OHSU

Fluorescent in situ hybridization at OHSU

Definition
An in situ hybridization technique that is used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe is bound to the chromosomes.
Synonyms
FISH
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Clinical Cytogenetics Laboratory

Department of Molecular & Medical Genetics, Oregon Health & Science University, Contact: Olson, Susan B., Ph.D.

  • Abortus, stillbirth, and neonatal death specimen chromosomal analysis
  • DiGeorge/velocardiofacial syndrome screening
  • Fluorescent in-situ hybridization (FISH)
  • HER2 testing by FISH
  • Kallman Syndrome (X-linked) testing
  • Miller-Dieker lissencephaly syndrome testing
  • Prader-Willi diagnostic testing
  • Williams syndrome screening