Photo of Xiangshu Xiao, Ph.D.

Xiangshu Xiao Ph.D.

Beijing Medical University, Beijing - B.S., 1994-98

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai M.S., 1998-2001

Purdue University, West Lafayette, IN - Ph.D., 2001-2005

University of Texas Southwestern Medical Center, Dallas, TX - Postodctoral, 200-2007

Oregon Health Science University, Portland, OR - Assistant Professor, 2007-2014

Oregon Health Science University, Portland, OR - Associate Professor, 2014-present

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Education

  • M.S., Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai China 2001
  • B.S., Beijing Medical University, Beijing China 1998
  • Ph.D., Purdue University, West Lafayette Indiana 2005

Memberships and associations

  • American Chemical Society,

Publications

  • "Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription." Bioorganic and Medicinal Chemistry Letters  In: , 03.11.2016.
  • "Systemic Inhibition of CREB is Well-tolerated in vivo." Scientific Reports  In: , Vol. 6, 34513, 03.10.2016.
  • "Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid." Prostaglandins and Other Lipid Mediators In: , 28.04.2016.
  • "Varicellazoster virus activates CREB, and inhibition of the pCREB-p300/CBP interaction inhibits viral replication in vitro and skin pathogenesis in vivo." Journal of Virology  In: , Vol. 90, No. 19, 2016, p. 8686-8697.
  • "Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity." Journal of Medicinal Chemistry  In: , Vol. 58, No. 12, 25.06.2015, p. 5075-5087.
  • "The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development." Nature Cell Biology  In: , Vol. 17, No. 5, 05.05.2015, p. 665-677.
  • "The chemistry and pharmacology of privileged pyrroloquinazolines." MedChemComm  In: , Vol. 6, No. 4, 01.04.2015, p. 510-520.
  • "Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant." Synthetic Communications  In: , Vol. 45, No. 1, 02.01.2015, p. 105-110.
  • "Novel type of prodrug activation through a long-range O,N-acyl transfer : A case of water-soluble CREB inhibitor." ACS Medicinal Chemistry Letters  In: , Vol. 5, No. 10, 09.10.2014, p. 1104-1109.
  • "Erratum : Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (MedChemComm (2013) (4) DOI: 10.1039/C3MD00134B)." MedChemComm  In: , Vol. 5, No. 8, 2014, p. 1254.
  • "Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription." Bioorganic and Medicinal Chemistry Letters  In: , Vol. 23, No. 19, 01.10.2013, p. 5371-5375.
  • "Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition." Letters in Organic Chemistry  In: , Vol. 10, No. 5, 06.2013, p. 380-384.
  • "Soluble epoxide hydrolase dimerization is required for hydrolase activity." Journal of Biological Chemistry In: , Vol. 288, No. 11, 15.03.2013, p. 7697-7703.
  • "Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine." MedChemComm  In: , Vol. 4, No. 9, 2013, p. 1275-1282.
  • "Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription." Bioorganic and Medicinal Chemistry  In: , Vol. 20, No. 23, 01.12.2012, p. 6811-6820.
  • "Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcription." Journal of Medicinal Chemistry  In: , Vol. 55, No. 8, 26.04.2012, p. 4020-4024.
  • "Targeting CREB for cancer therapy : Friend or foe." Current Cancer Drug Targets In: , Vol. 10, No. 4, 2010, p. 384-391.
  • "Discovery of a small-molecule inhibitor of the KIX-KID interaction." ChemBioChem  In: , Vol. 10, No. 17, 23.11.2009, p. 2721-2724.
  • "Rapid identification of improved protein ligands using peptoid microarrays." Bioorganic and Medicinal Chemistry Letters  In: , Vol. 19, No. 14, 15.07.2009, p. 3866-3869.
  • "Design and synthesis of a cell-permeable synthetic transcription factor mimic." Journal of Combinatorial Chemistry  In: , Vol. 9, No. 4, 07.2007, p. 592-600.
  • "A cell-permeable synthetic transcription factor mimic." Angewandte Chemie - International Edition  In: , Vol. 46, No. 16, 2007, p. 2865-2868.
  • "A general system for evaluating the efficiency of chromophore-assisted light inactivation (CALI) of proteins reveals Ru(ii) tris-bipyridyl as an unusually efficient "warhead"." Molecular BioSystems  In: , Vol. 4, No. 1, 2007, p. 59-65.
  • "On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride." Tetrahedron  In: , Vol. 62, No. 41, 09.10.2006, p. 9705-9712.
  • "Total synthesis and biological evaluation of 22-hydroxyacuminatine." Journal of Medicinal Chemistry  In: , Vol. 49, No. 4, 23.02.2006, p. 1408-1412.
  • "Isolation and characterization of coactivator-binding peptoids from a combinatorial library." Molecular BioSystems  In: , Vol. 2, No. 11, 2006, p. 568-579.
  • "A convergent and stereoselective synthesis of a seco-precursor of macrolactin A." Tetrahedron  In: , Vol. 61, No. 47, 21.11.2005, p. 11291-11298.
  • "Effect of E-ring modifications in camptothecin on topoisomerase I inhibition : A quantum mechanics treatment." Journal of Organic Chemistry  In: , Vol. 70, No. 23, 11.11.2005, p. 9584-9587.
  • "A facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl-1(2H)- isoquinolones to indeno[1,2-c]isoquinolines." Journal of Organic Chemistry  In: , Vol. 70, No. 16, 05.08.2005, p. 6496-6498.
  • "An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes." Journal of the American Chemical Society  In: , Vol. 127, No. 28, 20.07.2005, p. 9960-9961.
  • "Synthesis of a sec-precursor and analogues of macrolactin A." Chemistry Letters  In: , Vol. 34, No. 7, 05.07.2005, p. 906-907.

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