IRB #

STUDY00017083

Title

Zoster Eye Disease Study (ZEDS): A multi-center, randomized, double-masked, placebo-controlled study of valacyclovir in immunocompetent subjects with a history of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) within the year prior to enrollment.

Principal Investigator

John Clements

Study Purpose

This study is looking to see if treatment with 12 months of daily study drug reduces the development of certain types of new or worsening eye disease; specifically, infection on the surface of the front of the eye (cornea), inflammation of the cornea, or inflammation inside the front of the eye (referred to as dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and iritis). We also hope to find out if this treatment reduces postherpetic neuralgia, the condition of ongoing pain after the shingles infection goes away. In addition, we want to find out if the effects of the study drug last during the six months after treatment is finished.

Medical Condition(s)

shingles of the eye

Eligibility Criteria

must have shingles of the eye

Age Range

18 - 100

Healthy Volunteers Needed

No

Duration of Participation

18 months

Minors Included

No

Contact

Tracy Giles
503-494-0482
gilest@ohsu.edu

Sponsor

Recruitment End

06/30/2018

Compensation Provided

No


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