Dr. Wong received his Ph.D. from Stanford University School of Medicine in 1987 studying eukaryotic DNA replication. Upon completing his degree he performed post-doctoral research at Stanford University and later at Harvard Medical School, where he focused on human herpesvirus replication and pathogenesis. He came to the Oregon Regional Primate Research Center in 1991 as an Assistant Scientist in the Division of Pathobiology and Immunology, and is now a Senior Scientist and interim Division Chief. Dr. Wong’s primary appointment is in the Vaccine and Gene Therapy Institute, where he is a Senior Scientist and a Professor of Molecular Microbiology and Immunology in the OHSU School of Medicine.
Understanding how viruses cause disease is important to the development of effective antiviral therapies and potential vaccines.
The long-term goal of the Wong laboratory is to understand how viruses cause disease. This is important in developing effective antiviral therapies and potential vaccines. The Wong lab is currently investigating two types of viruses: orthopoxviruses, which induce disease similar to smallpox; and herpesviruses, which can induce severe disease in individuals. Some of these viruses are very specific for their natural hosts, a factor that complicates the ability to study the mechanisms of the human viruses in an animal model. An alternative approach is to utilize animal models that harbor viruses that are closely related to the human virus. One animal model that has proven to be invaluable in understanding the mechanisms of infectious disease and for vaccine development is the nonhuman primate.
By employing molecular, genetic and virological techniques, members of Dr. Wong’s laboratory examine how these nonhuman primate viruses infect and replicate in cell culture and eventually how they cause illnesses in vivo. They have shown that experimental inoculation of normal monkeys with orthopoxviruses causes disease that is virtually identical to smallpox and have identified novel viral proteins utilizing proteomic analysis that may facilitate disease. Additionally, experimental infection of immunocompromised monkeys with simian herpesviruses results in disease manifestations that closely resemble those observed in humans infected with the human immunodeficiency virus (HIV). Utilizing these techniques they are identifying the viral determinants that contribute to disease and are devising novel recombinant molecules to help prevent viral pathogenesis.Read more
Areas of interest
- HIV pathogenesis and vaccine development
- Ph.D., Stanford University School of Medicine, Stanford California United States 1987
Skalsky RL, Barr SA, Jeffery AJ, Blair T, Estep R, Wong SW. Japanese Macaque Rhadinovirus Encodes a Viral MicroRNA Mimic of the miR-17 Family. JVirol. 2016 Sep 29;90(20):9350-63. doi: 10.1128/JVI.01123-16. PMID: 27512057, PMCID: PMC5044857
Blair TC, Manoharan M, Rawlings-Rhea SD, Tagge I, Kohama SG,Hollister-Smith J, Ferguson B, Woltjer RL, Frederick MC, Pollaro J, Rooney WD,Sherman LS, Bourdette DN, Wong SW. Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. J Neuroimmunol. 2016 Feb15;291:1-10. doi: 10.1016/j.jneuroim.2015.11.026. PMID: 26857488, PMCID: PMC4748211
Morin G, Robinson BA, Rogers KS, Wong SW.;A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response. J Virol. 2015 Aug;89(15):7707-21.doi: 10.1128/JVI.01175-15. PMID: 25972548, PMCID: PMC4505633
- "Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis." Journal of Neuroimmunology In: , Vol. 291, 15.02.2016, p. 1-10.
- "Japanese macaque rhadinovirus encodes a viral microRNA mimic of the miR-17 family." Journal of Virology In: , Vol. 90, No. 20, 2016, p. 9350-9363.
- "BoHV-4-based vector single heterologous antigen delivery protects STAT1 mice from monkeypoxvirus lethal challenge." PLoS Neglected Tropical Diseases In: , Vol. 9, No. 6, e0003850, 18.06.2015.
- "A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques." Virology In: , Vol. 474, 01.01.2015, p. 186-198.
