998;24(3):157-60.
95.       Takahashi K, Lappin DF, MacDonald GD, Kinane DF. Relative distribution of plasma cells expressing immunoglobulin G subclass mRNA in human dental periapical lesions using in situ hybridization. J Endodon. 1998;24(3):164-7.
96.       Ikeda H, Suda H. Subjective sensation and objective neural discharges recorded from clinically nonvital and intact teeth. J Endodon. 1998;24(8):552-6.
97.       Stashenko P, Teles R, D'Souza R. Periapical inflammatory responses and their modulation. Crit Rev Oral Bio Med. 1998;9(4):498-521.
98.       Harn WM, Chen YHM, Yuan K, Chung CH, Huang PH. Calculus-like deposit at apex of tooth with refactory apical periodontitis. Endod Dent Traumatol. 1998;14:237-40.
99.       Matsushita K, Tajima T, Tomita K, Abeyama K, Maruyama I, Takada H, et al. Inflammatory cytokine production and specific antibody responses against possible causative bacteria in patients with multilesional periapical periodontitis. J Endodon. 1998;24(12):817-21.
100.     Matsumoto A, Anan H, Maeda K. An immunohistochemical study of the behavior of clees expressing interleukin-1a and interleukin-1B within experimentally induced periapical lesions in rats. J Endodon. 1998;24(12):811-6.
101.     Matsumoto A, Anan H, Maeda K. An immunohistochemical study of the behavior of cells expressing interleukin-1a and interleukin-1B within experimentally induced periapical lesions in rats. J Endodon. 1998;24(12):811-6.
102.     Eberhard J, Plagmann H-C. Changes in the periodontal membrane due to apical periodontitis. J Endodon. 1999;25(7):486-9.
103.     Takeichi O, Hayashi M, Tsurumachi T, Tomita T, Ogihara H, Ogiso B, et al. Inducible nitric oxide synthase activity by interferon-(gamma)-producing cells in human radicular cysts. Int Endod J. 1999;32(2):124-30.
104.     Nair PNR, Sjogren U, Figdor D, Sundqvist G. Persistent periapical radiolucencies of root-filled human teeth, failed endodontic treatments, and periapical scars. Oral Surg. 1999;87:617-27.
105.     Tyler LW, Matossian K, Todd R, Gallagher G, White R, Wong DTW. Eosinophil-derived transforming growth factors (TGF-(alpha) and TGF-(beta)1) in human periradicular lesions. J Endodon. 1999;25(9):619-24.
106.     Leonardi R, Lanteri E, Stivala F, Travali S. Immunolocalization of CD44 adhesion milecules in human periradicular lesions. Oral Surgery Oral Medicine Oral Pathology. 2000;89(4):480-5.
107.     Silver G, Simon J. Charcot-leyden crystals within a periapical lesion. J Endodon. 2000;26(11):679-81.
108.     Jaunberzins A, Gutmann JL, Witherspoon DE, Harper RP. TGF-B1 alone and in combination with calcium hydroxide is synergistic to TGF-B1 production by osteoblasts in vitro. Int Endod J. 2000;33:421-6.
109.     Danin J, Linder LE, Lundqvist G, Andersson L. Tumor necrosis factor-alpha and transforming growth factor-beta1 in chronic periapical lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:514-7.
110.     Tasman F, Dagdeviren A, Kendir B, Er N, Ataç A. Endothelial cell and stromal antigens in human periapical granulation tissue. J Endodon. 2000;26(2):81-4.
111.     Tasman F, Cehreli ZC, Ogan C, Etikan I. Surface tension of root canal irrigants. J Endodon. 2000;26(10):586-7.
112.     Leonardi R, Villari L, Caltabiano M, Travali S. Heat shock protein 27 expression in teh epithelium of periapical lesions. J Endodon. 2001;27(2):89-92.
113.     Zuolo ML, Toledo MS, Hogueira HE, Straus AH, Takahashi HK. Identification of GM3 as a marker of therapy-resistant periradicular  lesions. J Endodon. 2001;27(2):107-9.
114.     Khayat A, Vesal N, Rasti M. Analysis of arylsulfatases A and B, acid phosphatase, lactate dehydrogenase, and aspartate transaminase in chronic periapical lesions of endodontic origin. J Endodon. 2001;27(4):285-4.
115.     Piattelli A, Fioroni M, Santinelli A, Rubini C. p53 protein expression in odontogenic cysts. J Endodon. 2001;27(7):459-61.
116.     Huang GT-J, Do M, Wingard M, Park JS, Chugal N. Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice. Oral Surg. 2001;92(1):83-8.
117.     Shimauchi H, Tadayama S, Narikawa-Kiji M, Shimabukuro Y, Okada H. Production of interleukin-8 and nitric oxide in human periapical lesions. J Endodon. 2001;27(12):749-52.
118.     Harn W-M, Chen M-C, Chen Y-HM, Liu J-W, Chung C-H. Effect of occlusal trauma on healing of periapical pathoses: report of two cases. Int Endod J. 2001;34:554-61.
