Photo of William Skach, M.D.

William Skach M.D.

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Dr. Skach received his BS in Biochemistry and Biophysics from Oregon State University in 1979 and his MD Degree from Harvard Medical School in 1983. He completed clinical training in Internal Medicine, Hematology and Oncology at University of California, San Francisco and then undertook postdoctoral studies with Vishwanath Lingappa, also at UCSF. He started his laboratory at the University of Pennsylvania and moved to OHSU in 1998.

Publications

  • "Patient-centered research priorities for pulmonary nontuberculous mycobacteria (NTM) infection an NTM research consortium workshop report." Annals of the American Thoracic Society In: , Vol. 13, No. 9, 01.09.2016, p. S379-S384.
  • "From CFTR biology toward combinatorial pharmacotherapy : Expanded classification of cystic fibrosis mutations." Molecular Biology of the Cell In: , Vol. 27, No. 3, 01.02.2016, p. 424-433.
  • "The ribosome-Sec61 translocon complex forms a cytosolically restricted environment for early polytopic membrane protein folding." Journal of Biological Chemistry In: , Vol. 290, No. 48, 27.11.2015, p. 28944-28952.
  • "Translational tuning optimizes nascent protein folding in cells." Science In: , Vol. 348, No. 6233, 24.04.2015, p. 444-448.
  • "Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events." Molecular Cell In: , Vol. 58, No. 2, 16.04.2015, p. 269-283.
  • "Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex." Nature Structural and Molecular Biology In: , Vol. 21, No. 3, 2014, p. 228-235.
  • "Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase." Journal of Biological Chemistry In: , Vol. 288, No. 43, 25.10.2013, p. 31069-31079.
  • "Two-step insertion at the SecY translocon." Nature Structural and Molecular Biology In: , Vol. 19, No. 10, 10.2012, p. 975-977.
  • "Thermal instability of Δf508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function : Protection by single suppressor mutations and inhibiting channel activity." Biochemistry In: , Vol. 51, No. 25, 26.06.2012, p. 5113-5124.
  • "Kinetic analysis of ribosome-bound fluorescent proteins reveals an early, stable, cotranslational folding intermediate." Journal of Biological Chemistry In: , Vol. 287, No. 4, 20.01.2012, p. 2568-2578.
  • "Epstein-barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP." Journal of Biological Chemistry  In: , Vol. 286, No. 48, 02.12.2011, p. 41402-41412.
  • "The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation." Journal of Virology  In: , Vol. 85, No. 17, 09.2011, p. 8766-8776.
  • "Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation." Molecular Biology of the Cell In: , Vol. 22, No. 16, 15.08.2011, p. 2797-2809.
  • "Protein folding and quality control in the endoplasmic reticulum : Recent lessons from yeast and mammalian cell systems." Current Opinion in Cell Biology In: , Vol. 23, No. 4, 08.2011, p. 464-475.
  • "Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex." Cell In: , Vol. 146, No. 1, 08.07.2011, p. 134-147.
  • "Ligand-Driven Vectorial Folding of Ribosome-Bound Human CFTR NBD1." Molecular Cell In: , Vol. 41, No. 6, 18.03.2011, p. 682-692.
  • "N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2 ." Journal of General Physiology  In: , Vol. 137, No. 3, 03.2011, p. 299-314.
  • "In vitro methods for CFTR biogenesis." Methods in molecular biology (Clifton, N.J.) In: , Vol. 741, 2011, p. 233-253.
  • "CFTR Folding Consortium : methods available for studies of CFTR folding and correction." Methods in molecular biology (Clifton, N.J.) In: , Vol. 742, 2011, p. 335-353.
  • "In vitro incorporation of nonnatural amino acids into protein using tRNACys-derived opal, ochre, and amber suppressor tRNAs." RNA In: , Vol. 16, No. 8, 08.2010, p. 1660-1672.
  • "Folding Biology of Cystic Fibrosis : A Consortium-Based Approach to Disease."   Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, 2010. p. 425-452.
  • "Role of Hsp90 in biogenesis of the β-cell ATP-sensitive potassium channel complex." Molecular Biology of the Cell  In: , Vol. 21, No. 12, 15.06.2010, p. 1945-1954.
  • "Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis." Nature Chemical Biology In: , Vol. 6, No. 1, 01.2010, p. 25-33.
  • "Cellular mechanisms of membrane protein folding." Nature Structural and Molecular Biology In: , Vol. 16, No. 6, 06.2009, p. 606-612.
  • "Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum sec61 translocon." Molecular Biology of the Cell In: , Vol. 20, No. 2, 15.01.2009, p. 685-698.
  • "Developing a cellular signature for CFTR modulators : A consortium approach." Pediatric Pulmonology In: , Vol. 44, No. SUPPL. 32, 2009, p. 152.
  • "Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking." Molecular Biology of the Cell In: , Vol. 19, No. 8, 08.2008, p. 3369-3378.
  • "Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome." Journal of Biological Chemistry In: , Vol. 283, No. 30, 25.07.2008, p. 20864-20873.
  • "The expanding role of the ER translocon in membrane protein folding." Journal of Cell Biology In: , Vol. 179, No. 7, 31.12.2007, p. 1333-1335.
  • "Pharmacological chaperoning : two 'hits' are better than one." Biochemical Journal In: , Vol. 406, No. 2, 01.09.2007.

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