Histocompatible human pluripotent cells
The purpose of this study is to generate important new insights concerning the feasibility and efficiency of developing patient matched stem cells using novel experimental approaches. In addition we intend to study properties of such stem cells and their utility as a source of cells and tissues for regenerative medicine
Mitochondrial DNA mutations, Parkinson's disease, Diabetes, motor neuron disease
Women undergoing infertility treatments at OHSU IVF clinic and willing to donate their abnormal eggs and/or embryos created that cannot be used for infertility treatment and are routinely discarded. In addition, patients who choose to donate their healthy eggs and/or embryos for research can also participate in this study. Egg donors willing to donate their eggs will be also recruited. The age range of potential subjects include women from 21 to 35 years old.
Patients between the ages of 18 and 75 with mitochondrial DNA disease, type I diabetes, motor neuron disease (amyotrophic lateral sclerosis) or Parkinson's disease will be recruited to donate their skin samples for this study.
0 - 75
Healthy Volunteers Needed
Duration of Participation
OHSU Women's Health Research Unit
This study is currently supported by several non federal funds. These include:
1. Funds for Research, Development @ Administration (RDA) from the office of the vice President of OSHU for Research
2. Office of Technology Research Collaborations pursued funds and contract from a Venture Capitalist
Grant applications to private foundations (such as Keck foundation, March of Dimes, United Mitochondrial Disease Foundation) and pursuit of private donations is anticipated to provide funds in the future.
There will be no compensation for patients undergoing IVF treatment who is willing to donate their excess eggs or embryos for this study.
However, we will compensate healthy egg donors willing to donate their eggs for research. Financial compensation for donation of oocytes for research is ethically justified. Compensation will be for the time, effort, discomfort and inconvenience associated with the oocyte donation process and not for the oocytes themselves.Payment amounts will not exceed amounts considered appropriate for oocyte donation for fertility purposes ( $5,000).
Qualified skin donor participants will be reimbursed $50 for travel and other expenses incurred.