Photo of Xiaolu (Lulu) A. Cambronne, Ph.D.

Xiaolu (Lulu) A. Cambronne Ph.D.

  • (503) 494-7632

    Portland Campus

    • Research Assistant Professor Vollum Institute
    • Cell, Developmental and Cancer Biology School of Medicine

Lulu Cambronne, Ph.D. is a Research Assistant Professor in the Vollum Institute and Oregon Health & Science University. Dr. Cambronne has a longstanding interest in the molecular mechanisms that underlie physiology and disease. A theme throughout her work includes the development of new molecular tools to address previously unattainable questions. The current research focus of the Cambronne group is to understand how changes in free nicotinamide adenine dinucleotide (NAD+) levels contribute to the progression and onset of age-related diseases. Under her direction, a collaborative team composed of members from the Goodman and Cohen labs developed a genetically-encoded fluorescent biosensor to monitor subcellular free NAD+ regulation in cells.

Dr. Cambronne has been honored both at the pre-doctoral and post-doctoral levels with individual Kirschstein National Service Research Awards from the National Institutes of Health, Albert J Ryan and Samuel Lunenfeld Fellowships, and named the 2013 OHSU New Inventor of the year for her development and commercialization of the RISC-trap assay to empirically identify targets for specific microRNAs in cells. 

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Areas of interest

  • Non-redox roles for metabolites
  • NAD, nicotinamide adenine dinucleotide
  • Fluorescent biosensors
  • Biochemistry, cell biology, molecular biology
  • Age-related pathologies

Education

  • B.S., University of Toronto 2003
  • Ph.D., Harvard University 2009

Honors and awards

  • University of Toronto Scholar Award (1999)
  • Howard Ferguson Scholarship, University College, University of Toronto (1999-2002)
  • Golden Key International Honor Society (2001)
  • Samuel Lunenfeld Fellowship, Hospital for Sick Children, Toronto, ON (2001)
  • Harvard Medical School. Dept of Pathology travel fellowship (2005)
  • Keystone Symposia Travel Scholarship, Big Sky, MT (2007)
  • Albert J. Ryan Fellow (2006-2009)
  • Individual Predoctoral National Research Service Award, F31 NINDS NIH (2006-2009)
  • Postdoctoral training fellowship, T32 NIH (2009-2010)
  • Individual Postdoctoral National Research Service Award, F32 NINDS NIH (2011-2013)
  • OHSU New Inventor of the Year (2013)
  • NIH Director's New Innovator Award (2017)

Publications

  • Cambronne XA, Stewart ML, Kim D, Jones-Brunette AM, Morgan RK, Farrens DL, Cohen MS, Goodman RH. (2016) Biosensor reveals multiple sources for mitochondrial NAD+. Science 352:1474-7.

  • Cambronne XA, Shen R, Auer PL, Goodman RH. (2012) Capturing microRNA targets using an RNA-induced solencing complex (RISC)-trap approach. PNAS 109(50):20473-8.

  • Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, Mandel G, Goodman RH. (2010) microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. PNAS 107(47):20382-7.

  • Ang XL, Seeburg DP, Sheng M, Harper JW. (2008) Regulation of Postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFβ-TRCP ubiquitin ligase in hippocampal neurons. J. Biol. Chem. 283:29424-32.

  • Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. (2008) SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452:370-4.

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