The Skach laboratory is interested in recruiting motivated postdoctoral candidates with a strong interest in membrane protein biogenesis, protein translocation, membrane integration and/or ER-associated degradation. Currently there is a postdoctoral position open for the following project.
Membrane Biology/Biophysics. A position is available in the Department of Biochemistry & Molecular Biology to examine mechanisms of membrane protein folding and biogenesis. Projects will use cell free expression to incorporate fluorescent probes into nascent polypeptides using charged tRNA molecules. In vitro synthesized molecules will be characterized by fluorescence quenching and FRET to define how the Sec61 translocon facilitates translocation, membrane integration and early folding events of polytopic membrane proteins. Wild type proteins will be used as models to identify specific biogenesis events that are disrupted by disease-related mutations. PhD and/or MD is required, along with a strong background in biophysics/fluorescence spectroscopy, cell biology, biochemistry, and molecular biology. Salary commensurate with experience. Please submit letter of interest, curriculum vitae and names of three references to: Dr. William Skach, Department of Biochemistry & Molecular Biology. OHSU, L-224. Portland, Oregon, 97239. Fax: 503-494-7368, Email: firstname.lastname@example.org