Photo of Steven A. Shea, Ph.D.

Steven A. Shea Ph.D.

  • (503) 494-2517
    • Professor Oregon Institute of Occupational Health Sciences
    • Professor OHSU-PSU School of Public Health

The goal of Dr. Shea’s research is to understand the biological basis behind changes in disease severity across the day and night, and to understand the physiological and adverse health effects of shift work. For instance, Dr. Shea is determining whether cardiovascular changes across the day and night are caused by the body clock (the endogenous circadian pacemaker) or attributable to behaviors that occur on a regular daily basis, including the sleep/wake cycle. Understanding the biological basis of these physiological and pathophysiological changes across the day and night may provide an insight into the underlying cause of the disease and could lead to better therapy (e.g. appropriately timed medication to target specific phases of the body clock or to coincide with specific behaviors that cause vulnerability, such as exercise), and countermeasures aimed at reducing the adverse health effects of shift work.

Education

  • Ph.D., University of London United Kingdom 1989
  • B.Sc., Loughborough University United Kingdom 1982
  • Certifications:

    • Certificate of Completion, Leadership Program, Brigham & Women’s Hospital, Harvard Business School, Boston, MA, 2010

Memberships and associations

  • Sleep Research Society
  • American Academy of Sleep Medicine

Publications

  • "24-hour profile of serum sclerostin and its association with bone biomarkers in men." Osteoporosis International In: , 26.07.2017, p. 1-9.
  • "Progression of Dementia Assessed by Temporal Correlations of Physical Activity : Results from a 3.5-Year, Longitudinal Randomized Controlled Trial." Scientific Reports  In: , Vol. 6, 27742, 13.06.2016.
  • "Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology." Diabetes  In: , Vol. 65, No. 6, 01.06.2016, p. 1741-1751.
  • "Circadian gene variants influence sleep and the sleep electroencephalogram in humans." Chronobiology International  In: , Vol. 33, No. 5, 27.05.2016, p. 561-573.
  • "ATS core curriculum 2016 : Part I. adult sleep medicine." Annals of the American Thoracic Society  In: , Vol. 13, No. 4, 01.04.2016, p. 549-561.
  • "Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale." Laryngoscope In: , 2016.
  • "Are we underestimating the lifelong benefits of therapy for obstructive sleep apnea?" Nature and Science of Sleep In: , Vol. 8, 2016, p. 87-89.
  • "A growth spurt in pediatric sleep research." Nature and Science of Sleep In: , Vol. 8, 2016, p. 133-135.
  • "Brachial artery endothelial function is stable across the morning in young men." Cardiovascular Ultrasound In: , Vol. 13, No. 1, 36, 01.12.2015.
  • "The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea." Sleep In: , Vol. 38, No. 11, 01.11.2015, p. 1793-1801.
  • "Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans." Brain, Behavior, and Immunity In: , Vol. 47, 01.07.2015, p. 4-13.
  • "Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 112, No. 17, 28.04.2015, p. E2225-E2234.
  • "Obstructive sleep apnea and metabolic bone disease : Insights into the relationship between bone and sleep." Journal of Bone and Mineral Research In: , Vol. 30, No. 2, 01.02.2015, p. 199-211.
  • "Simulated shift work in rats perturbs multiscale regulation of locomotor activity." Journal of the Royal Society Interface  In: , Vol. 11, No. 96, 20140318, 06.07.2014.
  • "Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle." Blood In: , Vol. 123, No. 4, 23.01.2014, p. 590-593.
  • "The role of the circadian system in fractal neurophysiological control." Biological Reviews  In: , Vol. 88, No. 4, 11.2013, p. 873-894.
  • "Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia." Scientific Reports  In: , Vol. 3, 2229, 18.07.2013.
  • "The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors." Obesity In: , Vol. 21, No. 3, 03.2013, p. 421-423.
  • "Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments." Journal of Clinical Sleep Medicine In: , Vol. 9, No. 2, 2013, p. 109-116.
  • "Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers : A randomized controlled trial." Sleep In: , Vol. 35, No. 10, 01.10.2012, p. 1395-1402.
  • "Obesity and pharmacologic control of the body clock." New England Journal of Medicine In: , Vol. 367, No. 2, 12.07.2012, p. 175-178.
  • "Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption." Science Translational Medicine In: , Vol. 4, No. 129, 129ra43, 11.04.2012.
  • "Klf15 orchestrates circadian nitrogen homeostasis." Cell Metabolism In: , Vol. 15, No. 3, 07.03.2012, p. 311-323.
  • "Circadian rhythms govern cardiac repolarization and arrhythmogenesis." Nature In: , Vol. 483, No. 7387, 01.03.2012, p. 96-101.
  • "Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions." PLoS One  In: , Vol. 7, No. 11, e48927, 2012.
  • "Sleep disorders, health, and safety in police officers." JAMA - Journal of the American Medical Association In: , Vol. 306, No. 23, 21.12.2011, p. 2567-2578.
  • "Response to letter regarding article, endogenous circadian rhythm in vasovagal response to head-up tilt." Circulation  In: , Vol. 124, No. 13, 27.09.2011.
  • "The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors." PLoS One In: , Vol. 6, No. 9, e24549, 08.09.2011.
  • "Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening." Circulation Research  In: , Vol. 108, No. 8, 15.04.2011, p. 980-984.
  • "Endogenous circadian rhythm in vasovagal response to head-up tilt." Circulation In: , Vol. 123, No. 9, 08.03.2011, p. 961-970.

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