John C. Mitchell, Ph.D.
Assistant Professor, Department of Biomaterials & Biomechanics
Adjunct Assistant Professor, College of Dentistry, Ohio State University
Adjunct Assistant Professor, Dept of Consumer and Textile Sciences, Ohio State University

Phone: (503) 494-8223
Fax: (503) 494-8260
E-mail: mitchelj@ohsu.edu

MAJOR AREAS 

• Tissue engineering of bone defect filler materials 
• Development of synthetic bone graft augmentation materials, in particular, bioactive glasses and glass-ceramics for use in bone repair and regeneration
• Solution sol-gel synthesis of bioactive materials with defined physical/chemical properties
• Biomaterials for in-vivo drug delivery
• Electron microscopic digital imaging and morphometric analysis of bone-implant material interfaces
• Mechanical and chemical properties of static and dynamic bone tissues
• Primary cell culture for biomaterials testing

PREVIOUS POSITIONS 

The Ohio State University, Columbus, OH
    Jan 2000 – Sept 2000    Adjunct Assistant Professor: College of Dentistry, Department
                                       of Consumer and Textile Sciences, Department of Geological
                                       Sciences, and The Biomedical Engineering Center
    Jan 2000 – Sept 2000    Research Scientist: Department of Geological Sciences
    Mar 1997 – Jan 2000    Adjunct Instructor: Department of Geological Sciences
    Aug 1989 – Jan 2000    Senior Electron Microscopist: Dept. of Geological Science

DePuy Division, Boehringer Mannheim Corporation, Warsaw, IN
    Aug 1988 – Sept 1989   Laboratory Scientist

The Ohio State University, Columbus, OH
    Jun 1986 – Aug 1988    Research Associate: Department of Oral Biology
    Sept 1983 – July 1984   Research Assistant: Department of Oral Biology

 

EDUCATION 

• The Ohio State University, Columbus, OH
  Doctor of Philosophy, Tissue Engineering / Implant Biomaterials Science, 1999
       Dissertation:  A Bioactive Glass Material for the Delivery of Bone Morphogenetic
       Proteins: Synthesis by the Solution Sol-Gel Method, Physical and Chemical Analyses,
       and In-Vitro Testing
   
• The Ohio State University, Columbus, OH
  Bachelor of Science, Biological Sciences

 

RESEARCH INTERESTS 

Fundamental knowledge about the physical and chemical properties of a material is necessary in order to understand the interaction of the material with cells and tissues in a living system.  We are using electron microscopy, X-ray diffraction, FTIR, ICP, and DSC, as well as other techniques to characterize implant materials prior to investigating the material-cellular interactions in-vitro, using osteoblast-rich primary cell cultures.

We are also assessing the ability of various classes of bioactive materials to serve as tissue engineering scaffolds and drug delivery devices, by seeding them with cells and growing them in vitro and in-vivo.  We are thus creating three-dimensional constructs which may be used to provide rapid healing in surgically created bone defects, as well as off-the-shelf filler materials which greatly reduce the time necessary for full-strength restoration of bone function.
 

SELECTED RECENT PUBLICATIONS 

Wuenschmann, A., Marshall, B., Mitchell, J.C., and Weisbrode, S. Calcium Hydroxylapatite Deposition Disease in a Great Dane Puppy.  Veterinary Pathology 2000;37:346-349.

 

Papazoglou, E., Wu, Q., Brantley, W.A., Mitchell, J.C., and Meyrick, G. Comparison of Mechanical Properties for equiaxed fine-grained dendritic High-Palladium Alloys.  J Mater Sci: Mater Med 2000; 11: 601-608.

 

Tufekci, E., Brantley, W.A., Mitchell, J.C., Foreman, D.W., and Georgette, F.S. Crystallographic Characteristics of Plasma-Sprayed Calcium Phosphate Coatings on Ti-6AI-4V Dental Implants.  Int J Oral Maxillofac Implants 1999; 14:661-672. 

 

Kerber, S.J., Barr, T.L., Mann, G.P., Brantley, W.A., Papazoglou, E., and Mitchell, J.C.  The Complementary Nature of X-Ray Photoelectron Spectroscopy and Angular-Resolved X-Ray Diffraction: Analysis of Oxides on Dental Alloys.  J Mater Eng Perform 1998;7:334-342.

