Dr. Thuy Ngo is interested in taking interdisciplinary approaches to develop novel methods for identifying biomarkers of cancer, detecting and elucidating developmental pathway of cancer and other medical diseases and conditions. The clinical and biological systems under studying include circulating cell-free DNA, RNA, extracellular vesicles, microbiome, tumor cells, tumor associated cells and tumor microenvironment. Her main tools are quantitative imaging, next generation sequencing, bioinformatics and molecular and cellular biology.
Ngo received her Ph.D. in biophysics and computational biology from the University of Illinois at Urbana-Champaign under the guidance of Dr. Taekjip Ha and her postdoc with Dr. Stephen Quake at Stanford University.Read more
- Ph.D., University of Illinois, Urbana-Champaign, Champaign Illinois United States 2014
Thuy T. M. Ngo*, Mira N. Moufarrej*, Marie-Louise H. Rasmussen, Joan Camunas-Soler, Wenying Pan, et.al. Noninvasive blood tests for fetal development predicts gestational age and preterm delivery Science, Vol. 360, Issue 6393, pp. 1133-1136 (2018) Covered by major media: NYTimes, CNN, BBC, TIME Magazine, ABC News, The Guardian, US News, National Geographic, Daily Mail.
Björn Hellenkamp, Sonja Schmid, Olga Doroshenko, Oleg Opanasyuk, Ralf Kühnemuth et. al. Precision and accuracy of single-molecule FRET measurements – a worldwide benchmark study Nature Methods (2018), accepted, deposited the preprint to biorxiv at https://arxiv.org/abs/1710.03807
Mohammad Sajjad Ghaemi, Daniel B. DiGiulio, Kévin Contrepois, Benjamin Callahan, Thuy T. M. Ngo, et.al. Multiomics Modeling of the Immunome, Transcriptome, Microbiome, Proteome, and Metabolome Adaptations During Human Pregnancy Bioinformatics (2018), (https://doi.org/10.1093/bioinformatics/bty537)
Wenying Pan, Thuy T. M. Ngo, Joan Camunas-Soler, Chunxiao Song, Mark Alec Kowarsky, et. al. Simultaneously Monitoring Immune Response and Microbial Infections during Pregnancy through Plasma cfRNA Sequencing Clinical Chemistry 63:11 (2017). Featured on cover page.
Farhan Chowdhury, Isaac T. S. Li, Thuy T. M. Ngo, Ben J. Leslie, Byoung Choul Kim, et. al. Defining single molecular forces required for Notch activation using nano yoyo Nano Letters, 16 (6), pp 3892–3897, (2016)
Thuy T. M. Ngo, Jejoong Yoo, Qing Dai, Qiucen Zhang, Chuan He, et. al. Effects of Cytosine Modifications on DNA Flexibility and Nucleosome Mechanical Stability Nature Communications, 7, 10813 (2016)
Thuy T. M. Ngo, Qiucen Zhang, Ruobo Zhou, Jaya Yodh, Taekjip Ha. Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Flexibility Cell, 160 (6), 1135-1144 (2015). Featured in News and Views: Moevus and Greene, Cell, 160 (6), 1039-1040 (2015)
Thuy T. M. Ngo, Taekjip Ha. Nucleosomes Undergo Slow Spontaneous Gaping. Nucleic Acids Research, 43 (8), 3964-3971 (2015)
Christopher Maffeo, Thuy T. M. Ngo, Taekjip Ha, Aleksei Aksimentiev. A Coarse-grained Model of Unstructed Single-stranded DNA Derived from Atomistic Simulation and Single-molecule Experiment Journal of Chemical Theory and Computation, 10, 2891-2896 (2014).
R. Kramer Campen, Thuy T. M. Ngo, Maria Sovago, Jean-Marie Ruysschaert and Mischa Bonn. Molecular Restructuring of Water and Lipids upon the Interaction of DNA with Lipids Monolayers Journal of American Chemical Society, 132, 8037-8047 (2010).