OHSU

Homologous recombination at OHSU

Definition
Experimental genetic modification that uses homologous recombination to change an endogenous gene. The method can be used to delete a gene, remove exons, add a gene, and introduce point mutations.
Synonyms
Targeted homologous recombination, Genetic engineering, Genome manipulation
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Transgenic Mouse Model Shared Resource

Department of Comparative Medicine, Oregon Health & Science University, Contact: Fedorov, Lev, Ph.D.

  • ES cell gene targeting