119.     Piattelli A, Iezzi G, Fioroni M, Santinelli A, Rubini C. Ki-67 expression in dentigerous cysts, unicystic ameloblastomas, and ameloblastomas arising from dental cysts. J Endodon. 2002;28(2):55-8.
120.     Piattelli A, Rubini C, Iezzi G, Fioroni M. CD1a-positive cells in odontogenic cysts. J Endodon. 2002;28(4):267-8.
121.     Shin S-J, Lee J-I, Baek S-H, Lim S-S. Tissue levels of matrix metalloproteinases in pulps and periapical lesions. J Endodon. 2002;28(4):313-5.
122.     Ataoglu T, Ungor M, Serpek B, Haliloglu S, Ataoglu T, Üngör M, et al. Interleukin-1ß and tumor necrosis factor-(alpha) levels in periapical exudates. Int Endod J. 2002;25:181-5.
123.     Metzger Z, Klein H, Klein A, Tagger M. Periapical lesion development in rats inhibited by dexamethasone. J Endodon. 2002;28(9):643-5.
124.     Ko HJ, Lim SSL. Production of macrophage inflammatory protein (MIP)-1(alpha) and MIP-1ß by human polymorphonuclear neutrophils stimulated with porphyromonas andodontalis lipoplysaccharide. J Endodon. 2002;28(11):754-7.
125.     Yang Y-Y, Tsai H-F, Lu S-C, Huang Y-F, Chang Y-C. Regualtion of tissue inhibitors of metalloproteinase-1 gene expression by cytokines in human gingival fibroblasts. J Endodon. 2002;28(12):803-5.
126.     Kum K-Y, Park J-H, Yoo Y-J, Choi B-K, Lee H-J, Lee S-J. The inhibitory effect of alendronate and taurine on osteoclast differentiation mediated by prophyromonas gingivalis sonicates in vitro. J Endodon. 2002;29(1):28-30.
127.     Piattelli A, Fioroni M, Iezzi G, Rubini C. Calretinin expression in odontogenic cysts. J Endodon. 2003;29(6):394-6.
128.     Leonardi R, Caltabiano M, Pagano M, Pezzuto V, Loreto C, Palestro G. Detection of vascular endothelial growth factor/vascular permeability factor in periapical lesions. J Endodon. 2003;29(3):180-3.
129.     Jiang J, Zuo J, Chen S-H, Holliday LS. Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(3):348-54.
130.     Liapatas S, Nakou M, Rontogianni D. Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study. Int Endod J. 2003;36:464-71.
131.     de Sá AR, Pimenta FJGS, Dutra WO, Gomez RS. Immunolocalization of interleukin 4, interleukin 6, and lymphotoxin a in dental granulomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(3):356-60.
132.     Danin J, Linder L, Lundqvist G, Wretlind B. Cytokines in periradicular lesions: the effect of linezolid treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:492-8.
133.     Barthel CR, Zimmer S, Trope M. Relationship of radiologic and histologic signs of inflammation in human root-filled teeth. J Endodon. 2004;30(2):75-9.
134.     Trasatti C, Spears R, Gutmann JL, Opperman LA. Increased Tgf-ß1 production by rat osteoblasts in the presence of PepGen P-15 in vitro. J Endodon. 2004;30(4):213-7.
135.     Tuncer LI, Alacam T, Oral B. Substance P expression is elevated in inflamed human periradicular tissue. J Endodon. 2004;30(5):329-32.
136.     Piatelli A, Rubini C, Fioroni M, Favero L. Expression of transforming growth factor-beta 1 (TGF-beta 1) in odontogenic cysts. Int Endod J. 2004;37:7-11.
137.     Kabashima H, Yoneda M, Nakamuta H, Nagata K, Isobe R, Motooka N, et al. Presence of CXCR3-positive cells and IFN-gamma-producing cells in human periapical granulomas. J Endodon. 2004;30(9):634-7.
138.     Hägewald S, Pischon N, Jawor P, Bernimoulin J-P, Zimmermann B. Effects of enamel matrix derivative on proliferation and differentiation of primary osteoblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:243-9.
139.     Mensi M, Salgarello S, Pinsi G, Piccioni M. Mycetoma of the maxillary sinus: Endodontic and microbiological correlations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:119-23.
140.     Halse A, Molven O. Increased width of the apical periodontal membrane space in endodontically treated teeth may represent favourable healing. Int Endod J. 2004;37:552-60.
141.     Martinez EF, Araújo VC. In vitro immunoexpression of extracellular matrix proteins in dental pulpal and gingival human fibroblasts. Int Endod J. 2004;37:749-55.
142.     Zhang X, Peng B. Immunolocalization of receptor activator of NF Kappa B Ligand in rat periapical lesions. J Endodon. 2005;31(8):574-7.
143.     Nakayama A, Ogiso B, Tanabe N, Takeichi O, Matsuzaka K, Inoue T. Behaviour of bone marrow osteoblast-like cells on mineral trioxide aggregate: morphology and expression of type I collagen and bone-related protein mRNAs. Int Endod J. 2005;38:203-10.
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