Assistant Professor
phone: (503) 494-3990
fax: (503) 494-4816
e-mail: marshaly@ohsu.edu
Education
BS (1985) Cornell University
ScD (1996) Harvard University, School of Public Health
Dr. Marshall has substantial experience with the design and conduct
of cohort studies. As a doctoral student and research fellow, she
conducted research in the Nurses Health Study cohorts at the Harvard
School of Public Health. Currently, she is a co-investigator with
the Osteoporotic Fractures in Men (MrOS) study. From 1998-2001, she
developed public health surveillance programs for diabetes and asthma
while working for the State of Oregon. She has strong training in
quantitative epidemiologic and statistical methods, and substantial
knowledge in cancer, reproductive, and osteoporosis epidemiology.
My primary role within the department is to contribute to the development
of high quality curriculum pertaining to epidemiologic methods,
to provide thoughtful and thorough instruction in the epidemiology
courses, and to share my knowledge of epidemiologic and statistical
methods with students and my colleagues. With others, I share a
vision for a Department that has strong internal and external ties
with other professionals in our community, and strive in my own
way to create and maintain those connections through networking
and collaboration.
Since joining the faculty at OHSU, I have made a transition to epidemiologic
research on metabolic bone disease. My research program that focuses
broadly on the etiologic association of body composition with osteoporotic
fracture risk among older men. The rationale for this line of inquiry
ensues from observations that adults lose both skeletal muscle mass
and bone mass with age. Body composition likely influences bone
formation and resorption through mechanical and hormonal pathways.
Understanding the role of age-related change in body composition
and its influence on bone loss will improve our understanding of
fracture etiology.
My goals over the next 3-5 years are to:
· describe the natural history of age-related changes in
body composition, with particular emphasis on skeletal muscle mass
and density;
· identify the aspects of body composition that are determinants
of bone material and geometric properties, including trabecular
and cortical bone mineral density, cross-sectional area, and section
modulus;
· quantify the interactions of body composition and bone
material and geometric properties with risk of fracture.
To conduct this research, I collaborate with numerous
investigators and am using data from the MrOS study, a prospective
cohort of 5,995 community dwelling US men ages 65 and older. A unique
aspect of the MrOS cohort is the inclusion of quantitative computed
tomography (QCT), from which direct measures of bone, adipose tissue,
and skeletal muscle can be made.
Recent Publications
(click below for a full list of publications)
Orwoll E, Lambert LC, Marshall LM, Blank J, Barrett-Connor E, Cauley J, Ensrud K, Cummings SR. Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med 2006:166:2124-2131.
Orwoll E, Lambert LC, Marshall LM, Phipps K, Blank J, Barrett-Connor E, Cauley J, Ensrud K, Cummings S. Testosterone and estradiol among older men. J Clin Endocrinol Metab 2006;91:1336-1344.
Marshall LM, Lang TF, Lambert LC, Zmuda JM, Ensrud KE, Orwoll ES. Dimensions and volumetric bone density of the proximal femur and their relation to age among older US men. J Bone Miner Res 2006;21:1197-1206.
Marshall LM, Howard R, Sullivan A, Ngo D, Woodward J, Kohn M. Public
health surveillance approaches in Oregon’s Medicaid population.
J Public Health Manag Pract 2002;8:63-69.
Howard RN, Marshall LM, Mohr-Peterson J, Kohn MA.
Tracking Oregon Medicaid patients’ enrollment and health utilization
patterns. J Public Health Manag Pract 2002; 8:70-76.
Coronado GD, Marshall LM, Schwartz SM. Complications
in pregnancy, labor, and delivery with uterine leiomyomas: a population-based
study. Obstet Gynecol 2000;95:764-769.
Marshall
publications
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