The Parkinson's Progression Markers Initiative (PPMI)
The purpose of this research study is to collect clinical information, samples of blood, urine, spinal fluid, and brain images from 1) people with Parkinson Disease (PD), 2) people who may be at risk to develop PD, and 3) from healthy people without PD.
The information collected in this study will be used to help develop biomarkers for PD. Biomarkers are measures that may help us to understand how PD changes over time and may help us test drugs to treat the disease in the future.
1) Parkinson disease 2) Hyposmia (decreased sense of smell) 3) No neurological disease
This study is currently recruiting 1) healthy volunteers 60 years or older who are willing to be screened for a decreased sense of smell and 2) people who know from prior genetic testing that they carry a "risk" gene for PD called LRRK2.
The study has completed recruitment of people with Parkinson disease.
30 - 80
Healthy Volunteers Needed
Duration of Participation
For subjects found to have decreased sense of smell on screening and choosing to participate for the full study, duration of participation will be 3 years.
The Michael J. Fox Foundation for Parkinson's Research
There is no reimbursement for the screening assessment for decreased sense of smell, which is done by mail. Subjects subsequently participating in the full study will be paid $50 for completing each of the following visits: the Screening visit, the 3 month, 9 month, 18 month, and 30 month visit. Subject will be paid $200 for completing each of the following visits: the Baseline visit, the 6 month, 12 month, 24 month, and 36 month visit. If the subject chooses to leave the study early, s/he will only be compensated for the visits completed.