Physical Activity and Obesity: The Role of Nitric Oxide and Eicosanoids in Regulating Capillary Perfusion and Vascular Insulin Resistance

Principal Investigator

Scott Chadderdon

Study Purpose

The study aims to see if regular exercise in overweight and pre-diabetic adults lead to reduced symptoms and a reduced risk of developing diabetes.

Medical Condition(s)

The study explores interactions between obesity, diabetes, and insulin resistance.

Eligibility Criteria

You must be:
- Between 30 and 60 years of age
- Diagnosed as obese or overweight (BMI between 28 and 45)
- Experiencing early signs of diabetes also known as "pre-diabetes" or insulin reistance or diagnosed with diabetes within 2 years with HbA1c of 5.7-6.7.
- Not engaged in an exercise program totaling more than 3 hours of physical activity per week
-Not be on insulin regulating drugs other than Metformin
-Not be taking any ACE inhibitors

You should not have:
- Stage 3 Kidney Disease
- Coronary Artery Disease
- Congestive Heart Failure
- Degenerative joint disease
- Peripheral vascular disease
- Any muscle or joint condition that would impair your ability to exercise
- A known allergy to ultrasound contrast dye

Age Range

30 - 60

Healthy Volunteers Needed


Duration of Participation

The whole study will take subjects about four months to complete. Study subjects should be prepared to commit to being selected for the exercise group that requires exercising for one hour three times a week.

Minors Included



Kate Haas - or 503-494-4786


Oregon Clinical and Translational Research Institute

Recruitment End


Compensation Provided



For completing the entire study, subjects will receive a Nike Fuel Band activity monitor. You must complete the entire study, including baseline and follow up testing, to receive the activity monitor.

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