Neural Mechanisms of Cognitive Inhibition in Youth with and without a Trauma History

Principal Investigator

Kristen Mackiewicz Seghete

Study Purpose

The goal of this project is to examine how brain activity changes in adolescents. Researchers are examining stress, life experiences, and brain and behavior changes in youth age 13-17. We will use a series of scanner activities, questionnaires, and behavioral tasks that utilize brain regions that are developing during this age range. We will also examine how various clinical and psychosocial variables impact brain activation. In the interest of supporting future studies and the training goals of the grant we will also be recruiting parents with a trauma history to explore intergenerational transmission of trauma.

Medical Condition(s)

No medical conditions are being studied.

Eligibility Criteria

Eligible participants will be between the ages of 13 and17 years old, right handed, with no braces or permanent retainers. . A subset of up to 20 parents (one parent per youth) will be invited to participate in an additional parent-only study session. Parents participating in the additional parent-only session will be recruited after they have completed the in-person screening session for the youth. Parents must endorse a personal history of childhood maltreatment on questionnaires completed during the in-person screening.

Age Range

13 - 65

Healthy Volunteers Needed


Duration of Participation

The participant and a legal guardian will complete initial phone interviews to determine initial eligibility. If the youth is eligible, the youth and at least one legal guardian will come in for more detailed interview sessions lasting 60-90 minutes. Eligible participants will be invited for a puzzles and games session (3 hours) and a scanning session (approximately 2 hours). Sessions may be completed in two or three visits at participant’s convenience. Study participation will be 6-7 hours in total. Participant may elect to be enrolled in follow up interviews one at 6 months and 1 year after the initial study visit. Follow up interviews (10-30 minutes) will be conducted in person at OHSU with participants enrolled through CARES and over the phone with participants enrolled through the community. Parents who participate in the parent-only session will be informed that participation in the study will take approximately 3 hours over one session.

Minors Included



Dr. Kristen Mackiewicz Seghete’s Lab: 503-494-4476


National Institutes of Health and Medical Research Foundation of Oregon

Recruitment End


Compensation Provided



Youth participants and their legal guardians will receive $20 each for completing the detailed interview session, regardless of eligibility outcome. Youth participants who complete the puzzles and games and scanning session will receive $100. If all sessions are not completed, youth will receive $15.00 an hour. Parents of youth who complete the puzzles and games session and scanning session will receive $30. Youth will receive $35 for 6 month follow up and $50 for 1 year follow up. Parents who complete the additional parent-only study session will receive $100; this amount will be prorated at $15 per hour for partial completion.

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