- "A rhesus rhadinovirus viral interferon (IFN) regulatory factor is virion associated and inhibits the early IFN antiviral response." Journal of Virology In: , Vol. 89, No. 15, 2015, p. 7707-7721.
- "The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection." Journal of Virology In: , Vol. 88, No. 18, 2014, p. 10635-10654.
- "T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence." PLoS Pathogens In: , Vol. 10, No. 5, e1004123, 2014.
- "Rhesus macaque rhadinovirus-associated disease." Current Opinion in Virology In: , Vol. 3, No. 3, 06.2013, p. 245-250.
- "Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 110, No. 8, 19.02.2013, p. 3059-3064.
- "Erratum : Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions (Journal of Proteome Research (2008) 7:3 (960-968) DOI: 10.1021/pr070432+)." Journal of Proteome Research In: , Vol. 12, No. 1, 04.01.2013, p. 546.
- "Genomic characterization of japanese macaque rhadinovirus, a novel herpesvirus isolated from a nonhuman primate with a spontaneous inflammatory demyelinating disease." Journal of Virology In: , Vol. 87, No. 1, 01.2013, p. 512-523.
- "Author's correction : Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection." Journal of Virology In: , Vol. 86, No. 8, 04.2012, p. 4721.
- "Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection." Journal of Virology In: , Vol. 86, No. 5, 03.2012, p. 2769-2779.
- "Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection." Journal of Virology In: , Vol. 86, No. 4, 02.2012, p. 2197-2211.
- "Nonhuman primate gamma-herpesviruses and their role in cancer." Current Cancer Research. Vol. 8 2012. p. 201-214 (Current Cancer Research; Vol. 8).
- "Japanese macaque encephalomyelitis : A spontaneous multiple sclerosis-like disease in a nonhuman primate." Annals of Neurology In: , Vol. 70, No. 3, 09.2011, p. 362-373.
- "Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection." Journal of Virology In: , Vol. 85, No. 18, 09.2011, p. 9527-9542.
- "Nonhuman primate models of human immunology." Antioxidants and Redox Signaling In: , Vol. 14, No. 2, 15.01.2011, p. 261-273.
- "Characterization of macaque pulmonary fluid proteome during monkeypox infection : Dynamics of host response." Molecular and Cellular Proteomics In: , Vol. 9, No. 12, 12.2010, p. 2760-2771.
- "Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques." Virology In: , Vol. 405, No. 2, 30.09.2010, p. 592-599.
- "Simian herpesviruses and their risk to humans." Vaccine In: , Vol. 28, No. SUPPL. 2, 26.05.2010.
- "Autoexcision of bacterial artificial chromosome facilitated by terminal repeat-mediated homologous recombination : A novel approach for generating traceless genetic mutants of herpesviruses." Journal of Virology In: , Vol. 84, No. 6, 03.2010, p. 2871-2880.
- "Immune response to the West Nile virus in aged non- human primates." PLoS One In: , Vol. 5, No. 12, e15514, 2010.
- "Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD)." Journal of Medical Primatology In: , Vol. 38, No. SUPPL. 1, 10.2009, p. 2-7.
- "Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)." Comparative Medicine In: , Vol. 59, No. 4, 08.2009, p. 383-390.
- "Mutations in the highly conserved SLQYLA motif of Vif in a simian-human immunodeficiency virus result in a less pathogenic virus and are associated with G-to-A mutations in the viral genome." Virology In: , Vol. 383, No. 2, 20.01.2009, p. 362-372.
- "Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP)." Journal of Biological Chemistry In: , Vol. 284, No. 1, 02.01.2009, p. 505-514.
- "Primate models for gammaherpesvirus-associated malignancies." DNA Tumor Viruses. Springer US, 2009. p. 703-733.
- "Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems." Journal of Biomolecular Techniques In: , Vol. 19, No. 5, 12.2008, p. 285-295.
- "Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma : animal model for KSHV-associated malignancies." Blood In: , Vol. 112, No. 10, 15.11.2008, p. 4227-4234.