 

Tufekci, E., Brantley, W.A., Mitchell, J.C., and McGlumphy, E.A. Microstructures of Plasma Sprayed Hydroxyapatite-Coated TI-6AI-4V Dental Implants.  I. J of Oral Maxillofac Implants 1997;12-25-31.

 

Brantley, W.A., Tufekci, E., Mitchell, J.C., Foreman, D.W. and McGlumphy, E.A. Scanning Electron Microscopy Studies of Ceramic Layers and Interfacial Regions for Calcium Phosphate Coated Titanium Dental Implants.  Cell Mater 1995;5:73-82.

 

Vuddhakanok, S., Solt, C.W., Mitchell, J.C., Foreman, D.W. and Alger, F.A.  Histologic Evaluation of Periodontal Attachment Apparatus Following Insertion of a Biodegradable Copolymer Barrier in Humans.  J Perio., 1993;64:202-210.

 

Jakes, K.A., and Mitchell, J.C. The Recovery and Drying of Textiles from a Deep Ocean Historic Shipwreck.  J Amer. Inst. Conserv.,1992;31:343-353.

 

Foreman, D.W., Mitchell, J.C. and Baker, P.B.  Physical Chemical Evidence of Structural Weakness in Coronary Arterial Calcification.  Cardiovascular Research, 1989;23:64-69.

 

Mitchell, J.C., Brantley, W.A., Li, D., Daehn, G.S., Monaghan, P., and Papazoglou, E.  SEM Study of Fractured Fatigue Specimens for High-Palladium Alloys.  J Dent Res 2001;80 (Special Issue):52, Abstract # 134.

 

Rezvan, E., Mitchell, J.C., and Kupp, L.I.  Histomorphometric Analysis of Mineralized Freeze-dried Bone as a Grafting Material for Sinus Lift Procedures.  J Dent Res 2001;80 (Special Issue):222, Abstract # 1490.

 

Mitchell, J.C., Brantley, W.A., Tufekci, E., and Webb, C. S. X-ray Diffraction Analyses of Cross Sectioned Specimens of Titanium-Containing Orthodontic Wires.  J Dent Res 2000;79 (Special Issue):439, Abstract # 2368.

 

Tufekci, E., Mitchell, J.C., Olesik, J.W., Brantley, W.A., Papazoglou, E., and Monaghan, P. ICP/MS Measurement of Elemental Release from High-Palladium Dental Casting Alloys.  J. Dent Res 2000;79 (Special Issue):595, Abstract 4 3616.

 

Rezvan, E., Mitchell, J.C., Augustine, J., and Kupp, L.I. Growth Rate Analysis and Computerized Histomorphometric Evaluation of Onlay Bone Graft Procedures.  J Dent Res 2000;79 (Special Issue):511, Abstract # 2941.

 

Augustine, J., Rezvan, E., Mitchell, J.C., Carr, A.B. and Kupp, L.I. Histomorphometric and Growth Rate Analysis of the Sinus-Lift Procedure.  J Dent Res 2000;79 (Special Issue):511, Abstract # 2942.

 

Mitchell, J.C., Winnard, A., and Moursi, A.M. Proliferation of Osteoblasts on an Experimental Bioactive Glass Bone Implant Material.  J. Dent Res 1999;78 (Special Issue):536, Abstract # 3448.

 

Mitchell, J.C., Murdock, G.P., Johanni, E.J., and Carr, A.B. Histomorphometric Analysis of Bone Implant Interfaces Using an Automated Image Analysis System.  J Dent Res. 1998;77 (Special Issue):172, Abstract # 533.

 

Murdock, G.P., Mitchell, J.C., and Carr, A.B. Automated Measuring of Mineralized Bone Fraction around Endosseous Implants.  J Dent Res. 1996;75 (Special Issue):409, Abstract # 3130.

 

Mitchell, J.C., Tufekci, E., and Brantley, W.A. SEM/EDS Studies of Interdiffusion in Calcium Phosphate-Coated Implants.  J Dent Res. 1995;74 (Special Issue): 111, Abstract # 798.