IRB #

IRB00006459

Title

The Parkinson's Progression Markers Initiative (PPMI)

Principal Investigator

Penelope Hogarth

Study Purpose

The purpose of this research study is to collect clinical information, samples of blood, urine, spinal fluid, and brain images from 1) people with Parkinson Disease (PD) 2) people who may be at risk to develop PD, and 3) healthy controls

The information collected in this study will be used to help develop biomarkers for PD. Biomarkers are measures that may help us to understand how PD changes over time and may help us test drugs to treat the disease in the future.

Medical Condition(s)

1) Parkinson disease 2) Have a positive genetic mutation in the LRRK2, SNCA or GBA gene 3) Healthy controls

Eligibility Criteria

This study is currently recruiting 1) people who know from prior genetic testing that they carry a "risk" gene for PD called LRRK2, GBA, or SNCA. 2) Healthy people with a family history of PD of Ashkenazi Jewish or Italian heritage 3) Healthy people with a family history of the LRRK2, GBA, or SNCA gene mutation. 4) People with Parkinson's disease of Ashkenazi Jewish heritage.

The study has completed recruitment of healthy controls without the family history and ethnicity described above. The study has also completed recruitment of hyposmic (prodromal) subjects. Subjects in these groups are still being followed.


Age Range

18 - 80

Healthy Volunteers Needed

No

Duration of Participation

For subjects found to carry a LRRK2, GBA or SNCA mutation who choose to participate in the full study, duration of participation will be up to 5 years.

Minors Included

No

Contact

Research Coordinator
503-494-1382

Sponsor

The Michael J. Fox Foundation for Parkinson's Research

Recruitment End

06/01/2017

Compensation Provided

Yes

Compensation

There is no reimbursement (or cost to the participant) for the genetic testing pre-screening portion of the study. Subjects subsequently participating in the full study will be paid $50 for completing each of the following visits: the Screening visit, the 3 month, 9 month, 18 month, 30 month and 54 month visit. Subject will be paid $200 for completing each of the following visits: the Baseline visit, the 6 month, 12 month, 24 month, 36 month, 48 month and 60 month visit. If the subject chooses to leave the study early, s/he will only be compensated for the visits completed.


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